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Human SGBS Cells - ...
Human SGBS Cells - a Unique Tool for Studies of Human Fat Cell Biology
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Fischer-Posovszky, Pamela (author)
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Newell, Felicity S. (author)
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Wabitsch, Martin (author)
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- Tornqvist, Hans (author)
- Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups
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(creator_code:org_t)
- S. Karger AG, 2008
- 2008
- English.
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In: Obesity Facts. - : S. Karger AG. - 1662-4033 .- 1662-4025. ; 1:4, s. 184-189
- Related links:
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http://dx.doi.org/10...
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https://www.karger.c...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Subject headings
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- The human Simpson-Golabi-Behmel syndrome (SGBS) preadipocyte cell strain provides a unique and useful tool for studies of human adipocyte biology. The cells originate from an adipose tissue specimen of a patient with SGBS. They are neither transformed nor immortalized, and provide an almost unlimited source due to their ability to proliferate for up to 50 generations with retained capacity for adipogenic differentiation. So far, the cells have been used for a number of studies on adipose differentiation, adipocyte glucose uptake, lipolysis, apoptosis, regulation of expression of adipokines, and protein translocation. The cells are efficiently differentiated in the presence of PPAR gamma agonists and in the absence of serum and albumin. SGBS adipocytes respond to insulin stimulation by increasing glucose uptake several-fold (EC50 approximately 100 pmol/l), and by very effectively inhibiting (IC50 approximately 10 pmol/l) catecholamine-stimulated lipolysis.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
Keyword
- Adipocyte
- Fat cell
- SGBS
Publication and Content Type
- for (subject category)
- ref (subject category)
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