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RUBIC (ReproUnion B...
RUBIC (ReproUnion Biobank and Infertility Cohort) : A binational clinical foundation to study risk factors, life course, and treatment of infertility and infertility-related morbidity
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- Priskorn, Lærke (author)
- Copenhagen University Hospital
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- Tøttenborg, Sandra Søgaard (author)
- Copenhagen University Hospital
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- Almstrup, Kristian (author)
- Copenhagen University Hospital
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- Andersson, Anna Maria (author)
- Copenhagen University Hospital
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- Axelsson, Jonatan (author)
- Skåne University Hospital
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- Bräuner, Elvira Vaclavik (author)
- Copenhagen University Hospital
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- Elenkov, Angel (author)
- Skåne University Hospital
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- Freiesleben, Nina la Cour (author)
- University of Copenhagen,Copenhagen University Hospital
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- Giwercman, Yvonne Lundberg (author)
- Lund University,Lunds universitet,Molekylärgenetisk reproduktionsmedicin, Malmö,Forskargrupper vid Lunds universitet,Molecular genetic reproductive medicine, Malmö,Lund University Research Groups
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- Grøndahl, Marie Louise (author)
- Gentofte Hospital
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- Hansen, Ann Holm (author)
- Copenhagen University Hospital
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- Hansen, Laura Smidt (author)
- Copenhagen University Hospital
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- Henic, Emir (author)
- Skåne University Hospital
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- Kitlinski, Margareta Laczna (author)
- Skåne University Hospital
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- Landersoe, Selma Kloeve (author)
- Copenhagen University Hospital
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- Lindh, Christian (author)
- Lund University,Lunds universitet,Avdelningen för arbets- och miljömedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Occupational and Environmental Medicine, Lund University,Department of Laboratory Medicine,Faculty of Medicine
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- Løkkegaard, Ellen Leth (author)
- University of Copenhagen,Copenhagen University Hospital
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- Malm, Johan (author)
- Lund University,Lunds universitet,Institutionen för translationell medicin,Medicinska fakulteten,Department of Translational Medicine,Faculty of Medicine
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- Olsen, Kristina Wendelboe (author)
- Copenhagen University Hospital
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- Petersen, Kajsa Uglevig (author)
- Copenhagen University Hospital
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- Schmidt, Lone (author)
- University of Copenhagen
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- Stormlund, Sacha (author)
- Copenhagen University Hospital
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- Svendsen, Pernille Fog (author)
- Gentofte Hospital
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- Vassard, Ditte (author)
- University of Copenhagen
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- Wang, Nathalie Friis (author)
- Copenhagen University Hospital
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- Zedeler, Anne (author)
- Copenhagen University Hospital
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- Bhasin, Shalender (author)
- Harvard Medical School
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- Chavarro, Jorge (author)
- Harvard University
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- Eisenberg, Michael L. (author)
- Stanford University
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- Hauser, Russ (author)
- Harvard University
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- Huhtaniemi, Ilpo (author)
- Imperial College London
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- Krawetz, Stephen A. (author)
- Wayne State University
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- Marko-Varga, György (author)
- Lund University,Lunds universitet,Avdelningen för Biomedicinsk teknik,Institutionen för biomedicinsk teknik,Institutioner vid LTH,Lunds Tekniska Högskola,Department of Biomedical Engineering,Departments at LTH,Faculty of Engineering, LTH
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- Salonia, Andrea (author)
- Vita-Salute San Raffaele University,San Raffaele Hospital
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- Toppari, Jorma (author)
- University of Turku,Turku University Hospital
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- Juul, Anders (author)
- University of Copenhagen,Copenhagen University Hospital
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- Jørgensen, Niels (author)
- Copenhagen University Hospital
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- Nielsen, Henriette Svarre (author)
- Copenhagen University Hospital,University of Copenhagen
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- Pinborg, Anja (author)
- Copenhagen University Hospital,University of Copenhagen
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- Rylander, Lars (author)
- Lund University,Lunds universitet,Avdelningen för arbets- och miljömedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Miljöepidemiologi,Forskargrupper vid Lunds universitet,Division of Occupational and Environmental Medicine, Lund University,Department of Laboratory Medicine,Faculty of Medicine,Environmental Epidemiology,Lund University Research Groups
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- Giwercman, Aleksander (author)
- Lund University,Lunds universitet,Reproduktionsmedicin, Malmö,Forskargrupper vid Lunds universitet,Reproductive medicine, Malmö,Lund University Research Groups,Skåne University Hospital
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(creator_code:org_t)
- 2021-06-18
- 2021
- English.
