Genome-wide association study identifies a sequence variant within the DAB2IP gene conferring susceptibility to abdominal aortic aneurysm

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Gretarsdottir, Solveig (author)

Genome-wide association study identifies a sequence variant within the DAB2IP gene conferring susceptibility to abdominal aortic aneurysm

Article/chapterEnglish2010

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2010-07-11
Springer Science and Business Media LLC,2010

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LIBRIS-ID:oai:lup.lub.lu.se:d7ad61fd-a9d2-4d5f-91f9-0c0fd8eedd89
https://lup.lub.lu.se/record/1677884URI
https://doi.org/10.1038/ng.622DOI
http://kipublications.ki.se/Default.aspx?queryparsed=id:121097195URI

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Language:English
Summary in:English

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Subject category:art swepub-publicationtype
Subject category:ref swepub-contenttype

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We performed a genome-wide association study on 1,292 individuals with abdominal aortic aneurysms (AAAs) and 30,503 controls from Iceland and The Netherlands, with a follow-up of top markers in up to 3,267 individuals with AAAs and 7,451 controls. The A allele of rs7025486 on 9q33 was found to associate with AAA, with an odds ratio (OR) of 1.21 and P = 4.6 x 10(-10). In tests for association with other vascular diseases, we found that rs7025486[A] is associated with early onset myocardial infarction (OR = 1.18, P = 3.1 x 10(-5)), peripheral arterial disease (OR = 1.14, P = 3.9 x 10(-5)) and pulmonary embolism (OR = 1.20, P = 0.00030), but not with intracranial aneurysm or ischemic stroke. No association was observed between rs7025486[A] and common risk factors for arterial and venous diseases-that is, smoking, lipid levels, obesity, type 2 diabetes and hypertension. Rs7025486 is located within DAB2IP, which encodes an inhibitor of cell growth and survival.

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Baas, Annette F. (author)
Thorleifsson, Gudmar (author)
Holm, Hilma (author)
den Heijer, Martin (author)
de Vries, Jean-Paul P. M. (author)
Kranendonk, Steef E. (author)
Zeebregts, Clark J. A. M. (author)
van Sterkenburg, Steven M. (author)
Geelkerken, Robert H. (author)
van Rij, Andre M. (author)
Williams, Michael J. A. (author)
Boll, Albert P. M. (author)
Kostic, Jelena P. (author)
Jonasdottir, Adalbjorg (author)
Jonasdottir, Aslaug (author)
Walters, G. Bragi (author)
Masson, Gisli (author)
Sulem, Patrick (author)
Saemundsdottir, Jona (author)
Mouy, Magali (author)
Magnusson, Kristinn P. (author)
Tromp, Gerard (author)
Elmore, James R. (author)
Sakalihasan, Natzi (author)
Limet, Raymond (author)
Defraigne, Jean-Olivier (author)
Ferrell, Robert E. (author)
Ronkainen, Antti (author)
Ruigrok, Ynte M. (author)
Wijmenga, Cisca (author)
Grobbee, Diederick E. (author)
Shah, Svati H. (author)
Granger, Christopher B. (author)
Quyyumi, Arshed A. (author)
Vaccarino, Viola (author)
Patel, Riyaz S. (author)
Zafari, A. Maziar (author)
Levey, Allan I. (author)
Austin, Harland (author)
Girelli, Domenico (author)
Pignatti, Pier Franco (author)
Olivieri, Oliviero (author)
Martinelli, Nicola (author)
Malerba, Giovanni (author)
Trabetti, Elisabetta (author)
Becker, Lewis C. (author)
Becker, Diane M. (author)
Reilly, Muredach P. (author)
Rader, Daniel J. (author)
Mueller, Thomas (author)
Dieplinger, Benjamin (author)
Haltmayer, Meinhard (author)
Urbonavicius, Sigitas (author)
Lindblad, BengtLund University,Lunds universitet,Vaskulära sjukdomar - kliniska studier,Forskargrupper vid Lunds universitet,Vascular Diseases - Clinical Research,Lund University Research Groups(Swepub:lu)kir-bli (author)
Gottsäter, AndersLund University,Lunds universitet,Vaskulära sjukdomar - kliniska studier,Forskargrupper vid Lunds universitet,Vascular Diseases - Clinical Research,Lund University Research Groups(Swepub:lu)medf-ago (author)
Gaetani, Eleonora (author)
Pola, Roberto (author)
Wells, Philip (author)
Rodger, Marc (author)
Forgie, Melissa (author)
Langlois, Nicole (author)
Corral, Javier (author)
Vicente, Vicente (author)
Fontcuberta, Jordi (author)
Espana, Francisco (author)
Grarup, Niels (author)
Jorgensen, Torben (author)
Witte, Daniel R. (author)
Hansen, Torben (author)
Pedersen, Oluf (author)
Aben, Katja K. (author)
de Graaf, Jacqueline (author)
Holewijn, Suzanne (author)
Folkersen, LasseKarolinska Institutet (author)
Franco-Cereceda, AndersKarolinska Institutet (author)
Eriksson, PerKarolinska Institutet (author)
Collier, David A. (author)
Stefansson, Hreinn (author)
Steinthorsdottir, Valgerdur (author)
Rafnar, Thorunn (author)
Valdimarsson, Einar M. (author)
Magnadottir, Hulda B. (author)
Sveinbjornsdottir, Sigurlaug (author)
Olafsson, Isleifur (author)
Magnusson, Magnus Karl (author)
Palmason, Robert (author)
Haraldsdottir, Vilhelmina (author)
Andersen, Karl (author)
Onundarson, Pall T. (author)
Thorgeirsson, Gudmundur (author)
Kiemeney, Lambertus A. (author)
Powell, Janet T. (author)
Carey, David J. (author)
Kuivaniemi, Helena (author)
Lindholt, Jes S. (author)
Jones, Gregory T. (author)
Kong, Augustine (author)
Blankensteijn, Jan D. (author)
Matthiasson, Stefan E. (author)
Thorsteinsdottir, Unnur (author)
Stefansson, Kari (author)
Vaskulära sjukdomar - kliniska studierForskargrupper vid Lunds universitet (creator_code:org_t)

