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A review of the bio...
A review of the biology of calcium phosphate sequestration with special reference to milk.
- Article/chapterEnglish2015
Publisher, publication year, extent ...
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2014-07-16
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Springer Science and Business Media LLC,2015
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LIBRIS-ID:oai:lup.lub.lu.se:d85543d8-2529-46e2-8a5f-807965deaf81
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https://lup.lub.lu.se/record/5039072URI
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https://doi.org/10.1007/s13594-014-0177-2DOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:for swepub-publicationtype
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Subject category:ref swepub-contenttype
Notes
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In milk, a stable fluid is formed in which sequestered nanoclusters of calcium phosphate are substructures in casein micelles. As a result, calcium and phosphate concentrations in milk can be far in excess of their solubility. Variations of calcium, phosphate and casein concentrations in milks, both within and among species, are mainly due to the formation of the nanocluster complexes. Caseins evolved from tooth and bone proteins well before the evolution of lactation. It has therefore been suggested that the role of caseins in milk is an adaptation of an antecedent function in the control of some aspect of biomineralisation. There is new evidence that nanocluster-type complexes are also present in blood serum and, by implication, in many other closely related biofluids. Because such fluids are stable but nevertheless supersaturated with respect to the bone and tooth mineral hydroxyapatite, they allow soft and mineralised tissues to co-exist in the same organism with relative ease. An appreciable concentration of nanocluster complexes exists in fresh saliva. Such saliva may stabilise tooth mineral and help to repair demineralised lesions. In the extracellular matrix of bone, nanocluster complexes may be involved in directing the amorphous calcium phosphate to intrafibrillar spaces in collagen where they can mature into oriented apatite crystals. Thus, evidence is accumulating that calcium phosphate sequestration by phosphopeptides to form equilibrium complexes, first observed in milk, is more generally important in the control of physiological calcification.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Nylander, TommyLund University,Lunds universitet,Fysikalisk kemi,Enheten för fysikalisk och teoretisk kemi,Kemiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Physical Chemistry,Physical and theoretical chemistry,Department of Chemistry,Departments at LTH,Faculty of Engineering, LTH(Swepub:lu)fk1-tny
(author)
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Teixeira, Susana C M
(author)
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Holt, Carl
(author)
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Fysikalisk kemiEnheten för fysikalisk och teoretisk kemi
(creator_code:org_t)
Related titles
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In:Dairy Science & Technology: Springer Science and Business Media LLC95:1, s. 3-141958-55861958-5594
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