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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00008428nam a2200565 4500
001oai:lup.lub.lu.se:d3297a5c-fa11-4ff2-90ea-431213939e98
003SwePub
008221010s2021 | |||||||||||000 ||eng|
0247 a https://lup.lub.lu.se/record/d3297a5c-fa11-4ff2-90ea-431213939e982 URI
0247 a https://doi.org/10.1101/2021.04.28.212562612 DOI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a ovr2 swepub-publicationtype
072 7a vet2 swepub-contenttype
1001 a Drew, David A.u Massachusetts General Hospital4 aut
2451 0a Aspirin and NSAID use and the risk of COVID-19
264 1b Cold Spring Harbor Laboratory,c 2021
520 a Early reports raised concern that use of non-steroidal anti-inflammatory drugs (NSAIDs) may increase risk of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) disease (COVID-19). Users of the COVID Symptom Study smartphone application reported use of aspirin and other NSAIDs between March 24 and May 8, 2020. Users were queried daily about symptoms, COVID-19 testing, and healthcare seeking behavior. Cox proportional hazards regression was used to determine the risk of COVID-19 among according to aspirin or non-aspirin NSAID users. Among 2,736,091 individuals in the U.S., U.K., and Sweden, we documented 8,966 incident reports of a positive COVID-19 test over 60,817,043 person-days of follow-up. Compared to non-users and after stratifying by age, sex, country, day of study entry, and race/ethnicity, non-aspirin NSAID use was associated with a modest risk for testing COVID-19 positive (HR 1.23 [1.09, 1.32]), but no significant association was observed among aspirin users (HR 1.13 [0.92, 1.38]). After adjustment for lifestyle factors, comorbidities and baseline symptoms, any NSAID use was not associated with risk (HR 1.02 [0.94, 1.10]). Results were similar for those seeking healthcare for COVID-19 and were not substantially different according to lifestyle and sociodemographic factors or after accounting for propensity to receive testing. Our results do not support an association of NSAID use, including aspirin, with COVID-19 infection. Previous reports of a potential association may be due to higher rates of comorbidities or use of NSAIDs to treat symptoms associated with COVID-19.One Sentence Summary NSAID use is not associated with COVID-19 risk.Competing Interest StatementJW, RD, and JC are employees of Zoe Global Ltd. TDS is a consultant to Zoe Global Ltd. DAD and ATC previously served as investigators on a clinical trial of diet and lifestyle using a separate mobile application that was supported by Zoe Global Ltd. Other authors have no conflict of interest to declare.Clinical TrialNCT04331509Funding StatementZoe provided in kind support for all aspects of building running and supporting the app and service to all users worldwide. DAD is supported by the National Institute of Diabetes and Digestive and Kidney Diseases K01DK120742. CGG is supported by the Bau Tsu Zung Bau Kwan Yeu Hing Research and Clinical Fellowship. LHN is supported by the American Gastroenterological Association Research Scholars Award. ATC is the Stuart and Suzanne Steele MGH Research Scholar and Stand Up to Cancer scientist. The Massachusetts Consortium on Pathogen Readiness (MassCPR) and Mark and Lisa Schwartz supported MGH investigators (DAD CGG LHN ADJ WM RSM CHL SK ATC). CMA is supported by the NIDDK K23 DK120899 and the Boston Childrens Hospital Office of Faculty Development Career Development Award. Kings College of London investigators (KAL MNL TV MSG CHS SO CJS TDS) were supported by the Wellcome Trust and EPSRC (WT212904/Z/18/Z WT203148/Z/16/Z T213038/Z/18/Z) the NIHR GSTT/KCL Biomedical Research Centre MRC/BHF (MR/M016560/1) UK Research and Innovation London Medical Imaging and Artificial Intelligence Centre for Value Based Healthcare and the Alzheimers Society (AS-JF-17-011). MNL is supported by an NIHR Doctoral Fellowship (NIHR300159). Work related to the Swedish elements of the study are supported by grants from the Swedish Research Council, Swedish Heart-Lung Foundation and the Swedish Foundation for Strategic Research (LUDC-IRC 15-0067). Sponsors had no role in study design analysis and interpretation of data report writing and the decision to submit for publication.Author DeclarationsI confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.YesThe details of the IRB/oversight body that provided approval or exemption for the research described are given below:Participants provided informed consent to the use of app data for research purposes and agreed to privacy policies and terms of use. This research study was approved by the Partners Human Research Committee IRB 2020P000909 Kings College London Ethics Committee REMAS ID 18210 Review Reference LRS-19/20-18210 and the central ethics committee in Sweden DNR 2020-01803All necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived.YesI understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance).YesI have followed all appropriate research reporting guidelines and uploaded the relevant EQUATOR Network research reporting checklist(s) and other pertinent material as supplementary files, if applicable.YesData collected in the app is being shared with other health researchers through the NHS-funded Health Data Research U.K. (HDRUK)/SAIL consortium, housed in the U.K. Secure Research Platform (UKSeRP) in Swansea. Anonymized data is available to be shared with bonafide researchers HDRUK according to their protocols (https://healthdatagateway.org/detail/9b604483-9cdc-41b2-b82c-14ee3dd705f6). U.S. investigators are encouraged to coordinate data requests through the COPE Consortium (www.monganinstitute.org/cope-consortium). Data updates can be found on https://covid.joinzoe.com.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Infektionsmedicin0 (SwePub)302092 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Infectious Medicine0 (SwePub)302092 hsv//eng
7001 a Guo, Chuan-Guou University of Hong Kong4 aut
7001 a Lee, Karla A.u King's College London4 aut
7001 a Nguyen, Long H.u Harvard T.H. Chan School of Public Health4 aut
7001 a Joshi, Amit D.u Harvard Medical School4 aut
7001 a Lo, Chun-Hanu Harvard T.H. Chan School of Public Health4 aut
7001 a Ma, Wenjie4 aut
7001 a Mehta, Raaj S.4 aut
7001 a Kwon, Sohee4 aut
7001 a Astley, Christina M.u Broad Institute4 aut
7001 a Song, Mingyang4 aut
7001 a Davies, Richard4 aut
7001 a Capdevila, Joanu Zoe Global Limited4 aut
7001 a Lochlainn, Mary Ni4 aut
7001 a Sudre, Carole H.4 aut
7001 a Graham, Mark S.4 aut
7001 a Varsavsky, Thomas4 aut
7001 a Gomez, Maria F.u Lund University,Lunds universitet,Diabetiska komplikationer,Forskargrupper vid Lunds universitet,Diabetic Complications,Lund University Research Groups4 aut0 (Swepub:lu)mphy-mgo
7001 a Kennedy, Beatriceu Uppsala University4 aut
7001 a Fitipaldi, Hugou Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups4 aut0 (Swepub:lu)hu3745fi
7001 a Wolf, Jonathan4 aut
7001 a Spector, Tim D.4 aut
7001 a Ourselin, Sebastien4 aut
7001 a Steves, Claire J.u King's College London4 aut
7001 a Chan, Andrew T.4 aut
7102 a Massachusetts General Hospitalb University of Hong Kong4 org
8564 u http://dx.doi.org/10.1101/2021.04.28.21256261x freey FULLTEXT
8564 u https://www.medrxiv.org/content/medrxiv/early/2021/05/02/2021.04.28.21256261.full.pdf
8564 8u https://lup.lub.lu.se/record/d3297a5c-fa11-4ff2-90ea-431213939e98
8564 8u https://doi.org/10.1101/2021.04.28.21256261

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