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Peripheral sensory ...
Peripheral sensory neurons expressing melanopsin respond to light
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- Matynia, Anna (author)
- University of California, Los Angeles
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- Nguyen, Eileen (author)
- University of California, Los Angeles
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- Sun, Xiaoping (author)
- University of California, Los Angeles
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- Blixt, Frank W. (author)
- Lund University,Lunds universitet,Experimentell kärlforskning,Forskargrupper vid Lunds universitet,Experimental Vascular Research,Lund University Research Groups
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- Parikh, Sachin (author)
- University of California, Los Angeles
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- Kessler, Jason (author)
- University of California, Los Angeles
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- de Sevilla Müller, Luis Pérez (author)
- University of California, Los Angeles
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- Habib, Samer (author)
- University of California, Los Angeles
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- Kim, Paul (author)
- University of California, Los Angeles
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- Wang, Zhe Z. (author)
- University of California, Los Angeles
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- Rodriguez, Allen (author)
- University of California, Los Angeles
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- Charles, Andrew (author)
- University of California, Los Angeles
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- Nusinowitz, Steven (author)
- University of California, Los Angeles
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- Edvinsson, Lars (author)
- Lund University,Lunds universitet,Experimentell kärlforskning,Forskargrupper vid Lunds universitet,Experimental Vascular Research,Lund University Research Groups
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- Barnes, Steven (author)
- University of California, Los Angeles,Dalhousie University
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- Brecha, Nicholas C. (author)
- U.S. Department of Veterans Affairs,University of California, Los Angeles
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- Gorin, Michael B. (author)
- University of California, Los Angeles
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(creator_code:org_t)
- 2016-08-10
- 2016
- English.
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In: Frontiers in Neural Circuits. - : Frontiers Media SA. - 1662-5110. ; 10:AUG
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Abstract
Subject headings
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- The ability of light to cause pain is paradoxical. The retina detects light but is devoid of nociceptors while the trigeminal sensory ganglia (TG) contain nociceptors but not photoreceptors. Melanopsin-expressing intrinsically photosensitive retinal ganglion cells (ipRGCs) are thought to mediate light-induced pain but recent evidence raises the possibility of an alternative light responsive pathway independent of the retina and optic nerve. Here, we show that melanopsin is expressed in both human and mouse TG neurons. In mice, they represent 3% of small TG neurons that are preferentially localized in the ophthalmic branch of the trigeminal nerve and are likely nociceptive C fibers and high-threshold mechanoreceptor Aδ fibers based on a strong size-function association. These isolated neurons respond to blue light stimuli with a delayed onset and sustained firing, similar to the melanopsin-dependent intrinsic photosensitivity observed in ipRGCs. Mice with severe bilateral optic nerve crush exhibit no light-induced responses including behavioral light aversion until treated with nitroglycerin, an inducer of migraine in people and migraine-like symptoms in mice. With nitroglycerin, these same mice with optic nerve crush exhibit significant light aversion. Furthermore, this retained light aversion remains dependent on melanopsin-expressing neurons. Our results demonstrate a novel light-responsive neural function independent of the optic nerve that may originate in the peripheral nervous system to provide the first direct mechanism for an alternative light detection pathway that influences motivated behavior.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Oftalmologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Ophthalmology (hsv//eng)
Keyword
- Choroid
- Cornea
- IpRGC
- Migraine
- Optic nerve injury
- Sensory ganglion
Publication and Content Type
- art (subject category)
- ref (subject category)
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To the university's database
- By the author/editor
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Matynia, Anna
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Nguyen, Eileen
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Sun, Xiaoping
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Blixt, Frank W.
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Parikh, Sachin
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Kessler, Jason
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show more...
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de Sevilla Mülle ...
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Habib, Samer
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Kim, Paul
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Wang, Zhe Z.
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Rodriguez, Allen
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Charles, Andrew
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Nusinowitz, Stev ...
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Edvinsson, Lars
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Barnes, Steven
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Brecha, Nicholas ...
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Gorin, Michael B ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Ophthalmology
- Articles in the publication
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Frontiers in Neu ...
- By the university
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Lund University