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Mesial temporal tau...
Mesial temporal tau is related to worse cognitive performance and greater neocortical tau load in amyloid-β–negative cognitively normal individuals
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- Groot, Colin (author)
- Vrije Universiteit Amsterdam,Amsterdam UMC - Vrije Universiteit Amsterdam
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- Doré, Vincent (author)
- Austin Health,CSIRO Health and Biosecurity
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- Robertson, Joanne (author)
- University of Melbourne
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- Burnham, Samantha C. (author)
- Edith Cowan University,CSIRO Health and Biosecurity
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- Savage, Greg (author)
- Macquarie University, Sydney
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- Ossenkoppele, Rik (author)
- Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Amsterdam UMC - Vrije Universiteit Amsterdam,Vrije Universiteit Amsterdam
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- Rowe, Christopher C. (author)
- Austin Health
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- Villemagne, Victor L. (author)
- Austin Health
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(creator_code:org_t)
- Elsevier BV, 2021
- 2021
- English 8 s.
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In: Neurobiology of Aging. - : Elsevier BV. - 0197-4580. ; 97, s. 41-48
- Related links:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Subject headings
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- We examined whether mesial temporal (Me) tau relates to cognitive performance in 47 amyloid-β (Aβ)-negative, cognitively normal older adults (>60 years old). Me-tau was measured using [18F]flortaucipir–positron emission tomography standardized uptake value ratio. The effect of continuous and categorical (stratified at standardized uptake value ratio = 1.2 [21% Me-positive]) Me-tau on cognition (mini-mental state examination, pre-Alzheimer's cognitive composite, a memory composite, and a nonmemory composite score) was examined using general linear models, and associations between Me-tau and [18F]flortaucipir signal in the neocortex were assessed using voxelwise regressions (continuous) and voxelwise contrasts (categorical). In addition, we assessed the effect of age and Aβ burden on Me-tau. Both continuous and categorical Me-tau was associated with worse cognitive performance across all tests and with higher lateral temporal and parietal [18F]flortaucipir signal. Furthermore, we observed a marginal association between Me-tau and age, whereas there was no association with Aβ burden. Our findings indicate that Me-tau in Aβ-negative cognitively normal individuals, which is likely age-related (i.e., primary age-related tauopathy), might not be as benign as commonly thought.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- Mesial temporal lobe
- PART
- PET
- Tau
Publication and Content Type
- art (subject category)
- ref (subject category)
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