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A White Paper on Co...
A White Paper on Collagen Hydrolyzates and Ultrahydrolyzates : Potential Supplements to Support Joint Health in Osteoarthritis?
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- Mobasheri, Ali (author)
- University of Liège,University Medical Center Utrecht,First Affiliated Hospital of Sun Yat-sen University
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- Mahmoudian, Armaghan (author)
- Lund University,Lunds universitet,Lund OsteoArthritis Division - Clinical Epidemiology Unit,Forskargrupper vid Lunds universitet,Lund University Research Groups
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- Kalvaityte, Ursule (author)
- State Research Institute Innovative Medicine Center
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- Uzieliene, Ilona (author)
- State Research Institute Innovative Medicine Center
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- Larder, Christina E. (author)
- McGill University
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- Iskandar, Michèle M. (author)
- McGill University
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- Kubow, Stan (author)
- McGill University
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- Hamdan, Paulo Cesar (author)
- Federal University of Rio de Janeiro
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de Almeida, Cyro Scala (author)
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- Favazzo, Lacey J. (author)
- University of Colorado
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- van Loon, Luc J.C. (author)
- Maastricht University
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- Emans, Pieter J. (author)
- Maastricht University
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- Plapler, Pérola G. (author)
- University of São Paulo
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- Zuscik, Michael J. (author)
- University of Colorado
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(creator_code:org_t)
- 2021-10-30
- 2021
- English.
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In: Current Rheumatology Reports. - : Springer Science and Business Media LLC. - 1523-3774 .- 1534-6307. ; 23:11
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Abstract
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- Purpose of Review: Osteoarthritis (OA) is the most common forms of arthritis in the general population, accounting for more pain and functional disability than any other musculoskeletal disease. There are currently no approved disease modifying drugs for OA. In the absence of effective pharmacotherapy, many patients with OA turn to nutritional supplements and nutraceuticals, including collagen derivatives. Collagen hydrolyzates and ultrahydrolyzates are terms used to describe collagens that have been broken down into small peptides and amino acids in the presence of collagenases and high pressure. Recent Findings: This article reviews the relevant literature and serves as a White Paper on collagen hydrolyzates and ultrahydrolyzates as emerging supplements often advertised to support joint health in OA. Collagen hydrolyzates have demonstrated some evidence of efficacy in a handful of small scale clinical trials, but their ability to treat and reverse advanced joint disease remains highly speculative, as is the case for other nutritional supplements. Summary: The aim of this White Paper is to stimulate research and development of collagen-based supplements for patients with OA and other musculoskeletal diseases at academic and industrial levels. This White Paper does not make any treatment recommendations for OA patients in the clinical context, but simply aims to highlight opportunities for scientific innovation and interdisciplinary collaboration, which are crucial for the development of novel products and nutritional interventions based on the best available and published evidence.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
Keyword
- Collagen hydrolyzate
- Collagen ultra-hydrolyzate
- Denatured collagen
- Joint health
- Nutraceutical
- Nutritional supplement
- Osteoarthritis
Publication and Content Type
- for (subject category)
- ref (subject category)
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- By the author/editor
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Mobasheri, Ali
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Mahmoudian, Arma ...
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Kalvaityte, Ursu ...
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Uzieliene, Ilona
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Larder, Christin ...
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Iskandar, Michèl ...
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Kubow, Stan
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Hamdan, Paulo Ce ...
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de Almeida, Cyro ...
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Favazzo, Lacey J ...
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van Loon, Luc J. ...
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Emans, Pieter J.
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Plapler, Pérola ...
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Zuscik, Michael ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Rheumatology and ...
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Current Rheumato ...
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Lund University