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Microglia-Secreted ...
Microglia-Secreted Galectin-3 Acts as a Toll-like Receptor 4 Ligand and Contributes to Microglial Activation.
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- Burguillos Garcia, Miguel (author)
- Lund University,Lunds universitet,Institutionen för experimentell medicinsk vetenskap,Medicinska fakulteten,Department of Experimental Medical Science,Faculty of Medicine
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- Svensson, Martina (author)
- Lund University,Lunds universitet,Institutionen för experimentell medicinsk vetenskap,Medicinska fakulteten,Neuroinflammation,Forskargrupper vid Lunds universitet,Department of Experimental Medical Science,Faculty of Medicine,Lund University Research Groups
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- Schulte, Tim (author)
- Karolinska Institutet
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- Boza Serrano, Antonio (author)
- Lund University,Lunds universitet,Neuroinflammation,Forskargrupper vid Lunds universitet,Lund University Research Groups
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Garcia-Quintanilla, Albert (author)
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Kavanagh, Edel (author)
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Santiago, Martiniano (author)
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Viceconte, Nikenza (author)
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Oliva-Martin, Maria Jose (author)
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- Osman, Ahmed Mohamed (author)
- Karolinska Institutet
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- Salomonsson, Emma (author)
- Lund University,Lunds universitet,Avdelningen för mikrobiologi, immunologi och glykobiologi - MIG,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Microbiology, Immunology and Glycobiology - MIG,Department of Laboratory Medicine,Faculty of Medicine
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- Amar, Lahouari (author)
- Lund University,Lunds universitet,Institutionen för experimentell medicinsk vetenskap,Medicinska fakulteten,Department of Experimental Medical Science,Faculty of Medicine
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- Persson, Annette (author)
- Lund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Blomgren, Klas (author)
- Karolinska Institutet
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- Achour, Adnane (author)
- Karolinska Institutet
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- Englund, Elisabet (author)
- Lund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Leffler, Hakon (author)
- Lund University,Lunds universitet,Avdelningen för mikrobiologi, immunologi och glykobiologi - MIG,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Microbiology, Immunology and Glycobiology - MIG,Department of Laboratory Medicine,Faculty of Medicine
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Venero, Jose Luis (author)
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- Joseph, Bertrand (author)
- Karolinska Institutet
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- Deierborg, Tomas (author)
- Lund University,Lunds universitet,Institutionen för experimentell medicinsk vetenskap,Medicinska fakulteten,Neuroinflammation,Forskargrupper vid Lunds universitet,Department of Experimental Medical Science,Faculty of Medicine,Lund University Research Groups
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(creator_code:org_t)
- Elsevier BV, 2015
- 2015
- English.
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In: Cell Reports. - : Elsevier BV. - 2211-1247. ; 10:9, s. 1626-1638
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Abstract
Subject headings
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- Inflammatory response induced by microglia plays a critical role in the demise of neuronal populations in neuroinflammatory diseases. Although the role of toll-like receptor 4 (TLR4) in microglia's inflammatory response is fully acknowledged, little is known about endogenous ligands that trigger TLR4 activation. Here, we report that galectin-3 (Gal3) released by microglia acts as an endogenous paracrine TLR4 ligand. Gal3-TLR4 interaction was further confirmed in a murine neuroinflammatory model (intranigral lipopolysaccharide [LPS] injection) and in human stroke subjects. Depletion of Gal3 exerted neuroprotective and anti-inflammatory effects following global brain ischemia and in the neuroinflammatory LPS model. These results suggest that Gal3-dependent-TLR4 activation could contribute to sustained microglia activation, prolonging the inflammatory response in the brain.
Subject headings
- NATURVETENSKAP -- Biologi -- Cellbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Cell Biology (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
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To the university's database
- By the author/editor
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Burguillos Garci ...
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Svensson, Martin ...
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Schulte, Tim
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Boza Serrano, An ...
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Garcia-Quintanil ...
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Kavanagh, Edel
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show more...
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Santiago, Martin ...
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Viceconte, Niken ...
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Oliva-Martin, Ma ...
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Osman, Ahmed Moh ...
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Salomonsson, Emm ...
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Amar, Lahouari
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Persson, Annette
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Blomgren, Klas
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Achour, Adnane
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Englund, Elisabe ...
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Leffler, Hakon
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Venero, Jose Lui ...
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Joseph, Bertrand
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Deierborg, Tomas
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show less...
- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Cell Biology
- Articles in the publication
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Cell Reports
- By the university
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Lund University
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Karolinska Institutet