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Search: onr:"swepub:oai:lup.lub.lu.se:d320706b-699c-435d-aa31-ab1e105d2ca5" > Spatial Deconvoluti...

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Spatial Deconvolution of HER2-positive Breast Tumors Reveals Novel Intercellular Relationships

Andersson, Alma (author)
KTH Royal Institute of Technology,Science for Life Laboratory (SciLifeLab)
Larsson, Ludvig (author)
KTH Royal Institute of Technology
Stenbeck, Linnea (author)
KTH Royal Institute of Technology,Science for Life Laboratory (SciLifeLab)
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Salmén, Fredrik (author)
KTH Royal Institute of Technology,University Medical Center Utrecht
Ehinger, Anna (author)
Lund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Patologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Pathology, Lund,Section V,Department of Clinical Sciences, Lund,Blekinge Hospital
Wu, Sunny (author)
The Kinghorne Cancer Centre,University of Sydney
Al-Eryani, Ghamdan (author)
The Kinghorne Cancer Centre
Roden, Daniel (author)
The Kinghorne Cancer Centre
Swarbrick, Alex (author)
Borg, Åke (author)
Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Familjär bröstcancer,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Familial Breast Cancer,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Blekinge Hospital
Frisén, Jonas (author)
Karolinska Institutet
Engblom, Camilla (author)
Karolinska Institutet
Lundeberg, Joakim (author)
KTH Royal Institute of Technology
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 (creator_code:org_t)
Cold Spring Harbor Laboratory, 2020
English.
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Abstract Subject headings
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  • In the past decades, transcriptomic studies have revolutionized cancer treatment and diagnosis. However, tumor sequencing strategies typically result in loss of spatial information, critical to understand cell interactions and their functional relevance. To address this, we investigate spatial gene expression in HER2-positive breast tumors using Spatial Transcriptomics technology. We show that expression-based clustering enables data-driven tumor annotation and assessment of intra-and interpatient heterogeneity; from which we discover shared gene signatures for immune and tumor processes. We integrate and spatially map tumor-associated types from single cell data to find: segregated epithelial cells, interactions between B and T-cells and myeloid cells, co-localization of macrophage and T-cell subsets. A model is constructed to infer presence of tertiary lymphoid structures, applicable across tissue types and technical platforms. Taken together, we combine different data modalities to define novel interactions between tumor-infiltrating cells in breast cancer and provide tools generalizing across tissues and diseases.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)

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