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Cerebrospinal fluid...
Cerebrospinal fluid Alzheimer's disease biomarkers across the spectrum of lewy body diseases : Results from a large multicenter cohort
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- Van Steenoven, Inger (author)
- Amsterdam UMC - Vrije Universiteit Amsterdam
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- Aarsland, Dag (author)
- Karolinska Institutet
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- Weintraub, Daniel (author)
- University of Pennsylvania
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- Londos, Elisabet (author)
- Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups
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- Blanc, Frederic (author)
- University Hospital Of Strasbourg
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- Van Der Flier, Wiesje M. (author)
- Amsterdam UMC - Vrije Universiteit Amsterdam
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- Teunissen, Charlotte E. (author)
- Amsterdam UMC - Vrije Universiteit Amsterdam
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- Mollenhauer, Brit (author)
- University of Göttingen
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- Fladby, Tormod (author)
- Akershus University Hospital
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- Kramberger, Milica G. (author)
- University Medical Centre Ljubljana
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- Bonanni, Laura (author)
- University G.d'Annunzio of Chieti-Pescara
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- Lemstra, Afina W. (author)
- Amsterdam UMC - Vrije Universiteit Amsterdam
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Blanc, 'E (author)
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(creator_code:org_t)
- 2016
- 2016
- English 9 s.
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In: Journal of Alzheimer's Disease. - 1387-2877 .- 1875-8908. ; 54:1, s. 287-295
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Abstract
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- Background: Concomitant Alzheimer's disease (AD) pathology is observed in Lewy body diseases (LBD), but the clinical impact is unknown. Only a few biomarker studies in LBD exist and have included small cohorts from single centers. Objective: We aimed to evaluate the prevalence of abnormal cerebrospinal fluid (CSF) AD biomarkers across the spectrum of LBD in a large multicenter cohort and to assess whether an AD biomarker profile was associated with demographic and clinical differences in dementia with Lewy bodies (DLB). Methods:We included 375 DLB patients, 164 Parkinson's disease (PD) patients without dementia, and 55 PD patients with dementia (PDD) from 10 centers. CSF amyloid-beta42 (Aβ42), total tau (t-tau), and phosphorylated tau (p-tau) values were dichotomized as abnormal or normal according to locally available cut-off values. A CSF AD profile was defined as abnormal Aβ42 combined with abnormal t-tau and/or p-tau. Results: A substantial proportion of DLB patients had abnormal values for CSF Aβ42, t-tau, and p-tau, while abnormal values were uncommon in PD without dementia. Patients with PDD had values in between. A CSF AD profile was observed in 25% of DLB patients, compared with only 9% of PDD and 3% of PD without dementia.Within DLB, patients with a CSF AD profile were older, more often female, performed worse on the Mini-Mental State Examination, and had shorter disease duration compared with patients with normal CSF. Conclusion: A CSF AD profile is more common in DLB compared with PDD and PD, and is associated with more severe cognitive impairment in DLB.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Keyword
- Amyloid beta-protein (1-42)
- Biomarkers
- Cerebrospinal fluid
- Dementia with Lewy bodies
- Lewy body disease
- Tau protein
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Van Steenoven, I ...
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Aarsland, Dag
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Weintraub, Danie ...
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Londos, Elisabet
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Blanc, Frederic
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Van Der Flier, W ...
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show more...
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Teunissen, Charl ...
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Mollenhauer, Bri ...
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Fladby, Tormod
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Kramberger, Mili ...
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Bonanni, Laura
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Lemstra, Afina W ...
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Blanc, 'E
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
- Articles in the publication
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Journal of Alzhe ...
- By the university
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Lund University
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Karolinska Institutet