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Gene Profiling of H...
Gene Profiling of Human Induced Pluripotent Stem Cell-Derived Astrocyte Progenitors Following Spinal Cord Engraftment.
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Haidet-Phillips, Amanda M (author)
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- Roybon, Laurent (author)
- Lund University,Lunds universitet,Stamcellslaboratoriet för sjukdomsmodellering i det centrala nervsystemet,Forskargrupper vid Lunds universitet,IPSC Laboratory for CNS Disease Modeling,Lund University Research Groups
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Gross, Sarah K (author)
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Tuteja, Alisha (author)
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Donnelly, Christopher J (author)
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Richard, Jean-Philippe (author)
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Ko, Myungsung (author)
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Sherman, Alex (author)
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Eggan, Kevin (author)
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Henderson, Christopher E (author)
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Maragakis, Nicholas J (author)
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(creator_code:org_t)
- 2014-03-06
- 2014
- English.
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In: Stem cells translational medicine. - : Oxford University Press (OUP). - 2157-6580 .- 2157-6564. ; 3:5, s. 575-585
- Related links:
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http://www.ncbi.nlm....
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http://dx.doi.org/10...
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https://doi.org/10.5...
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https://doi.org/10.5...
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Abstract
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- The generation of human induced pluripotent stem cells (hiPSCs) represents an exciting advancement with promise for stem cell transplantation therapies as well as for neurological disease modeling. Based on the emerging roles for astrocytes in neurological disorders, we investigated whether hiPSC-derived astrocyte progenitors could be engrafted to the rodent spinal cord and how the characteristics of these cells changed between in vitro culture and after transplantation to the in vivo spinal cord environment. Our results show that human embryonic stem cell- and hiPSC-derived astrocyte progenitors survive long-term after spinal cord engraftment and differentiate to astrocytes in vivo with few cells from other lineages present. Gene profiling of the transplanted cells demonstrates the astrocyte progenitors continue to mature in vivo and upregulate a variety of astrocyte-specific genes. Given this mature astrocyte gene profile, this work highlights hiPSCs as a tool to investigate disease-related astrocyte biology using in vivo disease modeling with significant implications for human neurological diseases currently lacking animal models.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
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- art (subject category)
- ref (subject category)
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- By the author/editor
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Haidet-Phillips, ...
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Roybon, Laurent
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Gross, Sarah K
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Tuteja, Alisha
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Donnelly, Christ ...
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Richard, Jean-Ph ...
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show more...
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Ko, Myungsung
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Sherman, Alex
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Eggan, Kevin
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Henderson, Chris ...
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Maragakis, Nicho ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Cell and Molecul ...
- Articles in the publication
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Stem cells trans ...
- By the university
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Lund University