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The E3 ligase synov...
The E3 ligase synoviolin controls body weight and mitochondrial biogenesis through negative regulation of PGC-1 beta
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Fujita, Hidetoshi (author)
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Yagishita, Naoko (author)
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Aratani, Satoko (author)
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Saito-Fujita, Tomoko (author)
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Morota, Saori (author)
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Yamano, Yoshihisa (author)
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- Hansson, Magnus (author)
- Lund University,Lunds universitet,Klinisk neurofysiologi,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Mitokondriell Medicin,Forskargrupper vid Lunds universitet,Clinical Neurophysiology,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Mitochondrial Medicine,Lund University Research Groups,Klinisk fysiologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Clinical Physiology (Lund),Section V,Department of Clinical Sciences, Lund
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Inazu, Masato (author)
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Kokuba, Hiroko (author)
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Sudo, Katsuko (author)
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Sato, Eiichi (author)
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Kawahara, Ko-ichi (author)
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Nakajima, Fukami (author)
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Hasegawa, Daisuke (author)
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Higuchi, Itsuro (author)
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Sato, Tomoo (author)
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Araya, Natsumi (author)
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Usui, Chie (author)
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Nishioka, Kenya (author)
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Nakatani, Yu (author)
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Maruyama, Ikuro (author)
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Usui, Masahiko (author)
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Hara, Naomi (author)
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Uchino, Hiroyuki (author)
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- Elmer, Eskil (author)
- Lund University,Lunds universitet,Klinisk neurofysiologi,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Mitokondriell Medicin,Forskargrupper vid Lunds universitet,Clinical Neurophysiology,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Mitochondrial Medicine,Lund University Research Groups
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Nishioka, Kusuki (author)
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Nakajima, Toshihiro (author)
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(creator_code:org_t)
- EMBO, 2015
- 2015
- English.
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In: EMBO Journal. - : EMBO. - 1460-2075 .- 0261-4189. ; 34:8, s. 1042-1055
- Related links:
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http://www.ncbi.nlm....
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http://dx.doi.org/10...
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https://europepmc.or...
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https://lup.lub.lu.s...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Subject headings
Close
- Obesity is a major global public health problem, and understanding its pathogenesis is critical for identifying a cure. In this study, a gene knockout strategy was used in post-neonatal mice to delete synoviolin (Syvn) 1/Hrd1/Der3, an ER-resident E3 ubiquitin ligase with known roles in homeostasis maintenance. Syvn1 deficiency resulted in weight loss and lower accumulation of white adipose tissue in otherwise wild-type animals as well as in genetically obese (ob/ob and db/db) and adipose tissue-specific knockout mice as compared to control animals. SYVN1 interacted with and ubiquitinated the thermogenic coactivator peroxisome proliferator-activated receptor coactivator (PGC)-1 beta, and Syvn1 mutants showed upregulation of PGC-1 beta target genes and increase in mitochondrion number, respiration, and basal energy expenditure in adipose tissue relative to control animals. Moreover, the selective SYVN1 inhibitor LS-102 abolished the negative regulation of PGC-1 beta by SYVN1 and prevented weight gain in mice. Thus, SYVN1 is a novel post-translational regulator of PGC-1 beta and a potential therapeutic target in obesity treatment.
Subject headings
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
Keyword
- endoplasmic reticulum
- mitochondria
- obesity
- PGC-1 beta
- synoviolin
Publication and Content Type
- art (subject category)
- ref (subject category)
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To the university's database
- By the author/editor
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Fujita, Hidetosh ...
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Yagishita, Naoko
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Aratani, Satoko
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Saito-Fujita, To ...
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Morota, Saori
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Yamano, Yoshihis ...
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show more...
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Hansson, Magnus
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Inazu, Masato
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Kokuba, Hiroko
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Sudo, Katsuko
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Sato, Eiichi
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Kawahara, Ko-ich ...
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Nakajima, Fukami
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Hasegawa, Daisuk ...
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Higuchi, Itsuro
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Sato, Tomoo
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Araya, Natsumi
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Usui, Chie
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Nishioka, Kenya
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Nakatani, Yu
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Maruyama, Ikuro
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Usui, Masahiko
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Hara, Naomi
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Uchino, Hiroyuki
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Elmer, Eskil
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Nishioka, Kusuki
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Nakajima, Toshih ...
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show less...
- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Biochemistry and ...
- Articles in the publication
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EMBO Journal
- By the university
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Lund University