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Survival of rats wi...
Survival of rats with N29 brain tumours after irradiation with 5 or 15 Gy and immunization with IFN-gamma secreting tumour cells
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- Persson, Bertil R (author)
- Lund University,Lunds universitet,Rausinglaboratoriet i Lund - Tumörsektionen,Forskargrupper vid Lunds universitet,Rausing laboratory of Lund - Tumor section,Lund University Research Groups
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- Baureus Koch, Catrin (author)
- Lund University,Lunds universitet,Rausinglaboratoriet i Lund - Tumörsektionen,Forskargrupper vid Lunds universitet,Rausing laboratory of Lund - Tumor section,Lund University Research Groups
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- Grafström, Gustav (author)
- Lund University,Lunds universitet,Rausinglaboratoriet i Lund - Tumörsektionen,Forskargrupper vid Lunds universitet,Rausing laboratory of Lund - Tumor section,Lund University Research Groups
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- Ceberg, Crister (author)
- Lund University,Lunds universitet,Medicinsk strålningsfysik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Medical Radiation Physics, Lund,Section V,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Munck af Rosenschöld, Per (author)
- Lund University,Lunds universitet,Medicinsk strålningsfysik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Medical Radiation Physics, Lund,Section V,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Widegren, Bengt (author)
- Lund University,Lunds universitet,Rausinglaboratoriet i Lund - Tumörsektionen,Forskargrupper vid Lunds universitet,Rausing laboratory of Lund - Tumor section,Lund University Research Groups
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- Salford, Leif (author)
- Lund University,Lunds universitet,Rausinglaboratoriet i Lund - Tumörsektionen,Forskargrupper vid Lunds universitet,Rausing laboratory of Lund - Tumor section,Lund University Research Groups
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(creator_code:org_t)
- 2008
- 2008
- English.
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In: BioMedical Engineering and Informatics : New Development and the Future - Proceedings of the 1st International Conference on BioMedical Engineering and Informatics, BMEI 2008 - New Development and the Future - Proceedings of the 1st International Conference on BioMedical Engineering and Informatics, BMEI 2008. - 9780769531182 ; 2, s. 243-247
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Abstract
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- Intra cerebral tumours were inoculated into the brain of Fischer-344 syngeneic rats. After one week they were treated with either 5 or 15 Gy of Co-60-gamma radiation. The first immunization was given 1 hour before the radiation treatment and then two more times with 14-day intervals. Immunization was performed with 3 x 10(6) radiation sterilized IFN-gamma secreting tumour cells (N29) injected intraperitoneally. Neither radiation therapy with 5 or 15 Gy nor immunization with N29 cells alone had any significant effect on the length of survival of N29 tumour bearing rats. But radiation therapy with 5 Gy combined with immunization with IFN-gamma secreting syngeneic N29 cells resulted in 63 % complete remissions and significantly (p < 0.05) increased survival for the tumour bearing rats. Corresponding combination with 15 Gy RT resulted in 50% complete remissions. There is a possibility of a synergistic effect by optimal combination of radiation therapy and immunization.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
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- kon (subject category)
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