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In:Nature Genetics: Springer Science and Business Media LLC42:8, s. 71-6921546-17181061-4036

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By the author/editor: Gretarsdottir, S ...; Baas, Annette F.; Thorleifsson, Gu ...; Holm, Hilma; den Heijer, Mart ...; de Vries, Jean-P ...; show more...; Kranendonk, Stee ...; Zeebregts, Clark ...; van Sterkenburg, ...; Geelkerken, Robe ...; van Rij, Andre M ...; Williams, Michae ...; Boll, Albert P. ...; Kostic, Jelena P ...; Jonasdottir, Ada ...; Jonasdottir, Asl ...; Walters, G. Brag ...; Masson, Gisli; Sulem, Patrick; Saemundsdottir, ...; Mouy, Magali; Magnusson, Krist ...; Tromp, Gerard; Elmore, James R.; Sakalihasan, Nat ...; Limet, Raymond; Defraigne, Jean- ...; Ferrell, Robert ...; Ronkainen, Antti; Ruigrok, Ynte M.; Wijmenga, Cisca; Grobbee, Diederi ...; Shah, Svati H.; Granger, Christo ...; Quyyumi, Arshed ...; Vaccarino, Viola; Patel, Riyaz S.; Zafari, A. Mazia ...; Levey, Allan I.; Austin, Harland; Girelli, Domenic ...; Pignatti, Pier F ...; Olivieri, Olivie ...; Martinelli, Nico ...; Malerba, Giovann ...; Trabetti, Elisab ...; Becker, Lewis C.; Becker, Diane M.; Reilly, Muredach ...; Rader, Daniel J.; Mueller, Thomas; Dieplinger, Benj ...; Haltmayer, Meinh ...; Urbonavicius, Si ...; Lindblad, Bengt; Gottsäter, Ander ...; Gaetani, Eleonor ...; Pola, Roberto; Wells, Philip; Rodger, Marc; Forgie, Melissa; Langlois, Nicole; Corral, Javier; Vicente, Vicente; Fontcuberta, Jor ...; Espana, Francisc ...; Grarup, Niels; Jorgensen, Torbe ...; Witte, Daniel R.; Hansen, Torben; Pedersen, Oluf; Aben, Katja K.; de Graaf, Jacque ...; Holewijn, Suzann ...; Folkersen, Lasse; Franco-Cereceda, ...; Eriksson, Per; Collier, David A ...; Stefansson, Hrei ...; Steinthorsdottir ...; Rafnar, Thorunn; Valdimarsson, Ei ...; Magnadottir, Hul ...; Sveinbjornsdotti ...; Olafsson, Isleif ...; Magnusson, Magnu ...; Palmason, Robert; Haraldsdottir, V ...; Andersen, Karl; Onundarson, Pall ...; Thorgeirsson, Gu ...; Kiemeney, Lamber ...; Powell, Janet T.; Carey, David J.; Kuivaniemi, Hele ...; Lindholt, Jes S.; Jones, Gregory T ...; Kong, Augustine; Blankensteijn, J ...; Matthiasson, Ste ...; Thorsteinsdottir ...; Stefansson, Kari; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Cardiac and Card ...

Articles in the publication: Nature Genetics

By the university: Lund University; Karolinska Institutet

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