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Early and late inva...
Early and late invasive pneumococcal infection following stem cell transplantation: a European Bone Marrow Transplantation survey
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Engelhard, D (author)
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Cordonnier, C (author)
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Shaw, PJ (author)
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Parkalli, T (author)
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Guenther, C (author)
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Martino, R (author)
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Dekker, AW (author)
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Prentice, HG (author)
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- Gustavsson, Anita (author)
- Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine
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Nurnberger, W (author)
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- Ljungman, P (author)
- Karolinska Institutet
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(creator_code:org_t)
- 2002-04-25
- 2002
- English.
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In: British Journal of Haematology. - : Wiley. - 0007-1048. ; 117:2, s. 444-450
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Abstract
Subject headings
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- Streptococcus pneumoniae (S. pneumoniae) may cause severe and lethal infections months and years following stem cell transplantation (SCT). In a prospective survey over a 3.5-year period, we assessed the incidence, risk factors and outcome for invasive pneumococcal infection (IPI) following SCT. Fifty-one episodes of IPI were reported: 43 episodes after bone marrow transplantation (BMT) and 8 after peripheral blood stem cell transplantation (PBSCT); 35 after allogeneic SCT and 16 after autologous SCT. Seven IPI episodes, all bacteraemias, were defined as early, occurring 1-35 d (median 3 d) post transplantation. Forty-four episodes were defined as late (greater than or equal to 100 d post SCT), occurring 4 months to 10 years (median 17 months) post transplantation. The incidences of early and late IPI were 2.03/1000 and 8.63/1000 transplantations respectively (P = 0.001). A higher incidence of late IPI was observed after BMT than after PBSCT (10.99 versus 3.23/1000; P < 0.01) and after allogeneic versus autologous SCT (12.20 versus 4.60/1000; P < 0.01). There was a higher estimated incidence of IPI in allogeneic patients with than in those without graft-versus-host disease (GVHD) (18.85 versus 8.25/1000; P = 0.015). The mortality rate was 20%, including 2/7 of early and 8/44 of late IPI. S. pneumoniae is a rare but important complication during the aplastic phase after SCT. In conclusion, S. pneumoniae is a significant cause of morbidity late post-transplantation, especially in allogeneic patients, and particularly those with GVHD. The high IPI mortality rate, both early and late post-transplantation, requires preventive approaches, mainly effective immunization.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
Keyword
- pneumonia
- bacteraemia
- Streptococcus pneumoniae
- stem cell transplantation
- graft-versus-host disease
Publication and Content Type
- art (subject category)
- ref (subject category)
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To the university's database
- By the author/editor
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Engelhard, D
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Cordonnier, C
-
Shaw, PJ
-
Parkalli, T
-
Guenther, C
-
Martino, R
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show more...
-
Dekker, AW
-
Prentice, HG
-
Gustavsson, Anit ...
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Nurnberger, W
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Ljungman, P
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Hematology
- Articles in the publication
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British Journal ...
- By the university
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Lund University
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Karolinska Institutet