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Long-Term Results o...
Long-Term Results of a Multicenter Study on Subthalamic and Pallidal Stimulation in Parkinson's Disease
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Moro, Elena (author)
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Lozano, Andres M. (author)
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Pollak, Pierre (author)
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Agid, Yves (author)
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- Rehncrona, Stig (author)
- Lund University,Lunds universitet,Neurokirurgi,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neurosurgery,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine
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Volkmann, Jens (author)
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Kulisevsky, Jaime (author)
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Obeso, Jose A. (author)
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Albanese, Alberto (author)
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Hariz, Marwan I. (author)
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Quinn, Niall P. (author)
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Speelman, Jans D. (author)
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Benabid, Alim L. (author)
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Fraix, Valerie (author)
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Mendes, Alexandre (author)
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Welter, Marie-Laure (author)
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Houeto, Jean-Luc (author)
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Cornu, Philippe (author)
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Dormont, Didier (author)
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- Törnqvist, Anna Lena (author)
- Lund University,Lunds universitet,Neurokirurgi,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neurosurgery,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine
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Ekberg, Ron (author)
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Schnitzler, Alfons (author)
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Timmermann, Lars (author)
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Wojtecki, Lars (author)
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Gironell, Andres (author)
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Rodriguez-Oroz, Maria C. (author)
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Guridi, Jorge (author)
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Bentivoglio, Anna R. (author)
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Contarino, Maria F. (author)
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Romito, Luigi (author)
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Scerrati, Massimo (author)
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Janssens, Marc (author)
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Lang, Anthony E. (author)
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(creator_code:org_t)
- 2010-03-08
- 2010
- English.
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In: Movement Disorders. - : Wiley. - 0885-3185. ; 25:5, s. 578-586
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
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- We report the 5 to 6 year follow-up of a multicenter study of bilateral subthalamic nucleus (STN) and globus pallidus internus (GPi) deep brain stimulation (DBS) in advanced Parkinson's disease (PD) patients. Thirty-live STN patients and 16 GPi patienis were assessed at 5 to 6 years after DBS surgery. Primary outcome measure was the stimulation effect on the motor Unified Parkinson's Disease Rating Scale (UPDRS) assessed with a prospective cross-over double-blind assessment without medications (stimulation was randomly switched on or off). Secondary outcomes were motor UPDRS changes with unblinded assessments in off- and on-medication states with and without stimulation, activities of daily living (ADL), anti-PD medications, and dyskinesias. In double-blind assessment, both STN and GPi DBS were significantly effective in improving the motor UPDRS scores (STN. P < 0.0001, 45.4%; GPi, P = 0.008, 20.0%) compared with of regardless of the sequence of stimulation. In open assessment. both STN- and GPi-DBS significantly improved the off-medication motor UPDRS when compared with before surgery (STN. P < 0.001, 50.5%; GPi, P = 0.002, 35.6%). Dyskinesias and ADL were significantly improved in both groups. Anti-PD medications were significantly reduced only in the STN group. Adverse events were more frequent in the STN group. These results confirm the long-term efficacy of STN and GPi DBS advanced PD. Although the surgical targets were not randomized, there was a trend to 1 better outcome of motor signs in the STN-DBS patients and fewer adverse events in the GPi-DBS group. (C) 2010 Movement Disorder Society
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Keyword
- subthalamic nucleus
- globus pallidus internus
- Parkinson's disease
- deep brain stimulation
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Moro, Elena
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Lozano, Andres M ...
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Pollak, Pierre
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Agid, Yves
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Rehncrona, Stig
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Volkmann, Jens
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show more...
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Kulisevsky, Jaim ...
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Obeso, Jose A.
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Albanese, Albert ...
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Hariz, Marwan I.
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Quinn, Niall P.
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Speelman, Jans D ...
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Benabid, Alim L.
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Fraix, Valerie
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Mendes, Alexandr ...
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Welter, Marie-La ...
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Houeto, Jean-Luc
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Cornu, Philippe
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Dormont, Didier
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Törnqvist, Anna ...
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Ekberg, Ron
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Schnitzler, Alfo ...
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Timmermann, Lars
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Wojtecki, Lars
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Gironell, Andres
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Rodriguez-Oroz, ...
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Guridi, Jorge
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Bentivoglio, Ann ...
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Contarino, Maria ...
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Romito, Luigi
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Scerrati, Massim ...
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Janssens, Marc
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Lang, Anthony E.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
- Articles in the publication
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Movement Disorde ...
- By the university
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Lund University