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Genome-wide associa...
Genome-wide association study identifies a sequence variant within the DAB2IP gene conferring susceptibility to abdominal aortic aneurysm
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Gretarsdottir, Solveig (author)
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Baas, Annette F. (author)
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Thorleifsson, Gudmar (author)
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show more...
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Holm, Hilma (author)
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den Heijer, Martin (author)
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de Vries, Jean-Paul P. M. (author)
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Kranendonk, Steef E. (author)
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Zeebregts, Clark J. A. M. (author)
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van Sterkenburg, Steven M. (author)
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Geelkerken, Robert H. (author)
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van Rij, Andre M. (author)
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Williams, Michael J. A. (author)
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Boll, Albert P. M. (author)
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Kostic, Jelena P. (author)
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Jonasdottir, Adalbjorg (author)
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Jonasdottir, Aslaug (author)
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Walters, G. Bragi (author)
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Masson, Gisli (author)
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Sulem, Patrick (author)
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Saemundsdottir, Jona (author)
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Mouy, Magali (author)
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Magnusson, Kristinn P. (author)
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Tromp, Gerard (author)
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Elmore, James R. (author)
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Sakalihasan, Natzi (author)
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Limet, Raymond (author)
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Defraigne, Jean-Olivier (author)
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Ferrell, Robert E. (author)
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Ronkainen, Antti (author)
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Ruigrok, Ynte M. (author)
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Wijmenga, Cisca (author)
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Grobbee, Diederick E. (author)
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Shah, Svati H. (author)
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Granger, Christopher B. (author)
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Quyyumi, Arshed A. (author)
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Vaccarino, Viola (author)
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Patel, Riyaz S. (author)
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Zafari, A. Maziar (author)
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Levey, Allan I. (author)
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Austin, Harland (author)
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Girelli, Domenico (author)
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Pignatti, Pier Franco (author)
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Olivieri, Oliviero (author)
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Martinelli, Nicola (author)
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Malerba, Giovanni (author)
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Trabetti, Elisabetta (author)
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Becker, Lewis C. (author)
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Becker, Diane M. (author)
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Reilly, Muredach P. (author)
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Rader, Daniel J. (author)
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Mueller, Thomas (author)
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Dieplinger, Benjamin (author)
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Haltmayer, Meinhard (author)
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Urbonavicius, Sigitas (author)
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- Lindblad, Bengt (author)
- Lund University,Lunds universitet,Vaskulära sjukdomar - kliniska studier,Forskargrupper vid Lunds universitet,Vascular Diseases - Clinical Research,Lund University Research Groups
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- Gottsäter, Anders (author)
- Lund University,Lunds universitet,Vaskulära sjukdomar - kliniska studier,Forskargrupper vid Lunds universitet,Vascular Diseases - Clinical Research,Lund University Research Groups
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Gaetani, Eleonora (author)
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Pola, Roberto (author)
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Wells, Philip (author)
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Rodger, Marc (author)
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Forgie, Melissa (author)
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Langlois, Nicole (author)
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Corral, Javier (author)
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Vicente, Vicente (author)
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Fontcuberta, Jordi (author)
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Espana, Francisco (author)
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Grarup, Niels (author)
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Jorgensen, Torben (author)
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Witte, Daniel R. (author)
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Hansen, Torben (author)
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Pedersen, Oluf (author)
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Aben, Katja K. (author)
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de Graaf, Jacqueline (author)
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Holewijn, Suzanne (author)
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- Folkersen, Lasse (author)
- Karolinska Institutet
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- Franco-Cereceda, Anders (author)
- Karolinska Institutet
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- Eriksson, Per (author)
- Karolinska Institutet
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Collier, David A. (author)
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Stefansson, Hreinn (author)
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Steinthorsdottir, Valgerdur (author)
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Rafnar, Thorunn (author)
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Valdimarsson, Einar M. (author)
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Magnadottir, Hulda B. (author)
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Sveinbjornsdottir, Sigurlaug (author)
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Olafsson, Isleifur (author)
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Magnusson, Magnus Karl (author)
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Palmason, Robert (author)
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Haraldsdottir, Vilhelmina (author)
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Andersen, Karl (author)
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Onundarson, Pall T. (author)
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Thorgeirsson, Gudmundur (author)
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Kiemeney, Lambertus A. (author)
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Powell, Janet T. (author)
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Carey, David J. (author)
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Kuivaniemi, Helena (author)
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Lindholt, Jes S. (author)
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Jones, Gregory T. (author)
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Kong, Augustine (author)
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Blankensteijn, Jan D. (author)
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Matthiasson, Stefan E. (author)
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Thorsteinsdottir, Unnur (author)
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Stefansson, Kari (author)
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(creator_code:org_t)
- 2010-07-11
- 2010
- English.
