Search: onr:"swepub:oai:lup.lub.lu.se:d306b1c1-2d8b-451d-832b-eed34953007a" >
Improved removal of...
Improved removal of anti-A and anti-B antibodies from plasma using blood-group-active haptens
- Article/chapterEnglish1993
Publisher, publication year, extent ...
Numbers
-
LIBRIS-ID:oai:lup.lub.lu.se:d306b1c1-2d8b-451d-832b-eed34953007a
-
https://lup.lub.lu.se/record/1107152URI
Supplementary language notes
-
Language:English
-
Summary in:English
Part of subdatabase
Classification
-
Subject category:art swepub-publicationtype
-
Subject category:ref swepub-contenttype
Notes
-
Highly efficient anti-blood group A and B immunoadsorbents for extracorporeal treatment were developed by immobilizing A and B trisaccharide and A tetrasaccharide haptens on Sepharose 4FF and Fractogel TSK using three different methods. The adsorption of the IgG and IgM anti-A antibodies was essentially the same regardless of the A hapten used or the method of oligosaccharide coupling. The adsorption of IgM anti-A was found to be more sensitive than IgG anti-A to changes in column flow rate. The binding of both the IgM and IgG antibodies was slightly lower at 37 degrees C than at 22 degrees C. An anti-A/anti-B adsorbent column potentially suitable for treatment of patients was prepared. A column switching system resulted in a more efficient adsorption of antibodies. Hapten leakage from the column was very low. No nonspecific adsorption of plasma proteins to the column (other than traces of albumin) could be detected.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
-
Bratt, T
(author)
-
Chester, AlanLund University,Lunds universitet,Avdelningen för hematologi och transfusionsmedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Hematology and Transfusion Medicine,Department of Laboratory Medicine,Faculty of Medicine(Swepub:lu)labm-ac
(author)
-
Hansson, B
(author)
-
Avdelningen för hematologi och transfusionsmedicinInstitutionen för laboratoriemedicin
(creator_code:org_t)
Related titles
-
In:Vox Sanguinis65:2, s. 126-1351423-0410
Internet link
Find in a library
To the university's database