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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003906naa a2200505 4500
001oai:lup.lub.lu.se:d78859c5-337d-4c8a-a88d-164515ca0c94
003SwePub
008160401s2013 | |||||||||||000 ||eng|
0247 a https://lup.lub.lu.se/record/37482962 URI
0247 a https://doi.org/10.1136/gutjnl-2012-3027172 DOI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a van Schaik, Fiona D. M.4 aut
2451 0a Serological markers predict inflammatory bowel disease years before the diagnosis
264 c 2012-07-26
264 1b BMJ,c 2013
520 a Objective Anti-neutrophil cytoplasmic antibodies and anti-Saccharomyces cerevisiae mannan antibodies (ASCAs) have been detected in the serum of patients with ulcerative colitis (UC) and Crohn's disease (CD) and their unaffected family members. The aim of this study was to establish the value of serological markers as predictors of UC and CD. Design Individuals who developed CD or UC were identified from the European Prospective Investigation into Cancer and Nutrition (EPIC) study. At recruitment, none of the participants had a diagnosis of CD or UC. For each incident case, two controls were randomly selected matched for centre, date of birth, sex, date of recruitment and time of follow-up. Serum of cases and controls obtained at recruitment were analysed for ASCA IgG, ASCA IgA, perinuclear anti-neutrophil cytoplasmic antibody (pANCA), antibodies against Escherichia coli outer membrane porin C (OmpC) and flagellin CBir1. Conditional logistic regression was used to determine risk of CD and UC. Receiver operating characteristic curves were constructed to test accuracy. Results A total of 77 individuals were diagnosed with CD and 167 with UC after a mean follow-up of 4.5 (SD 3.2) and 4.4 (SD 3.1) years following blood collection, respectively. Combinations of pANCA, ASCA, anti-CBir1 and anti-OmpC were most accurate in predicting incident CD and UC (area under curve 0.679 and 0.657, respectively). The predictive value of the combination of markers increased when time to diagnosis of CD or UC decreased. Conclusion A panel of serological markers is able to predict development of CD and UC in individuals from a low-risk population.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Gastroenterologi0 (SwePub)302132 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Gastroenterology and Hepatology0 (SwePub)302132 hsv//eng
7001 a Oldenburg, Bas4 aut
7001 a Hart, Andrew R.4 aut
7001 a Siersema, Peter D.4 aut
7001 a Lindgren, Stefanu Lund University,Lunds universitet,Gastroenterologi,Forskargrupper vid Lunds universitet,Gastroenterology,Lund University Research Groups4 aut0 (Swepub:lu)medf-sli
7001 a Grip, Olofu Lund University,Lunds universitet,Gastroenterologi,Forskargrupper vid Lunds universitet,Gastroenterology,Lund University Research Groups4 aut0 (Swepub:lu)medf-ogr
7001 a Teucher, Birgit4 aut
7001 a Kaaks, Rudolf4 aut
7001 a Bergmann, Manuela M.4 aut
7001 a Boeing, Heiner4 aut
7001 a Carbonnel, Franck4 aut
7001 a Jantchou, Prevost4 aut
7001 a Boutron-Ruault, Marie-Christine4 aut
7001 a Tjonneland, Anne4 aut
7001 a Olsen, Anja4 aut
7001 a Crowe, Francesca L.4 aut
7001 a Peeters, Petra H. M.4 aut
7001 a van Oijen, Martijn G. H.4 aut
7001 a Bueno-de-Mesquita, H. Bas4 aut
7102 a Gastroenterologib Forskargrupper vid Lunds universitet4 org
7730 t Gutd : BMJg 62:5, s. 683-688q 62:5<683-688x 1468-3288x 0017-5749
8564 u http://dx.doi.org/10.1136/gutjnl-2012-302717y FULLTEXT
8564 8u https://lup.lub.lu.se/record/3748296
8564 8u https://doi.org/10.1136/gutjnl-2012-302717

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