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High rate of recurr...
High rate of recurrent venous thromboembolism in patients with myeloproliferative neoplasms and effect of prophylaxis with Vitamin K antagonists
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- De Stefano, V. (author)
- Catholic University of the Sacred Heart, Rome
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- Ruggeri, M. (author)
- Ospedale San Bortolo
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- Cervantes, F. (author)
- Institutd' Investigacions Biomèdiques August Pi iSunyer (IDIBAPS)
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- Alvarez-Larran, A. (author)
- Hospital del Mar Medical Research Institute
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- Iurlo, A. (author)
- Maggiore Hospital Policlinico
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- Randi, M. L. (author)
- University Hospital of Padua
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- Elli, E. (author)
- San Gerardo Hospital
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- Finazzi, M. C. (author)
- Papa Giovanni XXIII Hospital
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- Finazzi, G. (author)
- Papa Giovanni XXIII Hospital
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- Zetterberg, E. (author)
- Lund University,Lunds universitet,Klinisk koagulationsmedicin, Malmö,Forskargrupper vid Lunds universitet,Clinical Coagulation, Malmö,Lund University Research Groups,Skåne University Hospital
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- Vianelli, N. (author)
- University of Bologna
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- Gaidano, G. (author)
- University of Eastern Piedmont
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- Rossi, E. (author)
- Catholic University of the Sacred Heart, Rome
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- Betti, S. (author)
- Catholic University of the Sacred Heart, Rome
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- Nichele, I. (author)
- Ospedale San Bortolo
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- Cattaneo, D. (author)
- Maggiore Hospital Policlinico
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- Palova, M. (author)
- University Hospital of Olomouc
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- Ellis, M. H. (author)
- Meir Medical Center
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- Cacciola, R. (author)
- University Hospital of Padua
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- Tieghi, A. (author)
- Arcispedale Santa Maria Nuova
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- Hernandez-Boluda, J. C. (author)
- University and Polytechnic Hospital la Fe
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- Pungolino, E. (author)
- Niguarda Hospital
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- Specchia, G. (author)
- Bari University Hospital
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- Rapezzi, D. (author)
- A.O. Santa Croce e Carle
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- Forcina, A. (author)
- San Raffaele Scientific Institute
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- Musolino, C. (author)
- Azienda Ospedaliera Universitaria Policlinico "G. Martino"
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- Carobbio, A. (author)
- Papa Giovanni XXIII Hospital
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- Griesshammer, M. (author)
- Johannes Wesling Klinikum Minden
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- Sant'Antonio, E. (author)
- Papa Giovanni XXIII Hospital
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- Vannucchi, A. M. (author)
- Papa Giovanni XXIII Hospital
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- Barbui, T. (author)
- Papa Giovanni XXIII Hospital
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(creator_code:org_t)
- 2016-04-26
- 2016
- English 7 s.
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In: Leukemia. - : Springer Science and Business Media LLC. - 0887-6924 .- 1476-5551. ; 30:10, s. 2032-2038
- Related links:
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http://dx.doi.org/10...
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Abstract
Subject headings
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- The optimal duration of treatment with vitamin K antagonists (VKA) after venous thromboembolism (VTE) in patients with Philadelphia-negative myeloproliferative neoplasms (MPNs) is uncertain. To tackle this issue, we retrospectively studied 206 patients with MPN-related VTE (deep venous thrombosis of the legs and/or pulmonary embolism). After this index event, we recorded over 695 pt-years 45 recurrences, venous in 36 cases, with an incidence rate (IR) of 6.5 per 100 pt-years (95% confidence interval (CI): 4.9-8.6). One hundred fifty-five patients received VKA; the IR of recurrent thrombosis per 100 pt-years was 4.7 (95% CI: 2.8-7.3) on VKA and 8.9 (95% CI: 5.7-13.2) off VKA (P=0.03). In patients receiving VKA, the IR of recurrent thrombosis per 100 pt-years was 5.3 (95% CI: 3.2-8.4) among 108 patients on long-term VKA and 12.8 (95% CI: 7.3-20.7) after discontinuation among the 47 who ceased treatment (P=0.008), with a doubled risk of recurrence after stopping VKA (hazard ratio: 2.21, 95% CI: 1.19-5.30). The IR of major bleeding per 100 pt-years was 2.4 (95%: CI: 1.1-4.5) on VKA and 0.7 (95% CI: 0.08-2.5) off VKA (P=0.08). In conclusion, in MPN patients with VTE recurrent thrombosis is significantly reduced by VKA and caution should be adopted in discontinuation; however, the incidence of recurrence on treatment remains high, calling for clinical trials aimed to improve prophylaxis in this setting.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
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Leukemia
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To the university's database
- By the author/editor
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De Stefano, V.
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Ruggeri, M.
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Cervantes, F.
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Alvarez-Larran, ...
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Iurlo, A.
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Randi, M. L.
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show more...
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Elli, E.
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Finazzi, M. C.
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Finazzi, G.
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Zetterberg, E.
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Vianelli, N.
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Gaidano, G.
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Rossi, E.
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Betti, S.
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Nichele, I.
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Cattaneo, D.
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Palova, M.
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Ellis, M. H.
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Cacciola, R.
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Tieghi, A.
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Hernandez-Boluda ...
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Pungolino, E.
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Specchia, G.
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Rapezzi, D.
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Forcina, A.
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Musolino, C.
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Carobbio, A.
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Griesshammer, M.
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Sant'Antonio, E.
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Vannucchi, A. M.
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Barbui, T.
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Hematology
- Articles in the publication
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Leukemia
- By the university
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Lund University