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  • McKeown, Nicola M.Tufts University (author)

Sugar-sweetened beverage intake associations with fasting glucose and insulin concentrations are not modified by selected genetic variants in a ChREBP-FGF21 pathway : a meta-analysis

  • Article/chapterEnglish2018

Publisher, publication year, extent ...

  • 2017-11-02
  • Springer Science and Business Media LLC,2018

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:d26e758b-cc13-4037-8ca0-c0e08ab5fdc1
  • https://lup.lub.lu.se/record/d26e758b-cc13-4037-8ca0-c0e08ab5fdc1URI
  • https://doi.org/10.1007/s00125-017-4475-0DOI

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  • Language:English
  • Summary in:English

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  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Aims/hypothesis: Sugar-sweetened beverages (SSBs) are a major dietary contributor to fructose intake. A molecular pathway involving the carbohydrate responsive element-binding protein (ChREBP) and the metabolic hormone fibroblast growth factor 21 (FGF21) may influence sugar metabolism and, thereby, contribute to fructose-induced metabolic disease. We hypothesise that common variants in 11 genes involved in fructose metabolism and the ChREBP-FGF21 pathway may interact with SSB intake to exacerbate positive associations between higher SSB intake and glycaemic traits. Methods: Data from 11 cohorts (six discovery and five replication) in the CHARGE (Cohorts for Heart and Aging Research in Genomic Epidemiology) Consortium provided association and interaction results from 34,748 adults of European descent. SSB intake (soft drinks, fruit punches, lemonades or other fruit drinks) was derived from food-frequency questionnaires and food diaries. In fixed-effects meta-analyses, we quantified: (1) the associations between SSBs and glycaemic traits (fasting glucose and fasting insulin); and (2) the interactions between SSBs and 18 independent SNPs related to the ChREBP-FGF21 pathway. Results: In our combined meta-analyses of discovery and replication cohorts, after adjustment for age, sex, energy intake, BMI and other dietary covariates, each additional serving of SSB intake was associated with higher fasting glucose (β ± SE 0.014 ± 0.004 [mmol/l], p = 1.5 × 10−3) and higher fasting insulin (0.030 ± 0.005 [loge pmol/l], p = 2.0 × 10−10). No significant interactions on glycaemic traits were observed between SSB intake and selected SNPs. While a suggestive interaction was observed in the discovery cohorts with a SNP (rs1542423) in the β-Klotho (KLB) locus on fasting insulin (0.030 ± 0.011 loge pmol/l, uncorrected p = 0.006), results in the replication cohorts and combined meta-analyses were non-significant. Conclusions/interpretation: In this large meta-analysis, we observed that SSB intake was associated with higher fasting glucose and insulin. Although a suggestive interaction with a genetic variant in the ChREBP-FGF21 pathway was observed in the discovery cohorts, this observation was not confirmed in the replication analysis. Trial registration: Trials related to this study were registered at clinicaltrials.govas NCT00005131 (Atherosclerosis Risk in Communities), NCT00005133 (Cardiovascular Health Study), NCT00005121 (Framingham Offspring Study), NCT00005487 (Multi-Ethnic Study of Atherosclerosis) and NCT00005152 (Nurses’ Health Study).

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  • Dashti, Hassan S.Tufts University,Broad Institute,Massachusetts General Hospital (author)
  • Ma, JiantaoNational Heart Lung and Blood Institute (author)
  • Haslam, Danielle E.Tufts University (author)
  • Kiefte-de Jong, Jessica C.Leiden University,Erasmus University Medical Center (author)
  • Smith, Caren E.Tufts University (author)
  • Tanaka, ToshikoNational Institute on Aging, United States (author)
  • Graff, MariaelisaUniversity of North Carolina (author)
  • Lemaitre, Rozenn N.University of Washington (author)
  • Rybin, DenisBoston University (author)
  • Sonestedt, EmilyLund University,Lunds universitet,Nutritionsepidemiologi,Forskargrupper vid Lunds universitet,Nutrition Epidemiology,Lund University Research Groups(Swepub:lu)medf-eso (author)
  • Frazier-Wood, Alexis C.Baylor College of Medicine (author)
  • Mook-Kanamori, Dennis O.Leiden University Medical Centre (author)
  • Li, YanpingHarvard University (author)
  • Wang, Carol A.University of Western Australia, Crawley (author)
  • Leermakers, Elisabeth T.M.Erasmus University Medical Center (author)
  • Mikkilä, VeraUniversity of Turku,University of Helsinki (author)
  • Young, Kristin L.University of North Carolina (author)
  • Mukamal, Kenneth J.Beth Israel Deaconess Medical Center (author)
  • Cupples, L. AdrienneBoston University,National Heart Lung and Blood Institute (author)
  • Schulz, Christina AlexandraLund University,Lunds universitet,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,Diabetes - Cardiovascular Disease,Lund University Research Groups(Swepub:lu)med-csc (author)
  • Chen, Tzu AnBaylor College of Medicine (author)
  • Li-Gao, RuifangLeiden University Medical Centre (author)
  • Huang, TaoHarvard University (author)
  • Oddy, Wendy H.Telethon Kids Institute,University of Tasmania (author)
  • Raitakari, OlliUniversity of Turku,Turku University Hospital (author)
  • Rice, KennethUniversity of Washington (author)
  • Meigs, James B.Massachusetts General Hospital,Broad Institute,Harvard Medical School (author)
  • Ericson, UlrikaLund University,Lunds universitet,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,Diabetes - Cardiovascular Disease,Lund University Research Groups(Swepub:lu)medf-upe (author)
  • Steffen, Lyn M.University of Minnesota (author)
  • Rosendaal, Frits R.Leiden University Medical Centre (author)
  • Hofman, AlbertErasmus University Medical Center (author)
  • Kähönen, MikaTampere University Hospital (author)
  • Psaty, Bruce M.Kaiser Permanente Research Institute,University of Washington (author)
  • Brunkwall, LouiseLund University,Lunds universitet,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,Diabetes - Cardiovascular Disease,Lund University Research Groups(Swepub:lu)med-lbw (author)
  • Uitterlinden, Andre G.Erasmus University Medical Center (author)
  • Viikari, JormaUniversity of Turku,Turku University Hospital (author)
  • Siscovick, David S.New York Academy of Medicine (author)
  • Seppälä, IlkkaUniversity of Tampere (author)
  • North, Kari E.University of North Carolina (author)
  • Mozaffarian, DariushTufts University (author)
  • Dupuis, JoséeBoston University,National Heart Lung and Blood Institute (author)
  • Orho-Melander, MarjuLund University,Lunds universitet,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,Diabetes - Cardiovascular Disease,Lund University Research Groups(Swepub:lu)endo-mor (author)
  • Rich, Stephen S.University of Virginia (author)
  • de Mutsert, RenéeLeiden University Medical Centre (author)
  • Qi, LuHarvard University (author)
  • Pennell, Craig E.University of Western Australia, Crawley (author)
  • Franco, Oscar H.Erasmus University Medical Center (author)
  • Lehtimäki, TerhoTufts University (author)
  • Herman, Mark A.Duke University (author)
  • Tufts UniversityBroad Institute (creator_code:org_t)

Related titles

  • In:Diabetologia: Springer Science and Business Media LLC61:2, s. 317-3300012-186X1432-0428

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