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Long-Term Results o...
Long-Term Results of a Multicenter Study on Subthalamic and Pallidal Stimulation in Parkinson's Disease
- Article/chapterEnglish2010
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LIBRIS-ID:oai:lup.lub.lu.se:d79dc53a-7e1c-4c8f-a929-351867001264
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https://lup.lub.lu.se/record/1619311URI
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https://doi.org/10.1002/mds.22735DOI
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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We report the 5 to 6 year follow-up of a multicenter study of bilateral subthalamic nucleus (STN) and globus pallidus internus (GPi) deep brain stimulation (DBS) in advanced Parkinson's disease (PD) patients. Thirty-live STN patients and 16 GPi patienis were assessed at 5 to 6 years after DBS surgery. Primary outcome measure was the stimulation effect on the motor Unified Parkinson's Disease Rating Scale (UPDRS) assessed with a prospective cross-over double-blind assessment without medications (stimulation was randomly switched on or off). Secondary outcomes were motor UPDRS changes with unblinded assessments in off- and on-medication states with and without stimulation, activities of daily living (ADL), anti-PD medications, and dyskinesias. In double-blind assessment, both STN and GPi DBS were significantly effective in improving the motor UPDRS scores (STN. P < 0.0001, 45.4%; GPi, P = 0.008, 20.0%) compared with of regardless of the sequence of stimulation. In open assessment. both STN- and GPi-DBS significantly improved the off-medication motor UPDRS when compared with before surgery (STN. P < 0.001, 50.5%; GPi, P = 0.002, 35.6%). Dyskinesias and ADL were significantly improved in both groups. Anti-PD medications were significantly reduced only in the STN group. Adverse events were more frequent in the STN group. These results confirm the long-term efficacy of STN and GPi DBS advanced PD. Although the surgical targets were not randomized, there was a trend to 1 better outcome of motor signs in the STN-DBS patients and fewer adverse events in the GPi-DBS group. (C) 2010 Movement Disorder Society
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Lozano, Andres M.
(author)
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Pollak, Pierre
(author)
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Agid, Yves
(author)
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Rehncrona, StigLund University,Lunds universitet,Neurokirurgi,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neurosurgery,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)nkir-sre
(author)
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Volkmann, Jens
(author)
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Kulisevsky, Jaime
(author)
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Obeso, Jose A.
(author)
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Albanese, Alberto
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Hariz, Marwan I.
(author)
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Quinn, Niall P.
(author)
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Speelman, Jans D.
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Benabid, Alim L.
(author)
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Fraix, Valerie
(author)
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Mendes, Alexandre
(author)
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Welter, Marie-Laure
(author)
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Houeto, Jean-Luc
(author)
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Cornu, Philippe
(author)
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Dormont, Didier
(author)
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Törnqvist, Anna LenaLund University,Lunds universitet,Neurokirurgi,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neurosurgery,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)neur-ato
(author)
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Ekberg, Ron
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Schnitzler, Alfons
(author)
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Timmermann, Lars
(author)
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Wojtecki, Lars
(author)
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Gironell, Andres
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Rodriguez-Oroz, Maria C.
(author)
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Guridi, Jorge
(author)
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Bentivoglio, Anna R.
(author)
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Contarino, Maria F.
(author)
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Romito, Luigi
(author)
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Scerrati, Massimo
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Janssens, Marc
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Lang, Anthony E.
(author)
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NeurokirurgiSektion IV
(creator_code:org_t)
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In:Movement Disorders: Wiley25:5, s. 578-5860885-3185
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Moro, Elena
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Lozano, Andres M ...
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Pollak, Pierre
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Agid, Yves
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Rehncrona, Stig
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Volkmann, Jens
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Kulisevsky, Jaim ...
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Obeso, Jose A.
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Albanese, Albert ...
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Hariz, Marwan I.
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Quinn, Niall P.
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Speelman, Jans D ...
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Benabid, Alim L.
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Fraix, Valerie
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Mendes, Alexandr ...
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Welter, Marie-La ...
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Houeto, Jean-Luc
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Cornu, Philippe
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Dormont, Didier
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Törnqvist, Anna ...
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Ekberg, Ron
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Schnitzler, Alfo ...
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Timmermann, Lars
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Wojtecki, Lars
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Gironell, Andres
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Rodriguez-Oroz, ...
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Guridi, Jorge
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Bentivoglio, Ann ...
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Contarino, Maria ...
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Romito, Luigi
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Scerrati, Massim ...
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Janssens, Marc
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Lang, Anthony E.
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Lund University