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Chemerin Is an Anti...
Chemerin Is an Antimicrobial Agent in Human Epidermis
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Banas, Magdalena (author)
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Zabieglo, Katarzyna (author)
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- Kasetty, Gopinath (author)
- Lund University,Lunds universitet,Dermatologi och venereologi, Lund,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Dermatology and Venereology (Lund),Section III,Department of Clinical Sciences, Lund,Faculty of Medicine
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Kapinska-Mrowiecka, Monika (author)
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Borowczyk, Julia (author)
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Drukala, Justyna (author)
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Murzyn, Krzysztof (author)
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Zabel, Brian A. (author)
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Butcher, Eugene C. (author)
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Schroeder, Jens M. (author)
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- Schmidtchen, Artur (author)
- Lund University,Lunds universitet,Dermatologi och venereologi, Lund,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Dermatology and Venereology (Lund),Section III,Department of Clinical Sciences, Lund,Faculty of Medicine
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Cichy, Joanna (author)
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(creator_code:org_t)
- 2013-03-20
- 2013
- English.
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In: PLoS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 8:3
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Abstract
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- Chemerin, a chemoattractant ligand for chemokine-like receptor 1 (CMKLR1) is predicted to share similar tertiary structure with antibacterial cathelicidins. Recombinant chemerin has antimicrobial activity. Here we show that endogenous chemerin is abundant in human epidermis, and that inhibition of bacteria growth by exudates from organ cultures of primary human skin keratinocytes is largely chemerin-dependent. Using a panel of overlapping chemerin-derived synthetic peptides, we demonstrate that the antibacterial activity of chemerin is primarily mediated by Val 66 -Pro 85, which causes direct bacterial lysis. Therefore, chemerin is an antimicrobial agent in human skin.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Dermatologi och venereologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Dermatology and Venereal Diseases (hsv//eng)
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- ref (subject category)
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- By the author/editor
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Banas, Magdalena
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Zabieglo, Katarz ...
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Kasetty, Gopinat ...
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Kapinska-Mrowiec ...
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Borowczyk, Julia
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Drukala, Justyna
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show more...
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Murzyn, Krzyszto ...
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Zabel, Brian A.
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Butcher, Eugene ...
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Schroeder, Jens ...
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Schmidtchen, Art ...
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Cichy, Joanna
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Dermatology and ...
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PLoS ONE
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Lund University