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Summary report of t...
Summary report of the TD-3 workshop: characterization of 83 antibodies against prostate-specific antigen
- Article/chapterEnglish1999
Publisher, publication year, extent ...
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Springer Science and Business Media LLC,1999
Numbers
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LIBRIS-ID:oai:lup.lub.lu.se:dd52b522-f26f-4f81-a0d7-cf93c0ba2804
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https://lup.lub.lu.se/record/1115131URI
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https://doi.org/10.1159/000056523DOI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:art swepub-publicationtype
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Subject category:ref swepub-contenttype
Notes
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Twelve research groups participated in the ISOBM TD-3 Workshop in which the reactivity and specificity of 83 antibodies against prostate-specific antigen (PSA) were investigated. Using a variety of techniques including cross-inhibition assays, Western blotting, BIAcore, immunoradiometric assays and immunohistochemistry, the antibodies were categorized into six major groups which formed the basis for mapping onto two- and three-dimensional (2-D and 3-D) models of PSA. The overall findings of the TD-3 Workshop are summarized in this report. In agreement with all participating groups, three main antigenic domains were identified: free PSA-specific epitopes located in or close to amino acids 86-91; discontinuous epitopes specific for PSA without human kallikrein (hK2) cross-reactivity located at or close to amino acids 158-163; and continuous or linear epitopes shared between PSA and hK2 located close to amino acids 3-11. In addition, several minor and partly overlapping domains were also identified. Clearly, the characterization of antibodies from this workshop and the location of their epitopes on the 3-D model of PSA illustrate the importance of selecting appropriate antibody pairs for use in immunoassays. It is hoped that these findings and the epitope nomenclature described in this TD-3 Workshop are used as a standard for future evaluation of anti-PSA antibodies.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Paus, E
(author)
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Allard, W J
(author)
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Andersson, I
(author)
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Andres, C
(author)
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Barnett, T R
(author)
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Becker, CharlotteLund University,Lunds universitet,Klinisk kemi, Malmö,Forskargrupper vid Lunds universitet,Clinical Chemistry, Malmö,Lund University Research Groups(Swepub:lu)klke-cbe
(author)
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Belenky, A
(author)
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Bellanger, L
(author)
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Pellegrino, C M
(author)
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Bormer, O P
(author)
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Davis, G
(author)
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Dowell, B
(author)
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Grauer, L S
(author)
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Jette, D C
(author)
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Karlsson, B
(author)
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Kreutz, F T
(author)
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van der Kwast, T M
(author)
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Lauren, L
(author)
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Leinimaa, M
(author)
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Leinonen, J
(author)
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Lilja, HansLund University,Lunds universitet,Klinisk kemi, Malmö,Forskargrupper vid Lunds universitet,Clinical Chemistry, Malmö,Lund University Research Groups(Swepub:lu)klke-hli
(author)
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Linton, H J
(author)
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Nap, M
(author)
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Nilsson, O
(author)
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Ng, P C
(author)
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Nustad, K
(author)
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Peter, A
(author)
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Pettersson, K
(author)
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Piironen, T
(author)
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Rapp, J
(author)
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Rittenhouse, H G
(author)
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Rye, P D
(author)
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Seguin, P
(author)
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Slota, J
(author)
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Sokoloff, R L
(author)
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Suresh, M R
(author)
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Very, D L
(author)
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Wang, T J
(author)
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Wigheden, IngridLund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups(Swepub:lu)klke-iwi
(author)
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Wolfert, R L
(author)
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Yeung, K K
(author)
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Zhang, W-M
(author)
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Zhou, Z
(author)
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Hilgers, J
(author)
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Klinisk kemi, MalmöForskargrupper vid Lunds universitet
(creator_code:org_t)
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In:Tumor Biology: Springer Science and Business Media LLC20:Suppl. 1, s. 1-121423-03801010-4283
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Stenman, U H
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Paus, E
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Allard, W J
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Andersson, I
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Andres, C
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Barnett, T R
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Becker, Charlott ...
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Belenky, A
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Bellanger, L
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Pellegrino, C M
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Bormer, O P
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Davis, G
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Dowell, B
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Grauer, L S
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Jette, D C
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Karlsson, B
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Kreutz, F T
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van der Kwast, T ...
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Lauren, L
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Leinimaa, M
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Leinonen, J
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Lilja, Hans
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Linton, H J
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Nap, M
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Nilsson, O
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Ng, P C
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Nustad, K
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Peter, A
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Pettersson, K
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Piironen, T
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Rapp, J
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Rittenhouse, H G
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Rye, P D
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Seguin, P
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Slota, J
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Sokoloff, R L
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Suresh, M R
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Very, D L
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Wang, T J
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Wigheden, Ingrid
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Wolfert, R L
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Yeung, K K
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Zhang, W-M
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Zhou, Z
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Hilgers, J
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Tumor Biology
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Lund University