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Gastrointestinal In...
Gastrointestinal Infections Modulate the Risk for Insulin Autoantibodies as the First-Appearing Autoantibody in the TEDDY Study
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- Lönnrot, Maria (author)
- Tampere University Hospital,University of Tampere
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- Lynch, Kristian F (author)
- University of South Florida
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- Rewers, Marian (author)
- University of Colorado
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- Lernmark, Åke (author)
- Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Department of Clinical Sciences, Malmö,Faculty of Medicine,Skåne University Hospital
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- Vehik, Kendra (author)
- University of South Florida
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- Akolkar, Beena (author)
- National Institute of Diabetes and Digestive and Kidney Diseases
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- Hagopian, William (author)
- Pacific Northwest Research Institute
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- Krischer, Jeffrey (author)
- University of South Florida
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- McIndoe, Rickhard A (author)
- Augusta University,Medical College of Georgia
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- Toppari, Jorma (author)
- University of Turku,Turku University Hospital
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- Ziegler, Anette-G (author)
- Helmholtz Zentrum München,Technical University of Munich
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- Petrosino, Joseph F (author)
- Baylor College of Medicine
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- Lloyd, Richard (author)
- Baylor College of Medicine
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- Hyöty, Heikki (author)
- Fimlab Laboratories,University of Tampere
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(creator_code:org_t)
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- 2023
- 2023
- English.
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In: Diabetes Care. - 1935-5548. ; 46:11, s. 1908-1915
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http://dx.doi.org/10...
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Abstract
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- OBJECTIVE: To investigate gastrointestinal infection episodes (GIEs) in relation to the appearance of islet autoantibodies in The Environmental Determinants of Diabetes in the Young (TEDDY) cohort.RESEARCH DESIGN AND METHODS: GIEs on risk of autoantibodies against either insulin (IAA) or GAD (GADA) as the first-appearing autoantibody were assessed in a 10-year follow-up of 7,867 children. Stool virome was characterized in a nested case-control study.RESULTS: GIE reports (odds ratio [OR] 2.17 [95% CI 1.39-3.39]) as well as Norwalk viruses found in stool (OR 5.69 [1.36-23.7]) at <1 year of age were associated with an increased IAA risk at 2-4 years of age. GIEs reported at age 1 to <2 years correlated with a lower risk of IAA up to 10 years of age (OR 0.48 [0.35-0.68]). GIE reports at any other age were associated with an increase in IAA risk (OR 2.04 for IAA when GIE was observed 12-23 months prior [1.41-2.96]). Impacts on GADA risk were limited to GIEs <6 months prior to autoantibody development in children <4 years of age (OR 2.16 [1.54-3.02]).CONCLUSIONS: Bidirectional associations were observed. GIEs were associated with increased IAA risk when reported before 1 year of age or 12-23 months prior to IAA. Norwalk virus was identified as one possible candidate factor. GIEs reported during the 2nd year of life were associated with a decreased IAA risk.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
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- art (subject category)
- ref (subject category)
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- By the author/editor
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Lönnrot, Maria
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Lynch, Kristian ...
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Rewers, Marian
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Lernmark, Åke
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Vehik, Kendra
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Akolkar, Beena
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show more...
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Hagopian, Willia ...
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Krischer, Jeffre ...
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McIndoe, Rickhar ...
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Toppari, Jorma
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Ziegler, Anette- ...
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Petrosino, Josep ...
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Lloyd, Richard
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Hyöty, Heikki
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
- Articles in the publication
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Diabetes Care
- By the university
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Lund University