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  • De Stefano, V.Catholic University of the Sacred Heart, Rome (author)

High rate of recurrent venous thromboembolism in patients with myeloproliferative neoplasms and effect of prophylaxis with Vitamin K antagonists

  • Article/chapterEnglish2016

Publisher, publication year, extent ...

  • 2016-04-26
  • Springer Science and Business Media LLC,2016
  • 7 s.

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:dcc01f4e-f69d-4160-b647-428b2ceaa8df
  • https://lup.lub.lu.se/record/dcc01f4e-f69d-4160-b647-428b2ceaa8dfURI
  • https://doi.org/10.1038/leu.2016.85DOI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • The optimal duration of treatment with vitamin K antagonists (VKA) after venous thromboembolism (VTE) in patients with Philadelphia-negative myeloproliferative neoplasms (MPNs) is uncertain. To tackle this issue, we retrospectively studied 206 patients with MPN-related VTE (deep venous thrombosis of the legs and/or pulmonary embolism). After this index event, we recorded over 695 pt-years 45 recurrences, venous in 36 cases, with an incidence rate (IR) of 6.5 per 100 pt-years (95% confidence interval (CI): 4.9-8.6). One hundred fifty-five patients received VKA; the IR of recurrent thrombosis per 100 pt-years was 4.7 (95% CI: 2.8-7.3) on VKA and 8.9 (95% CI: 5.7-13.2) off VKA (P=0.03). In patients receiving VKA, the IR of recurrent thrombosis per 100 pt-years was 5.3 (95% CI: 3.2-8.4) among 108 patients on long-term VKA and 12.8 (95% CI: 7.3-20.7) after discontinuation among the 47 who ceased treatment (P=0.008), with a doubled risk of recurrence after stopping VKA (hazard ratio: 2.21, 95% CI: 1.19-5.30). The IR of major bleeding per 100 pt-years was 2.4 (95%: CI: 1.1-4.5) on VKA and 0.7 (95% CI: 0.08-2.5) off VKA (P=0.08). In conclusion, in MPN patients with VTE recurrent thrombosis is significantly reduced by VKA and caution should be adopted in discontinuation; however, the incidence of recurrence on treatment remains high, calling for clinical trials aimed to improve prophylaxis in this setting.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Ruggeri, M.Ospedale San Bortolo (author)
  • Cervantes, F.Institutd' Investigacions Biomèdiques August Pi iSunyer (IDIBAPS) (author)
  • Alvarez-Larran, A.Hospital del Mar Medical Research Institute (author)
  • Iurlo, A.Maggiore Hospital Policlinico (author)
  • Randi, M. L.University Hospital of Padua (author)
  • Elli, E.San Gerardo Hospital (author)
  • Finazzi, M. C.Papa Giovanni XXIII Hospital (author)
  • Finazzi, G.Papa Giovanni XXIII Hospital (author)
  • Zetterberg, E.Lund University,Lunds universitet,Klinisk koagulationsmedicin, Malmö,Forskargrupper vid Lunds universitet,Clinical Coagulation, Malmö,Lund University Research Groups,Skåne University Hospital(Swepub:lu)med-ezt (author)
  • Vianelli, N.University of Bologna (author)
  • Gaidano, G.University of Eastern Piedmont (author)
  • Rossi, E.Catholic University of the Sacred Heart, Rome (author)
  • Betti, S.Catholic University of the Sacred Heart, Rome (author)
  • Nichele, I.Ospedale San Bortolo (author)
  • Cattaneo, D.Maggiore Hospital Policlinico (author)
  • Palova, M.University Hospital of Olomouc (author)
  • Ellis, M. H.Meir Medical Center (author)
  • Cacciola, R.University Hospital of Padua (author)
  • Tieghi, A.Arcispedale Santa Maria Nuova (author)
  • Hernandez-Boluda, J. C.University and Polytechnic Hospital la Fe (author)
  • Pungolino, E.Niguarda Hospital (author)
  • Specchia, G.Bari University Hospital (author)
  • Rapezzi, D.A.O. Santa Croce e Carle (author)
  • Forcina, A.San Raffaele Scientific Institute (author)
  • Musolino, C.Azienda Ospedaliera Universitaria Policlinico "G. Martino" (author)
  • Carobbio, A.Papa Giovanni XXIII Hospital (author)
  • Griesshammer, M.Johannes Wesling Klinikum Minden (author)
  • Sant'Antonio, E.Papa Giovanni XXIII Hospital (author)
  • Vannucchi, A. M.Papa Giovanni XXIII Hospital (author)
  • Barbui, T.Papa Giovanni XXIII Hospital (author)
  • Catholic University of the Sacred Heart, RomeOspedale San Bortolo (creator_code:org_t)

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  • In:Leukemia: Springer Science and Business Media LLC30:10, s. 2032-20380887-69241476-5551

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