Search: onr:"swepub:oai:lup.lub.lu.se:d35474ab-67c1-4f01-8a9b-db3f2291a1b6" > Leukocyte telomere ...
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000 | 05424naa a2200865 4500 | |
001 | oai:lup.lub.lu.se:d35474ab-67c1-4f01-8a9b-db3f2291a1b6 | |
003 | SwePub | |
008 | 160401s2014 | |||||||||||000 ||eng| | |
009 | oai:prod.swepub.kib.ki.se:130135318 | |
009 | oai:DiVA.org:umu-97595 | |
024 | 7 | a https://lup.lub.lu.se/record/46153832 URI |
024 | 7 | a https://doi.org/10.1158/1055-9965.EPI-14-02472 DOI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1301353182 URI |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-975952 URI |
040 | a (SwePub)lud (SwePub)kid (SwePub)umu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a art2 swepub-publicationtype |
072 | 7 | a ref2 swepub-contenttype |
100 | 1 | a Campa, Daniele4 aut |
245 | 1 0 | a Leukocyte telomere length in relation to pancreatic cancer risk: a prospective study. |
264 | 1 | c 2014 |
520 | a Background: Several studies have examined leukocyte telomere length (LTL) as a possible predictor for cancer at various organ sites. The hypothesis originally motivating many of these studies was that shorter telomeres would be associated with an increase in cancer risk, the results of epidemiologic studies have been inconsistent, however, and suggested positive, negative, or null associations. Two studies have addressed the association of LTL in relation to pancreatic cancer risk and the results are contrasting. Methods: we measured LTL in a prospective study of 331 pancreatic cancer cases and 331 controls in the context of the European Prospective Investigation into Cancer and Nutrition (EPIC). Results: We observed that the mean LTL was higher in cases (0.59±0.20) than in controls (0.57±0.17), although this difference was not statistically significant (p=0.07), and a basic logistic regression model showed no association of LTL with pancreas cancer risk. When adjusting for levels of HbA1c and C-Peptide, however, there was a weakly positive association between longer LTL and pancreatic cancer risk , OR=1.13 (1.01-1.27). Additional analyses by cubic spline regression suggested a possible non-linear relationship between RTL and pancreatic cancer risk (P=0.022), with a statistically non-significant increase in risk at very low LTL, as well as a significant increase at high LTL. Conclusion: Taken together, the results from our study do not support LTL as a uniform and strong predictor of pancreatic cancer. Impact: The results of this manuscript can provide insights into telomere dynamics and highlight the complex relationship between LTL and pancreatic cancer risk. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng |
700 | 1 | a Mergarten, Björn4 aut |
700 | 1 | a De Vivo, Immaculata4 aut |
700 | 1 | a Boutron-Ruault, Marie-Christine4 aut |
700 | 1 | a Racine, Antoine4 aut |
700 | 1 | a Severi, Gianluca4 aut |
700 | 1 | a Nieters, Alexandra4 aut |
700 | 1 | a Katzke, Verena A4 aut |
700 | 1 | a Trichopoulou, Antonia4 aut |
700 | 1 | a Yiannakouris, Nikos4 aut |
700 | 1 | a Trichopoulos, Dimitrios4 aut |
700 | 1 | a Boeing, Heiner4 aut |
700 | 1 | a Quiros, J Ramon4 aut |
700 | 1 | a Duell, Eric J4 aut |
700 | 1 | a Molina-Montes, Esther4 aut |
700 | 1 | a Huerta, Jose-Maria4 aut |
700 | 1 | a Ardanaz, Eva4 aut |
700 | 1 | a Dorronsoro, Miren4 aut |
700 | 1 | a Khaw, Kay-Tee4 aut |
700 | 1 | a Wareham, Nick4 aut |
700 | 1 | a Travis, Ruth C4 aut |
700 | 1 | a Palli, Domenico4 aut |
700 | 1 | a Pala, Valeria4 aut |
700 | 1 | a Tumino, Rosario4 aut |
700 | 1 | a Naccarati, Alessio4 aut |
700 | 1 | a Panico, Salvatore4 aut |
700 | 1 | a Vineis, Paolo4 aut |
700 | 1 | a Riboli, Elio4 aut |
700 | 1 | a Siddiq, Afshan4 aut |
700 | 1 | a Bueno-de-Mesquita, H B4 aut |
700 | 1 | a Peeters, Petra H M4 aut |
700 | 1 | a Nilsson, Peteru Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups4 aut0 (Swepub:lu)medf-pni |
700 | 1 | a Sund, Malin,d 1972-u Umeå universitet,Kirurgi4 aut0 (Swepub:umu)masu0021 |
700 | 1 | a Ye, Weiminu Umeå universitet,Karolinska Institutet,Enheten för biobanksforskning,Karolinska Inst, Dept Med Epidemiol & Biostat4 aut |
700 | 1 | a Lund, Eiliv4 aut |
700 | 1 | a Jareid, Mie4 aut |
700 | 1 | a Weiderpass, Elisabeteu Karolinska Institutet4 aut |
700 | 1 | a Duarte-Salles, Talita4 aut |
700 | 1 | a Kong, So Y4 aut |
700 | 1 | a Stepien, Magdalena4 aut |
700 | 1 | a Canzian, Federico4 aut |
700 | 1 | a Kaaks, Rudolf4 aut |
700 | 1 | a Wareham, Nicholas4 aut |
710 | 2 | a Internmedicin - epidemiologib Forskargrupper vid Lunds universitet4 org |
773 | 0 | t Cancer Epidemiology Biomarkers & Preventiong 23:11, s. 2447-2454q 23:11<2447-2454x 1538-7755x 1055-9965 |
856 | 4 | u http://www.ncbi.nlm.nih.gov/pubmed/25103821?dopt=Abstracty FULLTEXT |
856 | 4 | u http://dx.doi.org/10.1158/1055-9965.EPI-14-0247y FULLTEXT |
856 | 4 8 | u https://lup.lub.lu.se/record/4615383 |
856 | 4 8 | u https://doi.org/10.1158/1055-9965.EPI-14-0247 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:130135318 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-97595 |
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