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Motor associations ...
Motor associations of iron accumulation in deep grey matter nuclei in Parkinson's disease : A cross-sectional study of iron-related magnetic resonance imaging susceptibility
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- Martin-Bastida, A. (author)
- Imperial College London
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- Lao-Kaim, N. P. (author)
- Imperial College London
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- Loane, C. (author)
- University of Oxford
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- Politis, M. (author)
- King's College London
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- Roussakis, A. A. (author)
- Imperial College London
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- Valle-Guzman, N. (author)
- University of Cambridge
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- Kefalopoulou, Z. (author)
- Royal Free Hospital
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- Paul-Visse, G. (author)
- Lund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Widner, H. (author)
- Lund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital
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- Xing, Y. (author)
- Queen's Medical Centre, Nottingham
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- Schwarz, S. T. (author)
- Queen's Medical Centre, Nottingham
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- Auer, D. P. (author)
- Queen's Medical Centre, Nottingham
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- Foltynie, T. (author)
- Royal Free Hospital
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- Barker, R. A. (author)
- University of Cambridge
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- Piccini, P. (author)
- Imperial College London
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(creator_code:org_t)
- 2016-12-16
- 2017
- English.
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In: European Journal of Neurology. - : Wiley. - 1351-5101. ; 24:2, s. 357-365
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Abstract
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- Background and purpose: To determine whether iron deposition in deep brain nuclei assessed using high-pass filtered phase imaging plays a role in motor disease severity in Parkinson's disease (PD). Methods: Seventy patients with mild to moderate PD and 20 age- and gender-matched healthy volunteers (HVs) underwent susceptibility-weighted imaging on a 3 T magnetic resonance imaging scanner. Phase shifts (radians) in deep brain nuclei were derived from high-pass filtered phase images and compared between groups. Analysis of clinical laterality and correlations with motor severity (Unified Parkinson's Disease Rating Scale, Part III, UPDRS-III) were performed. Phase shifts (in radians) were compared between HVs and three PD subgroups divided according to UPDRS-III scores using analysis of covariance, adjusting for age and regional area. Results: Parkinson's disease patients had significantly (P < 0.001) higher radians than HVs bilaterally in the putamen, globus pallidus and substantia nigra (SN). The SN contralateral to the most affected side showed higher radians (P < 0.001) compared to the less affected side. SN radians positively correlated with UPDRS-III and bradykinesia-rigidity subscores, but not with tremor subscores. ancova followed by post hoc Bonferroni-adjusted pairwise comparisons revealed that SN radians were significantly greater in the PD subgroup with higher UPDRS-III scores compared to both lowest UPDRS-III PD and HV groups (P < 0.001). Conclusions: Increased nigral iron accumulation in PD appears to be stratified according to disease motor severity and correlates with symptoms related to dopaminergic neurodegeneration. This semi-quantitative in vivo iron assessment could prove useful for objectively monitoring PD progression, especially in clinical trials concerning iron chelation therapies.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- Iron
- Motor severity
- Neurodegeneration
- Parkinson's disease
- SWI
Publication and Content Type
- art (subject category)
- ref (subject category)
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Martin-Bastida, ...
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Lao-Kaim, N. P.
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Loane, C.
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Politis, M.
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Roussakis, A. A.
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Valle-Guzman, N.
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show more...
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Kefalopoulou, Z.
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Paul-Visse, G.
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Widner, H.
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Xing, Y.
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Schwarz, S. T.
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Auer, D. P.
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Foltynie, T.
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Barker, R. A.
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Piccini, P.
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Lund University