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In: Andrology. - : Wiley. - 2047-2919 .- 2047-2927. ; 9:6, s. 1828-1842
- Related links:
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http://dx.doi.org/10... (free)
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https://onlinelibrar...
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Abstract
Subject headings
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- Background: Infertility affects 15%–25% of all couples during their reproductive life span. It is a significant societal and public health problem with potential psychological, social, and economic consequences. Furthermore, infertility has been linked to adverse long-term health outcomes. Despite the advanced diagnostic and therapeutic techniques available, approximately 30% of infertile couples do not obtain a live birth after fertility treatment. For these couples, there are no further options to increase their chances of a successful pregnancy and live birth. Objectives: Three overall questions will be studied: (1) What are the risk factors and natural life courses of infertility, early embryonic loss, and adverse pregnancy outcomes? (2) Can we develop new diagnostic and prognostic biomarkers for fecundity and treatment success? And (3) what are the health characteristics of women and men in infertile couples at the time of fertility treatment and during long-term follow-up?. Material and Methods: ReproUnion Biobank and Infertility Cohort (RUBIC) is established as an add-on to the routine fertility management at Copenhagen University Hospital Departments in the Capital Region of Denmark and Reproductive Medicine Centre at Skåne University Hospital in Sweden. The aim is to include a total of 5000 couples equally distributed between Denmark and Sweden. The first patients were enrolled in June 2020. All eligible infertile couples are prospectively asked to participate in the project. Participants complete an extensive questionnaire and undergo a physical examination and collection of biospecimens (blood, urine, hair, saliva, rectal swabs, feces, semen, endometrial biopsies, and vaginal swabs). After the cohort is established, the couples will be linked to the Danish and Swedish national registers to obtain information on parental, perinatal, childhood, and adult life histories, including disease and medication history. This will enable us to understand the causes of infertility and identify novel therapeutic options for this important societal problem.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)
Keyword
- epigenetics
- human microbiome/microbiota
- infertility
- medically assisted reproduction
- reproductive disorders
- semen quality
Publication and Content Type
- art (subject category)
- ref (subject category)
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Andrology
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- By the author/editor
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Priskorn, Lærke
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Tøttenborg, Sand ...
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Almstrup, Kristi ...
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Andersson, Anna ...
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Axelsson, Jonata ...
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Bräuner, Elvira ...
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show more...
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Elenkov, Angel
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Freiesleben, Nin ...
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Giwercman, Yvonn ...
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Grøndahl, Marie ...
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Hansen, Ann Holm
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Hansen, Laura Sm ...
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Henic, Emir
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Kitlinski, Marga ...
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Landersoe, Selma ...
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Lindh, Christian
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Løkkegaard, Elle ...
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Malm, Johan
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Olsen, Kristina ...
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Petersen, Kajsa ...
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Schmidt, Lone
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Stormlund, Sacha
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Svendsen, Pernil ...
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Vassard, Ditte
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Wang, Nathalie F ...
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Zedeler, Anne
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Bhasin, Shalende ...
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Chavarro, Jorge
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Eisenberg, Micha ...
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Hauser, Russ
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Huhtaniemi, Ilpo
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Krawetz, Stephen ...
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Marko-Varga, Gyö ...
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Salonia, Andrea
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Toppari, Jorma
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Juul, Anders
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Jørgensen, Niels
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Nielsen, Henriet ...
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Pinborg, Anja
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Rylander, Lars
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Giwercman, Aleks ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Obstetrics Gynae ...
- Articles in the publication
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Andrology
- By the university
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Lund University