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Association of the ...
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Tsuchiya, Takafumi
(author)
Association of the calpain-10 gene with type 2 diabetes in Europeans: Results of pooled and meta-analyses
- Article/chapterEnglish2006
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LIBRIS-ID:oai:lup.lub.lu.se:d9b44a34-dae2-479e-99ba-a6e7735a3914
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https://lup.lub.lu.se/record/392952URI
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https://doi.org/10.1016/j.ymgme.2006.05.013DOI
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Language:English
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Summary in:English
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Subject category:art swepub-publicationtype
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Subject category:ref swepub-contenttype
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We conducted pooled and meta-analyses of the association of the calpain-10 gene (CAPN10) polymorphisms SNP-43, Indel-19 and SNP-63 individually and as haplotypes with type 2 diabetes (T2D) in 3237 patients and 2935 controls of European ancestry. In the pooled analyses, the common SNP-43*G allele was associated with modest but statistically significant increased risk of T2D (odds ratio (OR) = 1.11 (95% confidence interval (0), 1.02-1.20), P = 0.01). Two haplotype combinations were associated with increased risk of T2D) (1-2-1/1-2-1, OR = 1.20 (1.03-1.41), P = 0.02; and 1-1-2/1-2-1, OR = 1.26 (1.01-1.59), P = 0.04) and one with decreased risk (1-1-1/2-2-1, OR = 0.86 (0.75-0.99), P = 0.03). The meta-analysis also showed a significant effect of the 1-2-1/1-2-1 haplogenotype on risk (OR = 1.25 (1.05-1.50), P = 0.01). However, there was evidence for heterogeneity with respect to this effect (P = 0.06). The heterogeneity appeared to be due to data sets in which the cases were selected from samples used in linkage studies of T2D. Using only the population-based case-control samples removed the heterogeneity (P = 0.89) and strengthened the evidence for association with T2D) in both the pooled (SNP-43*G, OR = 1.19 (1.07-1.32), P = 0.001; 1-2-1/1-2-1 haplogenotype, OR = 1.46 (1.19-1.78), P = 0.0003; 1-1-2/1-2-1 haplogenotype, OR = 1.52 (1.12-2.06), P = 0.007; and 1-1-1/2-2-1 haplogenotype, OR = 0.83 (0.70-0.99), P = 0.03) and the meta-analysis (SNP-43*G, OR = 1.18 (1.05-1.32), P = 0.005; 1-2-1/1-2-1 haplogenotype, OR = 1.68 (1.33-2.11), P = 0.00001). The pooled and meta-analyses as well as the linkage disequilibrium and haplotype diversity studies suggest a role for genetic variation in CAPN10 affecting risk of T2D in Europeans. (c) 2006 Elsevier Inc. All rights reserved.
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Schwarz, Peter E. H.
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del Bosque-Plata, Laura
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Hayes, M. Geoffrey
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Dina, Christian
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Froguel, Philippe
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Towers, G. Wayne
(author)
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Fischer, Sabine
(author)
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Temelkova-Kurktschiev, Theodora
(author)
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Rietzsch, Hannes
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Graessler, Juergen
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Vcelak, Josef
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Palyzova, Daniela
(author)
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Selisko, Thomas
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Bendlova, Bela
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Schulze, Jan
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Julius, Ulrich
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Hanefeld, Markolf
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Weedon, Michael N.
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Evans, Julie C.
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Frayling, Timothy M.
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Hattersley, Andrew T.
(author)
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Orho-Melander, MarjuLund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups(Swepub:lu)endo-mor
(author)
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Groop, LeifLund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups(Swepub:lu)endo-lgr
(author)
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Malecki, Maciej T.
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Hansen, Torben
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Pedersen, Oluf
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Fingerlin, Tasha E.
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Boehnke, Michael
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Hanis, Craig L.
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Cox, Nancy J.
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Bell, Graeme I.
(author)
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Genomik, diabetes och endokrinologiForskargrupper vid Lunds universitet
(creator_code:org_t)
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In:Molecular Genetics and Metabolism: Elsevier BV89:1-2, s. 174-1841096-7192
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Tsuchiya, Takafu ...
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Schwarz, Peter E ...
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del Bosque-Plata ...
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Hayes, M. Geoffr ...
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Dina, Christian
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Froguel, Philipp ...
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Towers, G. Wayne
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Fischer, Sabine
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Temelkova-Kurkts ...
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Rietzsch, Hannes
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Graessler, Juerg ...
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Vcelak, Josef
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Palyzova, Daniel ...
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Selisko, Thomas
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Bendlova, Bela
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Schulze, Jan
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Julius, Ulrich
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Hanefeld, Markol ...
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Weedon, Michael ...
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Evans, Julie C.
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Frayling, Timoth ...
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Hattersley, Andr ...
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Orho-Melander, M ...
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Groop, Leif
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Malecki, Maciej ...
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Hansen, Torben
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Pedersen, Oluf
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Fingerlin, Tasha ...
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Boehnke, Michael
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Hanis, Craig L.
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Cox, Nancy J.
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Bell, Graeme I.
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Molecular Geneti ...
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