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- Giri, AyushVanderbilt University (author)
Trans-ethnic association study of blood pressure determinants in over 750,000 individuals
- Article/chapterEnglish2019
Publisher, publication year, extent ...
- 2018-12-21
- Springer Science and Business Media LLC,2019
- 12 s.
Numbers
- LIBRIS-ID:oai:lup.lub.lu.se:d28b8d79-9174-4253-ae9e-845b2add5318
- https://lup.lub.lu.se/record/d28b8d79-9174-4253-ae9e-845b2add5318URI
- https://doi.org/10.1038/s41588-018-0303-9DOI
Supplementary language notes
- Language:English
- Summary in:English
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- SwePubSwePub
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Notes
- In this trans-ethnic multi-omic study, we reinterpret the genetic architecture of blood pressure to identify genes, tissues, phenomes and medication contexts of blood pressure homeostasis. We discovered 208 novel common blood pressure SNPs and 53 rare variants in genome-wide association studies of systolic, diastolic and pulse pressure in up to 776,078 participants from the Million Veteran Program (MVP) and collaborating studies, with analysis of the blood pressure clinical phenome in MVP. Our transcriptome-wide association study detected 4,043 blood pressure associations with genetically predicted gene expression of 840 genes in 45 tissues, and mouse renal single-cell RNA sequencing identified upregulated blood pressure genes in kidney tubule cells. © 2018, The Author(s), under exclusive licence to Springer Nature America, Inc.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Medicinsk genetik hsv//swe
- MEDICAL AND HEALTH SCIENCES Basic Medicine Medical Genetics hsv//eng
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Kardiologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Cardiac and Cardiovascular Systems hsv//eng
Added entries (persons, corporate bodies, meetings, titles ...)
- Almgren, PeterLund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups(Swepub:lu)endo-pal (author)
- Melander, OlleLund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups(Swepub:lu)endo-ome (author)
- Hung, Adriana M.Vanderbilt University (author)
- Edwards, Todd LVanderbilt University (author)
- Vanderbilt UniversityKardiovaskulär forskning - hypertoni (creator_code:org_t)
- International Consortium for Blood Pressure
Related titles
- In:Nature Genetics: Springer Science and Business Media LLC51:1, s. 51-621546-17181061-4036
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