Search: onr:"swepub:oai:lup.lub.lu.se:d12e8fbf-efaa-41c2-adf3-c26d058924f7" >
Characterization of...
-
Callesen, Katrine T.Copenhagen University Hospital
(author)
Characterization of Mast Cells from Healthy and Varicose Human Saphenous Vein
- Article/chapterEnglish2022
Publisher, publication year, extent ...
Numbers
-
LIBRIS-ID:oai:lup.lub.lu.se:d12e8fbf-efaa-41c2-adf3-c26d058924f7
-
https://lup.lub.lu.se/record/d12e8fbf-efaa-41c2-adf3-c26d058924f7URI
-
https://doi.org/10.3390/biomedicines10051062DOI
Supplementary language notes
-
Language:English
-
Summary in:English
Part of subdatabase
Classification
-
Subject category:art swepub-publicationtype
-
Subject category:ref swepub-contenttype
Notes
-
Mast cells (MCs) are distributed in tissues throughout the body and are highly involved in many physiological and pathophysiological processes. The potential and involvement of different MC phenotypes are still not well understood. MCs are present in blood vessel walls, but their specific phenotypic features are unknown. We aimed at characterizing MCs from human saphenous veins for localization, mediator content, and receptor expression. This was done in MCs from both healthy and varicose human saphenous veins (hSV and vSV, respectively). For both vSV and hSV, we found that vein MCs are mainly present in the tunica adventitia (99% MCs in adventitia) and that the population consists of both MCT and MCTC phenotypes (vSV: 55% MCT, hSV: 64% MCT). The vein MCs contained high levels of histamine (vSV: 27 pg/MC, hSV: 55 pg/MC) and tryptase (vSV: 98 pg/MC, hSV: 111 pg/MC), indicating a strong potential for regulatory effects on blood vessels. The receptor expression of FcɛRI, MRGPRX2, PTAFR, C3aR, and C5aR was found, even though the percentage of positive cells differed between vSV and hSV MCs. We conclude that vein MCs from the blood vessel wall have a high potential to affect the tissue around them.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
-
Mogren, SofiaLund University,Lunds universitet,Respiratorisk cellbiologi,Forskargrupper vid Lunds universitet,Respiratory Cell Biology,Lund University Research Groups(Swepub:lu)so0187mo
(author)
-
Berlin, FridaLund University,Lunds universitet,Respiratorisk cellbiologi,Forskargrupper vid Lunds universitet,Respiratory Cell Biology,Lund University Research Groups(Swepub:lu)fr4827be
(author)
-
Andersson, CeciliaLund University,Lunds universitet,Respiratorisk cellbiologi,Forskargrupper vid Lunds universitet,Respiratory Cell Biology,Lund University Research Groups(Swepub:lu)ce4613an
(author)
-
Schmidt, SusanneCopenhagen University Hospital
(author)
-
Klitfod, LotteGentofte Hospital
(author)
-
Esteban, VanesaHospital Fundación Jiménez Díaz
(author)
-
Poulsen, Lars K.Copenhagen University Hospital
(author)
-
Jensen, Bettina M.Copenhagen University Hospital
(author)
-
Copenhagen University HospitalRespiratorisk cellbiologi
(creator_code:org_t)
Related titles
-
In:Biomedicines: MDPI AG10:52227-9059
Internet link
Find in a library
To the university's database