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In: Nature Genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 42:8, s. 71-692
- Related links:
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http://dx.doi.org/10...
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https://europepmc.or...
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Abstract
Subject headings
Close
- We performed a genome-wide association study on 1,292 individuals with abdominal aortic aneurysms (AAAs) and 30,503 controls from Iceland and The Netherlands, with a follow-up of top markers in up to 3,267 individuals with AAAs and 7,451 controls. The A allele of rs7025486 on 9q33 was found to associate with AAA, with an odds ratio (OR) of 1.21 and P = 4.6 x 10(-10). In tests for association with other vascular diseases, we found that rs7025486[A] is associated with early onset myocardial infarction (OR = 1.18, P = 3.1 x 10(-5)), peripheral arterial disease (OR = 1.14, P = 3.9 x 10(-5)) and pulmonary embolism (OR = 1.20, P = 0.00030), but not with intracranial aneurysm or ischemic stroke. No association was observed between rs7025486[A] and common risk factors for arterial and venous diseases-that is, smoking, lipid levels, obesity, type 2 diabetes and hypertension. Rs7025486 is located within DAB2IP, which encodes an inhibitor of cell growth and survival.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
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- art (subject category)
- ref (subject category)
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- By the author/editor
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Gretarsdottir, S ...
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Baas, Annette F.
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Thorleifsson, Gu ...
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Holm, Hilma
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den Heijer, Mart ...
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de Vries, Jean-P ...
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show more...
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Kranendonk, Stee ...
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Zeebregts, Clark ...
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van Sterkenburg, ...
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Geelkerken, Robe ...
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van Rij, Andre M ...
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Williams, Michae ...
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Boll, Albert P. ...
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Kostic, Jelena P ...
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Jonasdottir, Ada ...
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Jonasdottir, Asl ...
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Walters, G. Brag ...
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Masson, Gisli
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Sulem, Patrick
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Saemundsdottir, ...
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Mouy, Magali
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Magnusson, Krist ...
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Tromp, Gerard
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Elmore, James R.
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Sakalihasan, Nat ...
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Limet, Raymond
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Defraigne, Jean- ...
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Ferrell, Robert ...
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Ronkainen, Antti
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Ruigrok, Ynte M.
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Wijmenga, Cisca
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Grobbee, Diederi ...
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Shah, Svati H.
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Granger, Christo ...
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Quyyumi, Arshed ...
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Vaccarino, Viola
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Patel, Riyaz S.
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Zafari, A. Mazia ...
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Levey, Allan I.
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Austin, Harland
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Girelli, Domenic ...
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Pignatti, Pier F ...
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Olivieri, Olivie ...
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Martinelli, Nico ...
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Malerba, Giovann ...
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Trabetti, Elisab ...
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Becker, Lewis C.
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Becker, Diane M.
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Reilly, Muredach ...
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Rader, Daniel J.
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Mueller, Thomas
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Dieplinger, Benj ...
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Haltmayer, Meinh ...
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Urbonavicius, Si ...
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Lindblad, Bengt
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Gottsäter, Ander ...
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Gaetani, Eleonor ...
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Pola, Roberto
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Wells, Philip
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Rodger, Marc
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Forgie, Melissa
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Langlois, Nicole
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Corral, Javier
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Vicente, Vicente
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Fontcuberta, Jor ...
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Espana, Francisc ...
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Grarup, Niels
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Jorgensen, Torbe ...
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Witte, Daniel R.
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Hansen, Torben
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Pedersen, Oluf
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Aben, Katja K.
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de Graaf, Jacque ...
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Holewijn, Suzann ...
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Folkersen, Lasse
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Franco-Cereceda, ...
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Eriksson, Per
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Collier, David A ...
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Stefansson, Hrei ...
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Steinthorsdottir ...
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Rafnar, Thorunn
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Valdimarsson, Ei ...
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Magnadottir, Hul ...
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Sveinbjornsdotti ...
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Olafsson, Isleif ...
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Magnusson, Magnu ...
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Palmason, Robert
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Haraldsdottir, V ...
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Andersen, Karl
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Onundarson, Pall ...
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Thorgeirsson, Gu ...
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Kiemeney, Lamber ...
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Powell, Janet T.
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Carey, David J.
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Kuivaniemi, Hele ...
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Lindholt, Jes S.
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Jones, Gregory T ...
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Kong, Augustine
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Blankensteijn, J ...
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Matthiasson, Ste ...
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Thorsteinsdottir ...
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Stefansson, Kari
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
- Articles in the publication
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Nature Genetics
- By the university
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Lund University
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Karolinska Institutet