Search: onr:"swepub:oai:lup.lub.lu.se:d4a847df-2957-40fc-ad4a-d9c751d6e20d" > Predicting Islet Ce...
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000 | 11074naa a2200817 4500 | |
001 | oai:lup.lub.lu.se:d4a847df-2957-40fc-ad4a-d9c751d6e20d | |
003 | SwePub | |
008 | 190625s2019 | |||||||||||000 ||eng| | |
024 | 7 | a https://lup.lub.lu.se/record/d4a847df-2957-40fc-ad4a-d9c751d6e20d2 URI |
024 | 7 | a https://doi.org/10.2337/dc18-22822 DOI |
040 | a (SwePub)lu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a art2 swepub-publicationtype |
072 | 7 | a ref2 swepub-contenttype |
100 | 1 | a Krischer, Jeffrey Pu University of South Florida4 aut |
245 | 1 0 | a Predicting Islet Cell Autoimmunity and Type 1 Diabetes : An 8-Year TEDDY Study Progress Report |
264 | c 2019-04-09 | |
264 | 1 | b American Diabetes Association,c 2019 |
300 | a 10 s. | |
520 | a OBJECTIVE: Assessment of the predictive power of The Environmental Determinants of Diabetes in the Young (TEDDY)-identified risk factors for islet autoimmunity (IA), the type of autoantibody appearing first, and type 1 diabetes (T1D).RESEARCH DESIGN AND METHODS: A total of 7,777 children were followed from birth to a median of 9.1 years of age for the development of islet autoantibodies and progression to T1D. Time-dependent sensitivity, specificity, and receiver operating characteristic (ROC) curves were calculated to provide estimates of their individual and collective ability to predict IA and T1D.RESULTS: HLA genotype (DR3/4 vs. others) was the best predictor for IA (Youden's index J = 0.117) and single nucleotide polymorphism rs2476601, in PTPN22, was the best predictor for insulin autoantibodies (IAA) appearing first (IAA-first) (J = 0.123). For GAD autoantibodies (GADA)-first, weight at 1 year was the best predictor (J = 0.114). In a multivariate model, the area under the ROC curve (AUC) was 0.678 (95% CI 0.655, 0.701), 0.707 (95% CI 0.676, 0.739), and 0.686 (95% CI 0.651, 0.722) for IA, IAA-first, and GADA-first, respectively, at 6 years. The AUC of the prediction model for T1D at 3 years after the appearance of multiple autoantibodies reached 0.706 (95% CI 0.649, 0.762).CONCLUSIONS: Prediction modeling statistics are valuable tools, when applied in a time-until-event setting, to evaluate the ability of risk factors to discriminate between those who will and those who will not get disease. Although significantly associated with IA and T1D, the TEDDY risk factors individually contribute little to prediction. However, in combination, these factors increased IA and T1D prediction substantially. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng |
700 | 1 | a Liu, Xiangu University of South Florida4 aut |
700 | 1 | a Vehik, Kendrau University of South Florida4 aut0 (Swepub:lu)med-krv |
700 | 1 | a Akolkar, Beenau National Institute of Diabetes and Digestive and Kidney Diseases4 aut |
700 | 1 | a Hagopian, William Au Pacific Northwest Research Institute4 aut |
700 | 1 | a Rewers, Marian Ju University of Colorado4 aut |
700 | 1 | a She, Jin-Xiongu Medical College of Georgia4 aut |
700 | 1 | a Toppari, Jormau University of Turku,Turku University Hospital4 aut |
700 | 1 | a Ziegler, Anette-Gu Technical University of Munich4 aut |
700 | 1 | a Lernmark, Åkeu Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)endo-ale |
700 | 1 | a Agardh, Danielu Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups4 cre0 (Swepub:lu)med-dia |
700 | 1 | a Andrén Aronsson, Carinu Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups4 cre0 (Swepub:lu)smi-can |
700 | 1 | a Ask, Mariau Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups4 cre0 (Swepub:lu)med-ma1 |
700 | 1 | a Bremer, Jennyu Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups4 cre0 (Swepub:lu)med-jb1 |
700 | 1 | a Ericson-Hallström, Emelieu Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups4 cre0 (Swepub:lu)med-eeh |
700 | 1 | a Björne Fors, Annikau Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups4 cre0 (Swepub:lu)an6061fo |
700 | 1 | a Fransson, Linau Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups4 cre0 (Swepub:lu)med-lfo |
