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  • Gilje, PatrikLund University,Lunds universitet,Molekylär kardiologi,Forskargrupper vid Lunds universitet,Molecular Cardiology,Lund University Research Groups (author)

The association between plasma miR-122-5p release pattern at admission and all-cause mortality or shock after out-of-hospital cardiac arrest

  • Article/chapterEnglish2019

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  • 2019

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  • LIBRIS-ID:oai:lup.lub.lu.se:db7ac51f-2279-4afc-98d6-95ef838e2fe9
  • https://lup.lub.lu.se/record/db7ac51f-2279-4afc-98d6-95ef838e2fe9URI
  • https://doi.org/10.1080/1354750X.2018.1499804DOI

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  • Language:English
  • Summary in:English

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  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

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  • Background: Data suggests that the plasma levels of the liver-specific miR-122-5p might both be a marker of cardiogenic shock and a prognostic marker of out-of-hospital cardiac arrest (OHCA). Our aim was to characterize plasma miR-122-5p at admission after OHCA and to assess the association between miR-122-5p and relevant clinical factors such all-cause mortality and shock at admission after OHCA. Methods: In the pilot trial, 10 survivors after OHCA were compared to 10 age- and sex-matched controls. In the main trial, 167 unconscious survivors of OHCA from the Targeted Temperature Management (TTM) trial were included. Results: In the pilot trial, plasma miR-122-5p at admission after OHCA was 400-fold elevated compared to controls. In the main trial, plasma miR-122-5p at admission was independently associated with lactate and bystander cardiopulmonary resuscitation. miR-122-5p at admission was not associated with shock at admission (p = 0.14) or all-cause mortality (p = 0.35). Target temperature (33 °C vs 36 °C) was not associated with miR-122-5p levels at any time point. Conclusions: After OHCA, miR-122-5p demonstrated a marked acute increase in plasma and was independently associated with lactate and bystander resuscitation. However, miR-122-5p at admission was not associated with all-cause mortality or shock at admission.

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  • Frydland, MartinCopenhagen University Hospital (author)
  • Bro-Jeppesen, JohnCopenhagen University Hospital (author)
  • Dankiewicz, JosefLund University,Lunds universitet,Centrum för hjärtstopp,Forskargrupper vid Lunds universitet,Center for cardiac arrest,Lund University Research Groups(Swepub:lu)med-jfd (author)
  • Friberg, HansLund University,Lunds universitet,Centrum för hjärtstopp,Forskargrupper vid Lunds universitet,Center for cardiac arrest,Lund University Research Groups(Swepub:lu)efor-hfr (author)
  • Rundgren, MalinLund University,Lunds universitet,Centrum för hjärtstopp,Forskargrupper vid Lunds universitet,Center for cardiac arrest,Lund University Research Groups(Swepub:lu)med-mrg (author)
  • Devaux, YvanLuxembourg Institute of Health (author)
  • Stammet, Pascal (author)
  • Al-Mashat, MariamLund University,Lunds universitet,Hjärt-MR-gruppen i Lund,Forskargrupper vid Lunds universitet,Lund Cardiac MR Group,Lund University Research Groups(Swepub:lu)med-ma- (author)
  • Jögi, JonasLund University,Lunds universitet,Hjärt-MR-gruppen i Lund,Forskargrupper vid Lunds universitet,Lund Cardiac MR Group,Lund University Research Groups(Swepub:lu)klin-jjo (author)
  • Kjaergaard, JesperCopenhagen University Hospital (author)
  • Hassager, ChristianCopenhagen University Hospital (author)
  • Erlinge, DavidLund University,Lunds universitet,Molekylär kardiologi,Forskargrupper vid Lunds universitet,Molecular Cardiology,Lund University Research Groups(Swepub:lu)kard-der (author)
  • Molekylär kardiologiForskargrupper vid Lunds universitet (creator_code:org_t)

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  • In:Biomarkers24:1, s. 29-351354-750X

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