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A Head-to-Head Comp...
A Head-to-Head Comparison Between Plasma pTau181 and Tau PET Along the Alzheimer’s Disease Continuum
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- Coomans, Emma M. (author)
- Vrije Universiteit Amsterdam
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- Verberk, Inge M.W. (author)
- Vrije Universiteit Amsterdam
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- Ossenkoppele, Rik (author)
- Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,LU profilområde: Proaktivt åldrande,Lunds universitets profilområden,Clinical Memory Research,Lund University Research Groups,LU Profile Area: Proactive Ageing,Lund University Profile areas,Amsterdam UMC - Vrije Universiteit Amsterdam,Vrije Universiteit Amsterdam
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- Verfaillie, Sander C.J. (author)
- University of Amsterdam,Vrije Universiteit Amsterdam
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- Visser, Denise (author)
- Vrije Universiteit Amsterdam
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- Gouda, Mariam (author)
- Vrije Universiteit Amsterdam
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- Tuncel, Hayel (author)
- Vrije Universiteit Amsterdam
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- Wolters, Emma E. (author)
- Vrije Universiteit Amsterdam
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- Timmers, Tessa (author)
- Vrije Universiteit Amsterdam
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- Windhorst, Albert D. (author)
- Vrije Universiteit Amsterdam
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- Golla, Sandeep S.V. (author)
- Vrije Universiteit Amsterdam
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- Scheltens, Philip (author)
- Vrije Universiteit Amsterdam
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- van der Flier, Wiesje M. (author)
- Vrije Universiteit Amsterdam
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- van Berckel, Bart N.M. (author)
- Vrije Universiteit Amsterdam
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- Teunissen, Charlotte E. (author)
- Vrije Universiteit Amsterdam
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(creator_code:org_t)
- 2022-10-13
- 2023
- English 7 s.
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In: Journal of Nuclear Medicine. - : Society of Nuclear Medicine. - 0161-5505 .- 2159-662X. ; 64:3, s. 437-443
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Abstract
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- Both plasma tau phosphorylated at threonine-181 (pTau181) and tau PET show potential for detecting Alzheimer’s disease (AD) pathology and predicting clinical progression. In this study, we performed a head-to-head comparison between plasma pTau181 and tau PET along the AD continuum. Methods: We included participants from the Amsterdam Dementia Cohort who underwent 18F-flortaucipir (tau) PET and had a plasma sample biobanked within 12 mo from tau PET. Fifty subjective cognitive decline (SCD) participants (31 Ab-negative and 19 Ab-positive) and 60 Ab-positive participants with mild cognitive impairment (MCI) or dementia due to AD were included. A subset had 2-y longitudinal plasma pTau181 and tau PET available (n 5 40). Longitudinal neuropsychological test data covering 3.2 6 2.7 y from both before and after tau PET were available. Plasma pTau181 and tau PET were compared in their accuracies in discriminating between cognitive stage (MCI/AD vs. SCD) and preclinical Ab status (SCD Ab-positive vs. SCD Ab-negative), their associations with cross-sectional and longitudinal neuropsychological test performance, and their longitudinal changes over time. Results: When discriminating between preclinical Ab status, the area under the curve (AUC) for plasma pTau181 (0.83) and tau PET (entorhinal, 0.87; temporal, 0.85; neocortical, 0.67) were equally high (all DeLong P . 0.05), but tau PET outperformed plasma pTau181 in discriminating MCI/AD from SCD (AUC for plasma pTau181: 0.74; AUCs for tau PET: entorhinal, 0.89; temporal, 0.92; neocortical, 0.89) (all P, 0.01). Overall, tau PET showed stronger associations with cognitive decline and was associated with a wider variety of cognitive tests than plasma pTau181 (plasma pTau181, 20.02 . b, 20.12; tau PET, 20.01 . b, 20.22). Both plasma pTau181 and tau PET increased more steeply over time in MCI/AD than in SCD (P, 0.05), but only tau PET annual changes were associated with cognitive decline. Conclusion: Our results suggest that plasma pTau181 and tau PET perform equally well in identifying Ab pathology but that tau PET better monitors disease stage and clinical progression.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- Alzheimer’s disease
- plasma pTau181
- tau PET
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Coomans, Emma M.
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Verberk, Inge M. ...
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Ossenkoppele, Ri ...
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Verfaillie, Sand ...
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Visser, Denise
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Gouda, Mariam
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Tuncel, Hayel
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Wolters, Emma E.
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Timmers, Tessa
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Windhorst, Alber ...
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Golla, Sandeep S ...
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Scheltens, Phili ...
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van der Flier, W ...
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van Berckel, Bar ...
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Teunissen, Charl ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
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Journal of Nucle ...
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Lund University