700 | 1 | a Gard, Thomasu Lund University,Lunds universitet,Trafik och väg,Institutionen för teknik och samhälle,Institutioner vid LTH,Lunds Tekniska Högskola,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Transport and Roads,Department of Technology and Society,Departments at LTH,Faculty of Engineering, LTH,Celiac Disease and Diabetes Unit,Lund University Research Groups4 cre0 (Swepub:lu)med-tgd |
700 | 1 | a Bennet, Rasmusu Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups4 cre0 (Swepub:lu)med-ruh |
700 | 1 | a Hyberg, Susanneu Lund University4 cre |
700 | 1 | a Jisser, Hannau Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups4 cre0 (Swepub:lu)ha8738ji |
700 | 1 | a Johansen, Fredriku Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups4 cre0 (Swepub:lu)med-fej |
700 | 1 | a Jónsdóttir, Berglindu Lund University,Lunds universitet,Pediatrisk endokrinologi,Forskargrupper vid Lunds universitet,Paediatric Endocrinology,Lund University Research Groups4 cre0 (Swepub:lu)med-bij |
700 | 1 | a JOVIC, SILVIJAu Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups4 cre0 (Swepub:lu)si6457jo |
700 | 1 | a Elding Larsson, Helenau Lund University,Lunds universitet,Pediatrisk endokrinologi,Forskargrupper vid Lunds universitet,Paediatric Endocrinology,Lund University Research Groups4 cre0 (Swepub:lu)pedi-hla |
700 | 1 | a Lindström, Marielleu Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups4 cre0 (Swepub:lu)ma4567li |
700 | 1 | a Lundgren, Markusu Lund University,Lunds universitet,Pediatrisk endokrinologi,Forskargrupper vid Lunds universitet,Paediatric Endocrinology,Lund University Research Groups4 cre0 (Swepub:lu)med-mn2 |
700 | 1 | a Månsson Martinez, Mariau Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups4 cre0 (Swepub:lu)med-mem |
700 | 1 | a Markan, Mariau Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups4 cre0 (Swepub:lu)med-mam |
700 | 1 | a Melin, Marie Jessicau Lund University,Lunds universitet,Pediatrisk endokrinologi,Forskargrupper vid Lunds universitet,Paediatric Endocrinology,Lund University Research Groups4 cre0 (Swepub:lu)med-jim |
700 | 1 | a Mestan, Zelihau Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups4 cre0 (Swepub:lu)med-zam |
700 | 1 | a Nilsson, Caroline Nu Lund University,Lunds universitet,Pediatrisk endokrinologi,Forskargrupper vid Lunds universitet,Paediatric Endocrinology,Lund University Research Groups4 cre0 (Swepub:lu)med-nsc |
700 | 1 | a Ottosson, Karinu Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups4 cre0 (Swepub:lu)ka8334ot |
700 | 1 | a Rahmati, Kobrau Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups4 cre0 (Swepub:lu)med-krh |
700 | 1 | a Ramelius, Anitau Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups4 cre0 (Swepub:lu)endo-ani |
700 | 1 | a Salami, Falastinu Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups4 cre0 (Swepub:lu)med-fss |
700 | 1 | a Sjöberg, Anetteu Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups4 cre0 (Swepub:lu)an0502sj |
700 | 1 | a Sjöberg, Birgittau Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups4 cre0 (Swepub:lu)med-bsj |
700 | 1 | a Törn, Carinau Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups4 cre0 (Swepub:lu)med-cto |
700 | 1 | a Wallin, Anneu Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups4 cre0 (Swepub:lu)med-anw |
700 | 1 | a Wimar, Åsau Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups4 cre0 (Swepub:lu)med-awi |
700 | 1 | a Åberg, Sofieu Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups4 cre0 (Swepub:lu)med-sae |
710 | 2 | a University of South Floridab National Institute of Diabetes and Digestive and Kidney Diseases4 org |
710 | 2 | a TEDDY Study Group |
773 | 0 | t Diabetes Cared : American Diabetes Associationg 42:6, s. 1051-1060q 42:6<1051-1060x 1935-5548x 0149-5992 |
856 | 4 | u http://dx.doi.org/10.2337/dc18-2282y FULLTEXT |
856 | 4 | u https://care.diabetesjournals.org/content/diacare/42/6/1051.full.pdf |
856 | 4 8 | u https://lup.lub.lu.se/record/d4a847df-2957-40fc-ad4a-d9c751d6e20d |
856 | 4 8 | u https://doi.org/10.2337/dc18-2282 |
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