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The association bet...
The association between plasma miR-122-5p release pattern at admission and all-cause mortality or shock after out-of-hospital cardiac arrest
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- Gilje, Patrik (author)
- Lund University,Lunds universitet,Molekylär kardiologi,Forskargrupper vid Lunds universitet,Molecular Cardiology,Lund University Research Groups
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- Frydland, Martin (author)
- Copenhagen University Hospital
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- Bro-Jeppesen, John (author)
- Copenhagen University Hospital
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- Dankiewicz, Josef (author)
- Lund University,Lunds universitet,Centrum för hjärtstopp,Forskargrupper vid Lunds universitet,Center for cardiac arrest,Lund University Research Groups
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- Friberg, Hans (author)
- Lund University,Lunds universitet,Centrum för hjärtstopp,Forskargrupper vid Lunds universitet,Center for cardiac arrest,Lund University Research Groups
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- Rundgren, Malin (author)
- Lund University,Lunds universitet,Centrum för hjärtstopp,Forskargrupper vid Lunds universitet,Center for cardiac arrest,Lund University Research Groups
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- Devaux, Yvan (author)
- Luxembourg Institute of Health
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Stammet, Pascal (author)
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- Al-Mashat, Mariam (author)
- Lund University,Lunds universitet,Hjärt-MR-gruppen i Lund,Forskargrupper vid Lunds universitet,Lund Cardiac MR Group,Lund University Research Groups
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- Jögi, Jonas (author)
- Lund University,Lunds universitet,Hjärt-MR-gruppen i Lund,Forskargrupper vid Lunds universitet,Lund Cardiac MR Group,Lund University Research Groups
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- Kjaergaard, Jesper (author)
- Copenhagen University Hospital
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- Hassager, Christian (author)
- Copenhagen University Hospital
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- Erlinge, David (author)
- Lund University,Lunds universitet,Molekylär kardiologi,Forskargrupper vid Lunds universitet,Molecular Cardiology,Lund University Research Groups
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(creator_code:org_t)
- 2019
- 2019
- English.
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In: Biomarkers. - 1354-750X. ; 24:1, s. 29-35
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Abstract
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- Background: Data suggests that the plasma levels of the liver-specific miR-122-5p might both be a marker of cardiogenic shock and a prognostic marker of out-of-hospital cardiac arrest (OHCA). Our aim was to characterize plasma miR-122-5p at admission after OHCA and to assess the association between miR-122-5p and relevant clinical factors such all-cause mortality and shock at admission after OHCA. Methods: In the pilot trial, 10 survivors after OHCA were compared to 10 age- and sex-matched controls. In the main trial, 167 unconscious survivors of OHCA from the Targeted Temperature Management (TTM) trial were included. Results: In the pilot trial, plasma miR-122-5p at admission after OHCA was 400-fold elevated compared to controls. In the main trial, plasma miR-122-5p at admission was independently associated with lactate and bystander cardiopulmonary resuscitation. miR-122-5p at admission was not associated with shock at admission (p = 0.14) or all-cause mortality (p = 0.35). Target temperature (33 °C vs 36 °C) was not associated with miR-122-5p levels at any time point. Conclusions: After OHCA, miR-122-5p demonstrated a marked acute increase in plasma and was independently associated with lactate and bystander resuscitation. However, miR-122-5p at admission was not associated with all-cause mortality or shock at admission.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Keyword
- bystander CPR
- cardiac arrest
- lactate
- outcome
- Plasma microRNA
- shock
Publication and Content Type
- art (subject category)
- ref (subject category)
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Biomarkers
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- By the author/editor
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Gilje, Patrik
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Frydland, Martin
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Bro-Jeppesen, Jo ...
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Dankiewicz, Jose ...
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Friberg, Hans
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Rundgren, Malin
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show more...
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Devaux, Yvan
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Stammet, Pascal
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Al-Mashat, Maria ...
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Jögi, Jonas
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Kjaergaard, Jesp ...
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Hassager, Christ ...
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Erlinge, David
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
- Articles in the publication
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Biomarkers
- By the university
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Lund University