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The Relationships between Sex Hormones and Sexual Function in Middle-Aged and Older European Men.
- O'Connor, Daryl B (author)
- Lee, David M (author)
- Corona, Giovanni (author)
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- Forti, Gianni (author)
- Tajar, Abdelouahid (author)
- O'Neill, Terence W (author)
- Pendleton, Neil (author)
- Bartfai, Gyorgy (author)
- Boonen, Steven (author)
- Casanueva, Felipe F (author)
- Finn, Joseph D (author)
- Han, Thang S (author)
- Huhtaniemi, Ilpo T (author)
- Kula, Krzysztof (author)
- Labrie, Fernand (author)
- Lean, Michael E J (author)
- Punab, Margus (author)
- Silman, Alan J (author)
- Vanderschueren, Dirk (author)
- Wu, Frederick C W (author)
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- (creator_code:org_t)
- The Endocrine Society, 2011
- 2011
- English.
- In: The Journal of clinical endocrinology and metabolism. - : The Endocrine Society. - 1945-7197 .- 0021-972X. ; 96, s. 1577-1587
- Journal article (peer-reviewed)
Abstract
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- Context: Limited data are available exploring the associations between sex hormones, multiple domains of sexual functioning, and sexual function-related distress in nonpatient samples in Europe. Objectives: The aim of the study was to investigate the relationships between serum testosterone (T), estradiol (E2), and dihydrotestosterone (DHT) and sexual function in a multicenter population-based study of aging in men. Design: Using stratified random sampling, 2838 men aged 40-79 yr completed the European Male Ageing Study-Sexual Function Questionnaire and provided a blood sample for hormone measurements. T, E2, and DHT were measured using gas chromatography-mass spectrometry. Setting: We conducted a community-based population survey in eight European centers. Main Outcome Measures: Self-reported sexual function (overall sexual function, sexual function-related distress, erectile dysfunction, masturbation) was measured. Results: Total and free T, but not E2 or DHT, was associated with overall sexual function in middle-aged and older men. E2 was the only hormone associated with sexual function-related distress such that higher levels were related to greater distress. Free T levels were associated with masturbation frequency and erectile dysfunction in the fully adjusted models, such that higher T was associated with less dysfunction and greater frequency. Moreover, there was a T threshold for the relationship between total T, sexual function, and erectile dysfunction. At T concentrations of 8 nmol/liter or less, T was associated with worse sexual functioning, whereas at T levels over 8 nmol/liter, the relationship came to a plateau. Conclusions: These findings suggest that different hormonal mechanisms may regulate sexual functioning (T) vs. the psychological aspects (E2) of male sexual behavior. Moreover, there was a T threshold for overall sexual function such that at levels greater than 8 nmol/liter the relationship between T and sexual function did not become stronger.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
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- Lee, David M
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- Pendleton, Neil
- Bartfai, Gyorgy
- Boonen, Steven
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- Han, Thang S
- Huhtaniemi, Ilpo ...
- Kula, Krzysztof
- Labrie, Fernand
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- Punab, Margus
- Silman, Alan J
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