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Effect of different...
Effect of different asthma treatments on risk of cold-related exacerbations
- Article/chapterEnglish2011
Publisher, publication year, extent ...
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2011-03-15
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European Respiratory Society (ERS),2011
Numbers
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LIBRIS-ID:oai:lup.lub.lu.se:d6acc34b-968d-43ce-8e39-993d8259460a
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https://lup.lub.lu.se/record/2187023URI
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https://doi.org/10.1183/09031936.00186510DOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:art swepub-publicationtype
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Subject category:ref swepub-contenttype
Notes
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Common colds often trigger asthma exacerbations. The present study compared cold-related severe exacerbations during budesonide/formoterol maintenance and reliever therapy, and different regimens of maintenance inhaled corticosteroids (ICS), with or without long-acting beta(2)-agonists (LABA), and with as-needed short-acting beta(2)-agonists (SABA) or LABA. Reported colds and severe exacerbations (defined by oral corticosteroid use and/or hospitalisation/emergency room visit) were assessed for 12,507 patients during 6-12 months of double-blind treatment. Exacerbations occurring <= 14 days after onset of reported colds were analysed by a Poisson model. The incidence of colds was similar across treatments. Asthma symptoms and reliever use increased during colds. Budesonide/formoterol maintenance and reliever therapy reduced severe cold-related exacerbations by 36% versus pooled comparators plus SABA (rate ratio (RR) 0.64; p=0.002), and for individual treatment comparisons, by 52% versus the same maintenance dose of ICS/LABA (RR 0.48; p < 0.001); there were nonsignificant reductions versus higher maintenance doses of ICS or ICS/LABA (RR 0.83 and 0.72, respectively). As-needed LABA did not reduce cold-related exacerbations versus as-needed SABA (RR 0.96). Severe cold-related exacerbations were reduced by budesonide/formoterol maintenance and reliever therapy compared with ICS with or without LABA and with as-needed SABA. Subanalyses suggested the importance of the ICS component in reducing cold-related exacerbations. Future studies should document the cause of exacerbations, in order to allow identification of different treatment effects.
Subject headings and genre
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Jenkins, C.
(author)
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Quirce, S.
(author)
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Sears, M. R.
(author)
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Bateman, E. D.
(author)
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O'Byrne, P. M.
(author)
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Humbert, M.
(author)
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Buhl, R.
(author)
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Harrison, T.
(author)
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Brusselle, G. G.
(author)
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Thoren, A.
(author)
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Sjobring, U.
(author)
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Peterson, S.
(author)
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Ostlund, O.
(author)
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Eriksson, GöranLund University,Lunds universitet,Lungmedicin, allergologi och palliativ medicin,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Respiratory Medicine, Allergology, and Palliative Medicine,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)med-geo
(author)
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Lungmedicin, allergologi och palliativ medicinSektion II
(creator_code:org_t)
Related titles
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In:European Respiratory Journal: European Respiratory Society (ERS)38:3, s. 584-5931399-30030903-1936
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- By the author/editor
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Reddel, H. K.
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Jenkins, C.
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Quirce, S.
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Sears, M. R.
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Bateman, E. D.
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O'Byrne, P. M.
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show more...
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Humbert, M.
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Buhl, R.
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Harrison, T.
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Brusselle, G. G.
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Thoren, A.
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Sjobring, U.
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Peterson, S.
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Ostlund, O.
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Eriksson, Göran
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- MEDICAL AND HEALTH SCIENCES
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European Respira ...
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Lund University