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Individual progress...
Individual progression of carotid intima media thickness as a surrogate for vascular risk (PROG-IMT): Rationale and design of a meta-analysis project
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Lorenz, Matthias W. (author)
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Bickel, Horst (author)
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Bots, Michiel L. (author)
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Breteler, Monique M. B. (author)
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Catapano, Alberico L. (author)
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Desvarieux, Moise (author)
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- Hedblad, Bo (author)
- Lund University,Lunds universitet,Kardiovaskulär forskning - epidemiologi,Forskargrupper vid Lunds universitet,Cardiovascular Research - Epidemiology,Lund University Research Groups
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Iglseder, Bernhard (author)
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Johnsen, Stein Harald (author)
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Juraska, Michal (author)
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Kiechl, Stefan (author)
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Mathiesen, Ellisiv B. (author)
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Norata, Giuseppe D. (author)
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Grigore, Liliana (author)
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Polak, Joseph (author)
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Poppert, Holger (author)
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- Rosvall, Maria (author)
- Lund University,Lunds universitet,Socialepidemiologi,Forskargrupper vid Lunds universitet,Social Epidemiology,Lund University Research Groups
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Rundek, Tatjana (author)
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Sacco, Ralph L. (author)
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Sander, Dirk (author)
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Sitzer, Matthias (author)
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Steinmetz, Helmuth (author)
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Stensland, Eva (author)
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Willeit, Johann (author)
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Witteman, Jacqueline (author)
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Yanez, David (author)
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Thompson, Simon G. (author)
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(creator_code:org_t)
- Elsevier BV, 2010
- 2010
- English.
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In: American Heart Journal. - : Elsevier BV. - 1097-6744 .- 0002-8703. ; 159:5, s. 25-730
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http://dx.doi.org/10...
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Abstract
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- Carotid intima media thickness (IMT) progression is increasingly used as a surrogate for vascular risk. This use is supported by data from a few clinical trials investigating statins, but established criteria of surrogacy are only partially fulfilled. To provide a valid basis for the use of IMT progression as a study end point, we are performing a 3-step meta-analysis project based on individual participant data. Objectives of the 3 successive stages are to investigate (1) whether IMT progression prospectively predicts myocardial infarction, stroke, or death in population-based samples; (2) whether it does so in prevalent disease cohorts; and (3) whether interventions affecting IMT progression predict a therapeutic effect on clinical end points. Recruitment strategies, inclusion criteria, and estimates of the expected numbers of eligible studies are presented along with a detailed analysis plan. (Am Heart J 2010; 159: 730-736.e2.)
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Lorenz, Matthias ...
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Bickel, Horst
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Bots, Michiel L.
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Breteler, Moniqu ...
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Catapano, Alberi ...
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Desvarieux, Mois ...
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show more...
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Hedblad, Bo
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Iglseder, Bernha ...
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Johnsen, Stein H ...
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Juraska, Michal
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Kiechl, Stefan
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Mathiesen, Ellis ...
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Norata, Giuseppe ...
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Grigore, Liliana
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Polak, Joseph
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Poppert, Holger
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Rosvall, Maria
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Rundek, Tatjana
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Sacco, Ralph L.
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Sander, Dirk
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Sitzer, Matthias
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Steinmetz, Helmu ...
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Stensland, Eva
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Willeit, Johann
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Witteman, Jacque ...
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Yanez, David
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Thompson, Simon ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
- Articles in the publication
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American Heart J ...
- By the university
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Lund University