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  • O'Connor, Daryl B (author)

The Relationships between Sex Hormones and Sexual Function in Middle-Aged and Older European Men.

  • Article/chapterEnglish2011

Publisher, publication year, extent ...

  • The Endocrine Society,2011

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  • LIBRIS-ID:oai:lup.lub.lu.se:d436dc6e-dbdc-44a4-8364-efdedd1b4dce
  • https://lup.lub.lu.se/record/2150921URI
  • https://doi.org/10.1210/jc.2010-2216DOI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Context: Limited data are available exploring the associations between sex hormones, multiple domains of sexual functioning, and sexual function-related distress in nonpatient samples in Europe. Objectives: The aim of the study was to investigate the relationships between serum testosterone (T), estradiol (E2), and dihydrotestosterone (DHT) and sexual function in a multicenter population-based study of aging in men. Design: Using stratified random sampling, 2838 men aged 40-79 yr completed the European Male Ageing Study-Sexual Function Questionnaire and provided a blood sample for hormone measurements. T, E2, and DHT were measured using gas chromatography-mass spectrometry. Setting: We conducted a community-based population survey in eight European centers. Main Outcome Measures: Self-reported sexual function (overall sexual function, sexual function-related distress, erectile dysfunction, masturbation) was measured. Results: Total and free T, but not E2 or DHT, was associated with overall sexual function in middle-aged and older men. E2 was the only hormone associated with sexual function-related distress such that higher levels were related to greater distress. Free T levels were associated with masturbation frequency and erectile dysfunction in the fully adjusted models, such that higher T was associated with less dysfunction and greater frequency. Moreover, there was a T threshold for the relationship between total T, sexual function, and erectile dysfunction. At T concentrations of 8 nmol/liter or less, T was associated with worse sexual functioning, whereas at T levels over 8 nmol/liter, the relationship came to a plateau. Conclusions: These findings suggest that different hormonal mechanisms may regulate sexual functioning (T) vs. the psychological aspects (E2) of male sexual behavior. Moreover, there was a T threshold for overall sexual function such that at levels greater than 8 nmol/liter the relationship between T and sexual function did not become stronger.

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Added entries (persons, corporate bodies, meetings, titles ...)

  • Lee, David M (author)
  • Corona, Giovanni (author)
  • Forti, Gianni (author)
  • Tajar, Abdelouahid (author)
  • O'Neill, Terence W (author)
  • Pendleton, Neil (author)
  • Bartfai, Gyorgy (author)
  • Boonen, Steven (author)
  • Casanueva, Felipe F (author)
  • Finn, Joseph D (author)
  • Giwercman, AleksanderLund University,Lunds universitet,Institutionen för translationell medicin,Medicinska fakulteten,Department of Translational Medicine,Faculty of Medicine(Swepub:lu)kir-agi (author)
  • Han, Thang S (author)
  • Huhtaniemi, Ilpo T (author)
  • Kula, Krzysztof (author)
  • Labrie, Fernand (author)
  • Lean, Michael E J (author)
  • Punab, Margus (author)
  • Silman, Alan J (author)
  • Vanderschueren, Dirk (author)
  • Wu, Frederick C W (author)
  • Institutionen för translationell medicinMedicinska fakulteten (creator_code:org_t)

Related titles

  • In:The Journal of clinical endocrinology and metabolism: The Endocrine Society96, s. 1577-15871945-71970021-972X

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