onr:"swepub:oai:lup.lub.lu.se:dbfc380a-7a2b-47d6-a377-ab72d48faee3"
Search: onr:"swepub:oai:lup.lub.lu.se:dbfc380a-7a2b-47d6-a377-ab72d48faee3" > Perfluoroalkyl subs...
- 1 of 1
- Previous record
- Next record
- To hitlist
Perfluoroalkyl substances and time to pregnancy in couples from Greenland, Poland and Ukraine
-
- Jørgensen, Kristian T. (author)
- Bispebjerg Hospital
-
- Specht, Ina O. (author)
- Bispebjerg Hospital
-
- Lenters, Virissa (author)
- Utrecht University
- show more...
- show less...
- (creator_code:org_t)
- 2014
- 2014
- English.
- In: Environmental Health: A Global Access Science Source. - 1476-069X. ; 13:1
- Journal article (peer-reviewed)
Abstract
Subject headings
Close
- Background: Perfluoroalkyl substances (PFAS) are suggested to affect human fecundity through longer time to pregnancy (TTP). We studied the relationship between four abundant PFAS and TTP in pregnant women from Greenland, Poland and Ukraine representing varying PFAS exposures and pregnancy planning behaviors. Methods: We measured serum levels of perfluorooctanoic acid (PFOA), perfluorooctane sulfonate (PFOS), perfluorohexane sulfonic acid (PFHxS) and perfluorononanoic acid (PFNA) in 938 women from Greenland (448 women), Poland (203 women) and Ukraine (287 women). PFAS exposure was assessed on a continuous logarithm transformed scale and in country-specific tertiles. We used Cox discrete-time models and logistic regression to estimate fecundability ratios (FRs) and infertility (TTP >13 months) odds ratios (ORs), respectively, and 95% confidence intervals (CI) according to PFAS levels. Adjusted analyses of the association between PFAS and TTP were done for each study population and in a pooled sample. Results: Higher PFNA levels were associated with longer TTP in the pooled sample (log-scale FR∈=∈0.80; 95% CI 0.69-0.94) and specifically in women from Greenland (log-scale FR∈=∈0.72; 95% CI 0.58-0.89). ORs for infertility were also increased in the pooled sample (log-scale OR∈=∈1.53; 95% CI 1.08-2.15) and in women from Greenland (log-scale OR∈=∈1.97; 95% CI 1.22-3.19). However, in a sensitivity analysis of primiparous women these associations could not be replicated. Associations with PFNA were weaker for women from Poland and Ukraine. PFOS, PFOA and PFHxS were not consistently associated with TTP. Conclusions: Findings do not provide consistent evidence that environmental exposure to PFAS is impairing female fecundity by delaying time taken to conceive.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)
Keyword
- Fecundity
- Infertility
- Perfluorinated compounds
- Persistent environmental pollutants
Publication and Content Type
- art (subject category)
- ref (subject category)
Find in a library
- Environmental Health: A Global Access Science Source (Search for host publication in LIBRIS)
To the university's database
- 1 of 1
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Jørgensen, Krist ...
- Specht, Ina O.
- Lenters, Virissa
- Bach, Cathrine C ...
- Rylander, Lars
- Jönsson, Bo A.G.
- show more...
- Lindh, Christian ...
- Giwercman, Aleks ...
- Heederik, Dick
- Toft, Gunnar
- Bonde, Jens Pete ...
- show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Clinical Medicin ...
- and Obstetrics Gynae ...
- Articles in the publication
- Environmental He ...
- By the university
- Lund University
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
