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Thermal stability a...
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Regenthal, PaulinaLund University,Lunds universitet,Medicinsk strukturbiologi,Forskargrupper vid Lunds universitet,Medical Structural Biology,Lund University Research Groups
(author)
Thermal stability and structural changes in bacterial toxins responsible for food poisoning
- Article/chapterEnglish2017
Publisher, publication year, extent ...
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2017-02-16
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Public Library of Science (PLoS),2017
Numbers
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LIBRIS-ID:oai:lup.lub.lu.se:d7f4ba54-37da-46c8-aba4-70fd5dafb1f4
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https://lup.lub.lu.se/record/d7f4ba54-37da-46c8-aba4-70fd5dafb1f4URI
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https://doi.org/10.1371/journal.pone.0172445DOI
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Language:English
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Summary in:English
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Subject category:art swepub-publicationtype
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Subject category:ref swepub-contenttype
Notes
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The staphylococcal enterotoxins (SEs) are secreted by the bacteria Staphylococcus aureus and are the most common causative agent in staphylococcal food poisoning. The staphylococcal enterotoxin A (SEA) has been associated with large staphylococcal food poisoning outbreaks, but newer identified SEs, like staphylococcal enterotoxin H (SEH) has recently been shown to be present at similar levels as SEA in food poisoning outbreaks. Thus, we set out to investigate the thermo-stability of the three-dimensional structures of SEA, SEH and staphylococcal enterotoxin E (SEE), since heat inactivation is a common method to inactivate toxins during food processing. Interestingly, the investigated toxins behaved distinctly different upon heating. SEA and SEE were more stable at slightly acidic pH values, while SEH adopted an extremely stable structure at neutral pH, with almost no effects on secondary structural elements upon heating to 95°C, and with reversible formation of tertiary structure upon subsequent cooling to room temperature. Taken together, the data suggests that the family of staphylococcal enterotoxins have different ability to withstand heat, and thus the exact profile of heat inactivation for all SEs causing food poisoning needs to be considered to improve food safety.
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Söndergaard Hansen, JesperLund University,Lunds universitet,Medicinsk strukturbiologi,Forskargrupper vid Lunds universitet,Medical Structural Biology,Lund University Research Groups(Swepub:lu)med-js_
(author)
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André, IngemarLund University,Lunds universitet,Biokemi och Strukturbiologi,Centrum för Molekylär Proteinvetenskap,Kemiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Biochemistry and Structural Biology,Center for Molecular Protein Science,Department of Chemistry,Departments at LTH,Faculty of Engineering, LTH(Swepub:lu)fkm2-ian
(author)
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Lindkvist-Petersson, KarinLund University,Lunds universitet,Medicinsk strukturbiologi,Forskargrupper vid Lunds universitet,Medical Structural Biology,Lund University Research Groups(Swepub:lu)mbfy-kpe
(author)
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Medicinsk strukturbiologiForskargrupper vid Lunds universitet
(creator_code:org_t)
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In:PLoS ONE: Public Library of Science (PLoS)12:21932-6203
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