Survival of rats with N29 brain tumours after irradiation with 5 or 15 Gy and immunization with IFN-gamma secreting tumour cells

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Persson, Bertil RLund University,Lunds universitet,Rausinglaboratoriet i Lund - Tumörsektionen,Forskargrupper vid Lunds universitet,Rausing laboratory of Lund - Tumor section,Lund University Research Groups (author)

Survival of rats with N29 brain tumours after irradiation with 5 or 15 Gy and immunization with IFN-gamma secreting tumour cells

Article/chapterEnglish2008

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2008

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LIBRIS-ID:oai:lup.lub.lu.se:d7a364b9-4489-4668-973e-83e0ff2e97d8
https://lup.lub.lu.se/record/1406835URI
https://doi.org/10.1109/BMEI.2008.345DOI

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Intra cerebral tumours were inoculated into the brain of Fischer-344 syngeneic rats. After one week they were treated with either 5 or 15 Gy of Co-60-gamma radiation. The first immunization was given 1 hour before the radiation treatment and then two more times with 14-day intervals. Immunization was performed with 3 x 10(6) radiation sterilized IFN-gamma secreting tumour cells (N29) injected intraperitoneally. Neither radiation therapy with 5 or 15 Gy nor immunization with N29 cells alone had any significant effect on the length of survival of N29 tumour bearing rats. But radiation therapy with 5 Gy combined with immunization with IFN-gamma secreting syngeneic N29 cells resulted in 63 % complete remissions and significantly (p < 0.05) increased survival for the tumour bearing rats. Corresponding combination with 15 Gy RT resulted in 50% complete remissions. There is a possibility of a synergistic effect by optimal combination of radiation therapy and immunization.

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Baureus Koch, CatrinLund University,Lunds universitet,Rausinglaboratoriet i Lund - Tumörsektionen,Forskargrupper vid Lunds universitet,Rausing laboratory of Lund - Tumor section,Lund University Research Groups(Swepub:lu)radf-cba (author)
Grafström, GustavLund University,Lunds universitet,Rausinglaboratoriet i Lund - Tumörsektionen,Forskargrupper vid Lunds universitet,Rausing laboratory of Lund - Tumor section,Lund University Research Groups(Swepub:lu)rafy-ggr (author)
Ceberg, CristerLund University,Lunds universitet,Medicinsk strålningsfysik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Medical Radiation Physics, Lund,Section V,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)rafy-cce (author)
Munck af Rosenschöld, PerLund University,Lunds universitet,Medicinsk strålningsfysik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Medical Radiation Physics, Lund,Section V,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)pe1188mu (author)
Widegren, BengtLund University,Lunds universitet,Rausinglaboratoriet i Lund - Tumörsektionen,Forskargrupper vid Lunds universitet,Rausing laboratory of Lund - Tumor section,Lund University Research Groups(Swepub:lu)wbl-bwi (author)
Salford, LeifLund University,Lunds universitet,Rausinglaboratoriet i Lund - Tumörsektionen,Forskargrupper vid Lunds universitet,Rausing laboratory of Lund - Tumor section,Lund University Research Groups(Swepub:lu)nkir-lsa (author)
Rausinglaboratoriet i Lund - TumörsektionenForskargrupper vid Lunds universitet (creator_code:org_t)

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In:BioMedical Engineering and Informatics : New Development and the Future - Proceedings of the 1st International Conference on BioMedical Engineering and Informatics, BMEI 2008 - New Development and the Future - Proceedings of the 1st International Conference on BioMedical Engineering and Informatics, BMEI 20082, s. 243-2479780769531182

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Neurology

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