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Lower Frequency of ...
Lower Frequency of Comorbidities Prior to Onset of Giant Cell Arteritis : A Population-Based Study
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- Elfishawi, Mohanad (author)
- Mayo Clinic Minnesota
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- Rakholiya, Jigisha (author)
- Mayo Clinic Minnesota
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- Gunderson, Tina M. (author)
- Mayo Clinic Minnesota
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- Achenbach, Sara J. (author)
- Mayo Clinic Minnesota
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- Crowson, Cynthia S. (author)
- Mayo Clinic Minnesota
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- Matteson, Eric L. (author)
- Mayo Clinic Minnesota
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- Turesson, Carl (author)
- Lund University,Lunds universitet,Reumatologi,Forskargrupper vid Lunds universitet,Rheumatology,Lund University Research Groups
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- Wadström, Karin (author)
- Lund University,Lunds universitet,Reumatologi,Forskargrupper vid Lunds universitet,Rheumatology,Lund University Research Groups,Stockholm Regional Council
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- Weyand, Cornelia (author)
- Mayo Clinic Minnesota
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- Koster, Matthew J. (author)
- Mayo Clinic Minnesota
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- Warrington, Kenneth J. (author)
- Mayo Clinic Minnesota
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(creator_code:org_t)
- 2022-12-15
- 2023
- English 6 s.
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In: The Journal of rheumatology. - : The Journal of Rheumatology. - 0315-162X .- 1499-2752. ; 50:4, s. 526-531
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Abstract
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- OBJECTIVE: To assess the frequency of comorbidities and metabolic risk factors at and prior to giant cell arteritis (GCA) diagnosis. METHODS: This is a retrospective case control study of patients with incident GCA between January 1, 2000, and December 31, 2019, in Olmsted County, Minnesota. Two age- and sex-matched controls were identified, and each assigned an index date corresponding to an incidence date of GCA. Medical records were manually abstracted for comorbidities and laboratory data at incidence date, 5 years, and 10 years prior to incidence date. Twenty-five chronic conditions using International Classification of Diseases, 9th revision, diagnosis codes were also studied at incidence date and 5 years prior to incidence date. RESULTS: One hundred and twenty-nine patients with GCA (74% female) and 253 controls were identified. At incidence date, the prevalence of diabetes mellitus (DM) was lower among patients with GCA (5% vs 17%; P = 0.001). At 5 years prior to incidence date, patients were less likely to have DM (2% vs 13%; P < 0.001) and hypertension (27% vs 45%; P = 0.002) and had a lower mean number (SD) of comorbidities (0.7 [1.0] vs 1.3 [1.4]; P < 0.001) compared to controls. Moreover, patients had significantly lower median fasting blood glucose (FBG; 96 mg/dL vs 104 mg/dL; P < 0.001) and BMI (25.8 vs 27.7; P = 0.02) compared to controls. Multivariable logistic regression analysis revealed negative associations for FBG with GCA at 5 and 10 years prior to diagnosis/index date. CONCLUSION: DM prevalence and median FBG and BMI were lower in patients with GCA up to 5 years prior to diagnosis, suggesting that metabolic factors influence the risk of GCA.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
Keyword
- comorbidity
- diabetes mellitus
- epidemiology
- giant cell arteritis
- incidence
- vasculitis
Publication and Content Type
- art (subject category)
- ref (subject category)
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Elfishawi, Mohan ...
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Rakholiya, Jigis ...
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Gunderson, Tina ...
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Achenbach, Sara ...
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Crowson, Cynthia ...
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Matteson, Eric L ...
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show more...
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Turesson, Carl
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Wadström, Karin
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Weyand, Cornelia
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Koster, Matthew ...
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Warrington, Kenn ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Rheumatology and ...
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The Journal of r ...
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Lund University