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Establishment and I...
Establishment and Initial Experience of Clinical FLASH Radiotherapy in Canine Cancer Patients
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- Konradsson, Elise (author)
- Lund University,Lunds universitet,Medicinsk strålningsfysik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Radiotherapy Physics,Forskargrupper vid Lunds universitet,Medical Radiation Physics, Lund,Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups
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- Arendt, Maja L. (author)
- University of Copenhagen
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- Bastholm Jensen, Kristine (author)
- Veterinärhuset Öresund
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- Børresen, Betina (author)
- University of Copenhagen
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- Hansen, Anders E. (author)
- Technical University of Denmark
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- Bäck, Sven (author)
- Skåne University Hospital
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- Kristensen, Annemarie T. (author)
- University of Copenhagen
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- Munck af Rosenschöld, Per (author)
- Skåne University Hospital
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- Ceberg, Crister (author)
- Lund University,Lunds universitet,Medicinsk strålningsfysik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Radiotherapy Physics,Forskargrupper vid Lunds universitet,Rausinglaboratoriet i Lund - Tumörsektionen,Medical Radiation Physics, Lund,Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups,Rausing laboratory of Lund - Tumor section
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- Petersson, Kristoffer (author)
- University of Oxford,Skåne University Hospital
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(creator_code:org_t)
- 2021-05-13
- 2021
- English.
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In: Frontiers in Oncology. - : Frontiers Media SA. - 2234-943X. ; 11
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Abstract
Subject headings
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- FLASH radiotherapy has emerged as a treatment technique with great potential to increase the differential effect between normal tissue toxicity and tumor response compared to conventional radiotherapy. To evaluate the feasibility of FLASH radiotherapy in a relevant clinical setting, we have commenced a feasibility and safety study of FLASH radiotherapy in canine cancer patients with spontaneous superficial solid tumors or microscopic residual disease, using the electron beam of our modified clinical linear accelerator. The setup for FLASH radiotherapy was established using a short electron applicator with a nominal source-to-surface distance of 70 cm and custom-made Cerrobend blocks for collimation. The beam was characterized by measuring dose profiles and depth dose curves for various field sizes. Ten canine cancer patients were included in this initial study; seven patients with nine solid superficial tumors and three patients with microscopic disease. The administered dose ranged from 15 to 35 Gy. To ensure correct delivery of the prescribed dose, film measurements were performed prior to and during treatment, and a Farmer-type ion-chamber was used for monitoring. Treatments were found to be feasible, with partial response, complete response or stable disease recorded in 11/13 irradiated tumors. Adverse events observed at follow-up ranging from 3-6 months were mild and consisted of local alopecia, leukotricia, dry desquamation, mild erythema or swelling. One patient receiving a 35 Gy dose to the nasal planum, had a grade 3 skin adverse event. Dosimetric procedures, safety and an efficient clincal workflow for FLASH radiotherapy was established. The experience from this initial study will be used as a basis for a veterinary phase I/II clinical trial with more specific patient inclusion selection, and subsequently for human trials.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- NATURVETENSKAP -- Fysik -- Annan fysik (hsv//swe)
- NATURAL SCIENCES -- Physical Sciences -- Other Physics Topics (hsv//eng)
Keyword
- canine cancer patients
- dosimetry
- flash
- normal tissue
- radiation oncology
- radiotherapy
- ultra-high dose rate
Publication and Content Type
- art (subject category)
- ref (subject category)
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