Search: onr:"swepub:oai:lup.lub.lu.se:d51b7659-1421-4714-a3a5-d123c830f164" >
Fetal sex-specific ...
Abstract
Subject headings
Close
- Background: Pre-eclampsia (PE) is a major pregnancy disorder complicating up to 8% of pregnancies. Increasing evidence indicates a sex-specific interplay between the mother, placenta and fetus. This may lead to different adaptive mechanisms during pregnancy. Methods: We performed an individual participant data meta-analysis to determine associations of fetal sex and PE, with specific focus on gestational age at delivery in PE. This was done on 219 575 independent live-born singleton pregnancies, with a gestational age at birth between 22.0 and 43.0 weeks of gestation, from 11 studies participating in a worldwide consortium of international research groups focusing on pregnancy. Results: Of the women, 9033 (4.1%) experienced PE in their pregnancy and 48.8% of the fetuses were feMale versus 51.2% Male. No differences in the feMale/Male distribution were observed with respect to term PE (delivered > 37 weeks). Preterm PE (delivered < 37 weeks) was slightly more prevalent among pregnancies with a feMale fetus than in pregnancies with a Male fetus [odds ratio (OR) 1.11, 95% confidence interval (CI) 1.02-1.21]. Very preterm PE (delivered < 34 weeks) was even more prevalent among pregnancies with a feMale fetus as compared with pregnancies with a Male fetus (OR 1.36, 95% CI 1.17-1.59). Conclusions: Sexual dimorphic differences in the occurrence of PE exist, with preterm PE being more prevalent among pregnancies with a feMale fetus as compared with pregnancies with a Male fetus and with no differences with respect to term PE.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)
Keyword
- ALSPAC
- Placenta
- Pre-eclampsia
- Sex ratio
- Sexual dimorphism
Publication and Content Type
- art (subject category)
- ref (subject category)
Find in a library
To the university's database
- By the author/editor
-
Schalekamp-Timme ...
-
Arends, Lidia R.
-
Alsaker, Elin
-
Chappell, Lucy
-
Hansson, Stefan
-
Harsem, Nina K.
-
show more...
-
Jälmby, Maya
-
Jeyabalan, Arund ...
-
Laivuori, Hannel ...
-
Lawlor, Debbie A ...
-
Macdonald-Wallis ...
-
Magnus, Per
-
Myers, Jenny
-
Olsen, Jørn
-
Poston, Lucilla
-
Redman, Christop ...
-
Staff, Anne C.
-
Villa, Pia
-
Roberts, James M ...
-
Steegers, Eric A ...
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Obstetrics Gynae ...
- Articles in the publication
-
International Jo ...
- By the university
-
Lund University