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Heart rate and adve...
Heart rate and adverse outcomes in patients with prevalent atrial fibrillation
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- Moschovitis, Giorgio (author)
- Regional Hospital of Lugano
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- Johnson, Linda S B (author)
- Lund University,Lunds universitet,Kardiovaskulär forskning - epidemiologi,Forskargrupper vid Lunds universitet,Internmedicin - epidemiologi,Cardiovascular Research - Epidemiology,Lund University Research Groups,Internal Medicine - Epidemiology,McMaster University
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- Blum, Steffen (author)
- University Hospital Basel
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- Aeschbacher, Stefanie (author)
- University Hospital Basel
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- De Perna, Maria Luisa (author)
- Regional Hospital of Lugano
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Pagnamenta, Alberto (author)
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- Mayer Melchiorre, Patrizia Assunta (author)
- Regional Hospital of Lugano
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- Benz, Alexander P (author)
- McMaster University
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- Kobza, Richard (author)
- Cantonal Hospital Lucerne
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- Di Valentino, Marcello (author)
- Università della Svizzera Italiana
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- Zuern, Christine S (author)
- University Hospital Basel
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- Auricchio, Angelo (author)
- Cardiocentro Ticino Foundation
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Conte, Giulio (author)
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- Rodondi, Nicolas (author)
- Bern University Hospital
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- Blum, Manuel R (author)
- Bern University Hospital
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- Beer, Juerg H (author)
- Hospital Baden
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- Kühne, Michael (author)
- University Hospital Basel
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- Osswald, Stefan (author)
- University Hospital Basel
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- Conen, David (author)
- McMaster University
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(creator_code:org_t)
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- 2021-04-21
- 2021
- English.
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In: Open Heart. - : BMJ. - 2053-3624. ; 8:1
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Abstract
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- OBJECTIVE: The optimal target heart rate in patients with prevalent atrial fibrillation (AF) is not well defined. The aim of this study was to analyse the associations between heart rate and adverse outcomes in a large contemporary cohort of patients with prevalent AF.METHODS: From two prospective cohort studies, we included stable AF outpatients who were in AF on the baseline ECG. The main outcome events assessed during prospective follow-up were heart failure hospitalisation, stroke or systemic embolism and death. The associations between heart rate and adverse outcomes were evaluated using multivariable Cox regression models.RESULTS: The study population consisted of 1679 patients who had prevalent AF at baseline. Mean age was 74 years, and 24.6% were women. The mean heart rate on the baseline ECG was 78 (±19) beats per minute (bpm). The median follow-up was 3.9 years (IQR 2.2-5.0). Heart rate was not significantly associated with heart failure hospitalisation (adjusted HR (aHR) per 10 bpm increase, 1.00, 95% CI 0.94 to 1.07, p=0.95), stroke or systemic embolism (aHR 0.95, 95% CI 0.84 to 1.07, p=0.38) or death (aHR 1.02, 95% CI 0.95 to 1.09, p=0.66). There was no evidence of a threshold effect for heart rates <60 bpm or >100 bpm.CONCLUSIONS: In this large contemporary cohort of outpatients with prevalent AF, we found no association between heart rate and adverse outcome events. These data are in line with recommendations that strict heart rate control is not needed in otherwise stable outpatients with AF.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
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- art (subject category)
- ref (subject category)
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Open Heart
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Moschovitis, Gio ...
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Johnson, Linda S ...
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Blum, Steffen
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Aeschbacher, Ste ...
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De Perna, Maria ...
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Pagnamenta, Albe ...
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Mayer Melchiorre ...
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Benz, Alexander ...
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Kobza, Richard
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Di Valentino, Ma ...
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Zuern, Christine ...
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Auricchio, Angel ...
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Conte, Giulio
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Rodondi, Nicolas
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Blum, Manuel R
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Beer, Juerg H
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Kühne, Michael
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Osswald, Stefan
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Conen, David
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show less...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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Open Heart
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Lund University