Search: onr:"swepub:oai:lup.lub.lu.se:cd696f35-4258-4cb4-a0e2-3f22310c85e5" >
Polymorphisms in me...
Polymorphisms in metabolic genes related to tobacco smoke and the risk of gastric cancer in the European prospective investigation into cancer and nutrition
- Article/chapterEnglish2006
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Numbers
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LIBRIS-ID:oai:lup.lub.lu.se:cd696f35-4258-4cb4-a0e2-3f22310c85e5
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https://lup.lub.lu.se/record/681916URI
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https://doi.org/10.1158/1055-9965.EPI-06-0072DOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:art swepub-publicationtype
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Subject category:ref swepub-contenttype
Notes
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Metabolizing enzymes, which often display genetic polymorphisms, are involved in the activation of compounds present in tobacco smoke that may be relevant to gastric carcinogenesis. We report the results of a study looking at the association between risk of gastric adenocarcinoma and polymorphisms in genes CYP1A1, CYP1A2, EPHX1, and GSTT1. A nested case-control study was carried out within the European Prospective Investigation into Cancer and Nutrition, developed in 10 European countries. The study includes 243 newly diagnosed cases of histologically confirmed gastric adenocarcinoma and 946 controls matched by center, age, sex, and date of blood collection. Genotypes were determined in nuclear DNA from WBCs. We found an increased risk of gastric cancer for homozygotes for C (histidine) variant in Y113H of EPHX1 (odds ratio, 1.91; 95% confidence interval, 1.19-3.07) compared with subjects with TC/TT. There was also a significant increased risk for smokers carrying at least one variant allele A in Ex7+129C > A (m4) of CYP1A1 and never smokers with null GSTT1 and allele A in the locus -3859G > A of CYP1A2. Most of these genes are involved in the activation and detoxification of polycyclic aromatic hydrocarbons, suggesting a potential role of these compounds in gastric carcinogenesis.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Sala, Nuria
(author)
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Pera, Guillem
(author)
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Capella, Gabriel
(author)
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Berenguer, Antonio
(author)
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Garcia, Nadia
(author)
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Palli, Domenico
(author)
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Boeing, Heiner
(author)
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Del Giudice, Giuseppe
(author)
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Saieva, Calogero
(author)
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Carneiro, Fatima
(author)
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Berrino, Franco
(author)
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Sacerdote, Carlotta
(author)
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Tumino, Rosario
(author)
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Panico, Salvatore
(author)
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Berglund, GöranLund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups(Swepub:lu)medf-gbe
(author)
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Simán, HenrikLund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups(Swepub:lu)mikr-hsi
(author)
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Stenling, Roger
(author)
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Hallmans, Goran
(author)
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Martinez, Carmen
(author)
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Bilbao, Roberto
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Barricarte, Aurelio
(author)
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Navarro, Carmen
(author)
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Quiros, Jose R.
(author)
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Allen, Naomi
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Key, Tim
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Bingham, Sheila
(author)
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Khaw, Kay-Tee
(author)
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Linseisen, Jakob
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Nagel, Gabriele
(author)
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Overvad, Kim
(author)
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Tjonneland, Anne
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Olsen, Anja
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Bueno-de-Mesquita, H. Bas
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Boshuizen, Hendriek C.
(author)
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Peeters, Petra H.
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Numans, Mattijs E.
(author)
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Clavel-Chapelon, Francoise
(author)
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Boutron-Ruault, Marie-Christine
(author)
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Trichopoulou, Antonia
(author)
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Lund, Eiliv
(author)
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Offerhaus, Johan
(author)
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Jenab, Mazda
(author)
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Ferrari, Pietro
(author)
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Norat, Teresa
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Riboli, Elio
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Gonzalez, Carlos A.
(author)
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Internmedicin - epidemiologiForskargrupper vid Lunds universitet
(creator_code:org_t)
Related titles
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In:Cancer Epidemiology Biomarkers & Prevention15:12, s. 2427-24341538-7755
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Agudo, Antonio
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Sala, Nuria
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Pera, Guillem
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Capella, Gabriel
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Berenguer, Anton ...
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Garcia, Nadia
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Palli, Domenico
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Boeing, Heiner
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Del Giudice, Giu ...
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Saieva, Calogero
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Carneiro, Fatima
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Berrino, Franco
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Sacerdote, Carlo ...
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Tumino, Rosario
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Panico, Salvator ...
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Berglund, Göran
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Simán, Henrik
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Stenling, Roger
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Hallmans, Goran
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Martinez, Carmen
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Bilbao, Roberto
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Barricarte, Aure ...
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Navarro, Carmen
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Quiros, Jose R.
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Allen, Naomi
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Key, Tim
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Bingham, Sheila
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Khaw, Kay-Tee
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Linseisen, Jakob
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Nagel, Gabriele
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Overvad, Kim
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Tjonneland, Anne
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Olsen, Anja
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Bueno-de-Mesquit ...
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Boshuizen, Hendr ...
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Peeters, Petra H ...
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Numans, Mattijs ...
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Clavel-Chapelon, ...
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Boutron-Ruault, ...
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Trichopoulou, An ...
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Lund, Eiliv
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Offerhaus, Johan
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Jenab, Mazda
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Ferrari, Pietro
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Norat, Teresa
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Riboli, Elio
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Gonzalez, Carlos ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Cancer and Oncol ...
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Cancer Epidemiol ...
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Lund University