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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04843naa a2200409 4500 | |
| 001 | oai:lup.lub.lu.se:d17f119d-5457-4a3a-a338-7fbbee42347e | |
| 003 | SwePub | |
| 008 | 160401s2003 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://lup.lub.lu.se/record/1157132 URI |
| 024 | 7 | a https://doi.org/10.1046/j.1460-9568.2003.02713.x2 DOI |
| 040 | a (SwePub)lu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a art2 swepub-publicationtype |
| 072 | 7 | a ref2 swepub-contenttype |
| 100 | 1 | a Gustafsson, Elin4 aut |
| 245 | 1 0 | a Anterograde delivery of brain-derived neurotrophic factor to striatum via nigral transduction of recombinant adeno-associated virus increases neuronal death but promotes neurogenic response following stroke. |
| 264 | c 2003-06-23 | |
| 264 | 1 | b Wiley,c 2003 |
| 338 | a electronic2 rdacarrier | |
| 520 | a o explore the role of brain-derived neurotrophic factor for survival and generation of striatal neurons after stroke, recombinant adeno-associated viral vectors carrying brain-derived neurotrophic factor or green fluorescent protein genes were injected into right rat substantia nigra 4–5 weeks prior to 30 min ipsilateral of middle cerebral artery occlusion. The brain-derived neurotrophic factor–recombinant adeno-associated viral transduction markedly increased the production of brain-derived neurotrophic factor protein by nigral cells. Brain-derived neurotrophic factor was transported anterogradely to the striatum and released in biologically active form, as revealed by the hypertrophic response of striatal neuropeptide Y-positive interneurons. Animals transduced with brain-derived neurotrophic factor-recombinant adeno-associated virus also exhibited abnormalities in body posture and movements, including tilted body to the right, choreiform movements of left forelimb and head, and spontaneous, so-called 'barrel' rotation along their long axis. The continuous delivery of brain-derived neurotrophic factor had no effect on the survival of striatal projection neurons after stroke, but exaggerated the loss of cholinergic, and parvalbumin- and neuropeptide Y-positive, γ-aminobutyric acid-ergic interneurons. The high brain-derived neurotrophic factor levels in the animals subjected to stroke also gave rise to an increased number of striatal cells expressing doublecortin, a marker for migrating neuroblasts, and cells double-labelled with the mitotic marker, 5-bromo-2'-deoxyuridine-5'monophosphate, and early neuronal (Hu) or striatal neuronal (Meis2) markers. Our findings indicate that long-term anterograde delivery of high levels of brain-derived neurotrophic factor increases the vulnerability of striatal interneurons to stroke-induced damage. Concomitantly, brain-derived neurotrophic factor potentiates the stroke-induced neurogenic response, at least at early stages. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng |
| 700 | 1 | a Andsberg, Gunnaru Lund University,Lunds universitet,Wallenberg Neurocentrum, Lund,Medicinska fakulteten,Wallenberg Neuroscience Centre, Lund,Faculty of Medicine4 aut0 (Swepub:lu)neur-gan |
| 700 | 1 | a Darsalia, Vladimeru Lund University,Lunds universitet,Wallenberg Neurocentrum, Lund,Medicinska fakulteten,Wallenberg Neuroscience Centre, Lund,Faculty of Medicine4 aut0 (Swepub:lu)neur-vda |
| 700 | 1 | a Mohapel, Paulu Lund University,Lunds universitet,Wallenberg Neurocentrum, Lund,Medicinska fakulteten,Wallenberg Neuroscience Centre, Lund,Faculty of Medicine4 aut0 (Swepub:lu)neur-pmo |
| 700 | 1 | a Mandel, Ronald J.4 aut |
| 700 | 1 | a Kirik, Denizu Lund University,Lunds universitet,Neurobiologi,Forskargrupper vid Lunds universitet,Neurobiology,Lund University Research Groups4 aut0 (Swepub:lu)mphy-dki |
| 700 | 1 | a Lindvall, Olleu Lund University,Lunds universitet,Wallenberg Neurocentrum, Lund,Medicinska fakulteten,Wallenberg Neuroscience Centre, Lund,Faculty of Medicine4 aut0 (Swepub:lu)neur-oli |
| 700 | 1 | a Kokaia, Zaalu Lund University,Lunds universitet,Wallenberg Neurocentrum, Lund,Medicinska fakulteten,Wallenberg Neuroscience Centre, Lund,Faculty of Medicine4 aut0 (Swepub:lu)neur-zko |
| 710 | 2 | a Wallenberg Neurocentrum, Lundb Medicinska fakulteten4 org |
| 773 | 0 | t European Journal of Neuroscienced : Wileyg 17:12, s. 2667-2678q 17:12<2667-2678x 1460-9568x 0953-816X |
| 856 | 4 | u https://portal.research.lu.se/files/2829540/623808.pdfx primaryx freey FULLTEXT |
| 856 | 4 | u http://dx.doi.org/10.1046/j.1460-9568.2003.02713.xy FULLTEXT |
| 856 | 4 | u https://lup.lub.lu.se/search/files/2829540/623808.pdf |
| 856 | 4 8 | u https://lup.lub.lu.se/record/115713 |
| 856 | 4 8 | u https://doi.org/10.1046/j.1460-9568.2003.02713.x |
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