Search: onr:"swepub:oai:lup.lub.lu.se:cfbc4fe6-542a-4882-abab-22e383ff19a2" >
Cardiac Natriuretic...
-
Khan, Abigail May
(author)
Cardiac Natriuretic Peptides, Obesity, and Insulin Resistance: Evidence from Two Community-Based Studies.
- Article/chapterEnglish2011
Publisher, publication year, extent ...
-
The Endocrine Society,2011
-
electronicrdacarrier
Numbers
-
LIBRIS-ID:oai:lup.lub.lu.se:cfbc4fe6-542a-4882-abab-22e383ff19a2
-
https://lup.lub.lu.se/record/2150901URI
-
https://doi.org/10.1210/jc.2011-1182DOI
Supplementary language notes
-
Language:English
-
Summary in:English
Part of subdatabase
Classification
-
Subject category:art swepub-publicationtype
-
Subject category:ref swepub-contenttype
Notes
-
Background: The natriuretic peptides play an important role in salt homeostasis and blood pressure regulation. It has been suggested that obesity promotes a relative natriuretic peptide deficiency, but this has been a variable finding in prior studies and the cause is unknown. Aim: The aim of this study was to examine the association between obesity and natriuretic peptide levels and evaluate the role of hyperinsulinemia and testosterone as mediators of this interaction. Methods: We studied 7770 individuals from the Framingham Heart Study (n = 3833, 54% women) and the Malmö Diet and Cancer study (n = 3918, 60% women). We examined the relation of plasma N-terminal pro-B-type natriuretic peptide levels (N-BNP) with obesity, insulin resistance, and various metabolic subtypes. Results: Obesity was associated with 6-20% lower levels of N-BNP (P < 0.001 in Framingham, P = 0.001 in Malmö), whereas insulin resistance was associated with 10-30% lower levels of N-BNP (P < 0.001 in both cohorts). Individuals with obesity who were insulin sensitive had only modest reductions in N-BNP compared with nonobese, insulin-sensitive individuals. On the other hand, individuals who were nonobese but insulin resistant had 26% lower N-BNP in Framingham (P < 0.001) and 10% lower N-BNP in Malmö (P < 0.001), compared with nonobese and insulin-sensitive individuals. Adjustment for serum-free testosterone did not alter these associations. Conclusions: In both nonobese and obese individuals, insulin resistance is associated with lower natriuretic peptide levels. The relative natriuretic peptide deficiency seen in obesity could be partly attributable to insulin resistance, and could be one mechanism by which insulin resistance promotes hypertension.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
-
Cheng, Susan
(author)
-
Magnusson, MartinLund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups(Swepub:lu)medf-mma
(author)
-
Larson, Martin G
(author)
-
Newton-Cheh, Christopher
(author)
-
McCabe, Elizabeth L
(author)
-
Coviello, Andrea D
(author)
-
Florez, Jose C
(author)
-
Fox, Caroline S
(author)
-
Levy, Daniel
(author)
-
Robins, Sander J
(author)
-
Arora, Pankaj
(author)
-
Bhasin, Shalender
(author)
-
Lam, Carolyn S P
(author)
-
Vasan, Ramachandran S
(author)
-
Melander, OlleLund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups(Swepub:lu)endo-ome
(author)
-
Wang, Thomas J
(author)
-
Kardiovaskulär forskning - hypertoniForskargrupper vid Lunds universitet
(creator_code:org_t)
Related titles
-
In:The Journal of clinical endocrinology and metabolism: The Endocrine Society96:10, s. 3242-32491945-71970021-972X
Internet link
Find in a library
To the university's database
- By the author/editor
-
Khan, Abigail Ma ...
-
Cheng, Susan
-
Magnusson, Marti ...
-
Larson, Martin G
-
Newton-Cheh, Chr ...
-
McCabe, Elizabet ...
-
show more...
-
Coviello, Andrea ...
-
Florez, Jose C
-
Fox, Caroline S
-
Levy, Daniel
-
Robins, Sander J
-
Arora, Pankaj
-
Bhasin, Shalende ...
-
Lam, Carolyn S P
-
Vasan, Ramachand ...
-
Melander, Olle
-
Wang, Thomas J
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Endocrinology an ...
- Articles in the publication
-
The Journal of c ...
- By the university
-
Lund University