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A multi-omic study ...
A multi-omic study reveals BTG2 as a reliable prognostic marker for early-stage non-small cell lung cancer
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- Shen, Sipeng (author)
- Nanjing Medical University,Harvard University
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- Zhang, Ruyang (author)
- Nanjing Medical University
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- Guo, Yichen (author)
- Harvard University
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- Loehrer, Elizabeth (author)
- Harvard University
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- Wei, Yongyue (author)
- Nanjing Medical University
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- Zhu, Ying (author)
- Nanjing Medical University
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- Yuan, Qianyu (author)
- Harvard University
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- Moran, Sebastian (author)
- University of Barcelona
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- Fleischer, Thomas (author)
- Oslo university hospital
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- Bjaanæs, Maria M. (author)
- Oslo university hospital
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- Karlsson, Anna (author)
- Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Planck, Maria (author)
- Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Staaf, Johan (author)
- Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Helland, Åslaug (author)
- University of Oslo,Oslo university hospital
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- Esteller, Manel (author)
- University of Barcelona
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- Su, Li (author)
- Nanjing Medical University,Harvard University
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- Chen, Feng (author)
- Nanjing Medical University
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- Christiani, David C. (author)
- Harvard Medical School,Harvard University,Nanjing Medical University
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(creator_code:org_t)
- 2018-05-04
- 2018
- English.
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In: Molecular Oncology. - : Wiley. - 1574-7891 .- 1878-0261. ; 12:6, s. 913-924
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Abstract
Subject headings
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- B-cell translocation gene 2 (BTG2) is a tumour suppressor protein known to be downregulated in several types of cancer. In this study, we investigated a potential role for BTG2 in early-stage non-small cell lung cancer (NSCLC) survival. We analysed BTG2 methylation data from 1230 early-stage NSCLC patients from five international cohorts, as well as gene expression data from 3038 lung cancer cases from multiple cohorts. Three CpG probes (cg01798157, cg06373167, cg23371584) that detected BTG2 hypermethylation in tumour tissues were associated with lower overall survival. The prognostic model based on methylation could distinguish patient survival in the four cohorts [hazard ratio (HR) range, 1.51-2.21] and the independent validation set (HR = 1.85). In the expression analysis, BTG2 expression was positively correlated with survival in each cohort (HR range, 0.28-0.68), which we confirmed with meta-analysis (HR = 0.61, 95% CI 0.54-0.68). The three CpG probes were all negatively correlated with BTG2 expression. Importantly, an integrative model of BTG2 methylation, expression and clinical information showed better predictive ability in the training set and validation set. In conclusion, the methylation and integrated prognostic signatures based on BTG2 are stable and reliable biomarkers for early-stage NSCLC. They may have new applications for appropriate clinical adjuvant trials and personalized treatments in the future.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- BTG2
- Early-stage non-small cell lung cancer
- Multi-omic
- Prognosis
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Shen, Sipeng
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Zhang, Ruyang
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Guo, Yichen
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Loehrer, Elizabe ...
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Wei, Yongyue
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Zhu, Ying
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Yuan, Qianyu
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Moran, Sebastian
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Fleischer, Thoma ...
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Bjaanæs, Maria M ...
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Karlsson, Anna
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Planck, Maria
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Staaf, Johan
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Helland, Åslaug
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Esteller, Manel
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Su, Li
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Chen, Feng
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Christiani, Davi ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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Molecular Oncolo ...
- By the university
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Lund University